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Minimally fibrotic stage 5 ROP: a clinical prognostic factor in eyes undergoing vitrectomy for stage 5 retinopathy of prematurity

  • Retinal Disorders
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Abstract

Title

Minimally fibrotic Stage 5: A clinical prognostic factor in eyes undergoing vitrectomy for stage 5 retinopathy of prematurity (ROP).

Purpose

To define minimally fibrotic stage 5 ROP and to demonstrate better surgical outcomes in this subgroup.

Methods

A cohort of eligible eyes with stage 5 ROP undergoing vitrectomy were further divided into those with minimally fibrotic stage 5 and others. Minimally fibrotic stage 5 ROP was defined as those stage 5 eyes having a translucent retrolental membrane with visibility of the underlying retinal vessels and absence of anteriorly rotated ciliary processes. We reported on anatomic and visual outcomes in eyes with defined characteristics of this subgroup identified before surgery and then observing them post vitrectomy over a period of time as compared to others.

Results

Minimally fibrotic stage 5 eyes had better visual (p = .0068) and anatomical outcomes (p = .0001).

Conclusion

Minimally fibrotic stage 5 ROP shows ridge to ridge traction that has resulted in a traction retinal detachment with a retrolental membrane, but fibrotic change has just begun. This stage 5 ROP with limited fibrosis represents a subset of this stage 5 ROP with a positive anatomic and visual prognosis.

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Acknowledgments

The authors are grateful to Dr. P M Velankar, senior anaesthetist who made the surgeries possible. The authors wish to thank Mr. Umesh Pawar, senior optometrist for the RetCam photographs. and Dr. Pravin Narwadkar for his invaluable assistance in coordinating the ROP project at our hospital.

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Authors and Affiliations

  1. Department of Vitreoretina surgery, PBMA’s H V Desai Eye Hospital, Hadapsar, Pune, 411060, India

    Salil S Gadkari, Madan Deshpande & Sucheta Kulkarni

Authors
  1. Salil S Gadkari
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  2. Madan Deshpande
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  3. Sucheta Kulkarni
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Corresponding author

Correspondence to Salil S Gadkari.

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No external funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Gadkari, S.S., Deshpande, M. & Kulkarni, S. Minimally fibrotic stage 5 ROP: a clinical prognostic factor in eyes undergoing vitrectomy for stage 5 retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 254, 1303–1309 (2016). https://doi.org/10.1007/s00417-015-3197-6

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  • DOI: https://doi.org/10.1007/s00417-015-3197-6

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