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Relationship between metamorphopsia and foveal microstructure in patients with branch retinal vein occlusion and cystoid macular edema

  • Retinal Disorders
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Abstract

Purpose

We aimed to investigate the relationship between the severity of metamorphopsia and the foveal microstructure measured with spectral-domain optical coherence tomography (SD-OCT) in patients with cystoid macular edema caused by branch retinal vein occlusion (BRVO-CME).

Methods

The study included 30 eyes of 30 patients with BRVO-CME. We examined visual acuity and the severity of metamorphopsia using M-CHARTS. Central foveal thickness, central retinal thickness at the fovea (CRT-1 mm), and macular volume were measured with SD-OCT software. The status of ellipsoid zone (EZ), external limiting membrane (ELM), outer retinal cyst, and inner retinal cyst was also evaluated.

Results

The mean metamorphopsia score was 0.77 ± 0.50, with 28 of 30 patients (93 %) having metamorphopsia (metamorphopsia score ≥ 0.2). The vertical metamorphopsia score (0.89 ± 0.54) was significantly higher than the horizontal metamorphopsia score (0.64 ± 0.53) (p < 0.005). The status of EZ and ELM was significantly associated with visual acuity, but not with the mean metamorphopsia score. The mean metamorphopsia score was significantly related to CRT-1 mm (p < 0.05) and the presence of inner retinal cyst (p < 0.05).

Conclusions

The severity of metamorphopsia was significantly associated with central retinal thickness and the presence of inner retinal cyst.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan

    Tomoya Murakami, Fumiki Okamoto, Masaharu Iida, Yoshimi Sugiura, Yoshifumi Okamoto, Takahiro Hiraoka & Tetsuro Oshika

Authors
  1. Tomoya Murakami
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  2. Fumiki Okamoto
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  3. Masaharu Iida
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  4. Yoshimi Sugiura
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  5. Yoshifumi Okamoto
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  6. Takahiro Hiraoka
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  7. Tetsuro Oshika
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Corresponding author

Correspondence to Fumiki Okamoto.

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No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Murakami, T., Okamoto, F., Iida, M. et al. Relationship between metamorphopsia and foveal microstructure in patients with branch retinal vein occlusion and cystoid macular edema. Graefes Arch Clin Exp Ophthalmol 254, 2191–2196 (2016). https://doi.org/10.1007/s00417-016-3382-2

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  • DOI: https://doi.org/10.1007/s00417-016-3382-2

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