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Intraocular cytokines imbalance in congenital cataract and its impact on posterior capsule opacification

  • Pediatrics
  • Published:
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Abstract

Background

Congenital cataract is of particular interest because of the variability of etiologies and the inflammatory reaction that are often observed. The aim of the study was to describe intraocular levels of various inflammation-related cytokines of patients with congenital cataract and to study their correlations with clinical determinants.

Methods

We followed a cohort of 18 patients (18 eyes) with congenital cataract from a University hospital and measured levels of various inflammation-related cytokines in the aqueous humor of patients with congenital cataract, and compared these levels to those observed in a control group (patients with senile cataract) using multiplex immunoassay. Correlation analysis was used to study the possible correlation between intraocular levels of cytokines and clinical determinants.

Results

Compared with the control group, the group with congenital cataract showed clear and significantly elevated concentrations of inflammatory markers (IL-1β, IL-15, IFN-γ, IL-12, IL-6, IL-5, IL-9, MIP-1α, MCP-1 and IP-10). Postoperative intraocular inflammation and opacification of the posterior capsule seemed to be correlated with preoperative IL-1β, TNF-α and IL-6 levels.

Conclusions

An inflammatory condition may occur in eyes with congenital cataract. The cytokine profiles are really different than those observed in senile cataract. Moreover, cytokines levels may be of interest to predict posterior capsule opacification and to complete the etiological workup.

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Authors and Affiliations

  1. Ophthalmology and Federation de Medecine Translationnelle de Strasbourg (FMTS), Strasbourg University Hospital, BP 426 – Nouvel Hôpital Civil, Strasbourg, France

    Arnaud Sauer, Tristan Bourcier, David Gaucher & Claude Speeg-Schatz

  2. Department of Parasitology, Strasbourg University Hospital, 3 Rue Koeberlé, 67000, Strasbourg, France

    Arnaud Sauer & Ermanno Candolfi

Authors
  1. Arnaud Sauer
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  2. Tristan Bourcier
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  3. David Gaucher
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  4. Ermanno Candolfi
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  5. Claude Speeg-Schatz
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Corresponding author

Correspondence to Arnaud Sauer.

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Funding

This study was done with governmental grants, “PHRC (Protocole Hospitalier de Recherche Clinique) 3964: Infections intraoculaires graves”. The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Electronic supplementary material

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Table 4

Means and standard deviations of cytokines and chemokines concentrations (pg/mL) in aqueous humor for right and left eyes in patients with bilateral congenital cataracts. (DOC 46 kb)

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Sauer, A., Bourcier, T., Gaucher, D. et al. Intraocular cytokines imbalance in congenital cataract and its impact on posterior capsule opacification. Graefes Arch Clin Exp Ophthalmol 254, 1013–1018 (2016). https://doi.org/10.1007/s00417-016-3313-2

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  • DOI: https://doi.org/10.1007/s00417-016-3313-2

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