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Effect of rebamipide ophthalmic suspension on the success of lacrimal stent intubation

  • Oculoplastics and Orbit
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Abstract

Purpose

To evaluate the effect of the postoperative administration of rebamipide ophthalmic suspension on the success rate of lacrimal stent intubation (LSI) for the treatment of primary acquired nasolacrimal duct obstruction (PANDO).

Methods

This comparative interventional cohort study investigated 110 consecutive patients with PANDO who were treated with LSI and followed up for 12 months postoperatively at one institution. LSI was performed by one surgeon, and all patients received identical postoperative care. Among the total 110 patients, 71 underwent LSI with postoperative administration of rebamipide ophthalmic suspension, and 39 underwent LSI without administration of the suspension. Data related to patient age, gender, laterality, and postoperative administration of rebamipide ophthalmic suspension were collected and used as independent variables, and logistic regression analyses were performed to compare the anatomical success rate at 12 months postoperatively between patients with and without postoperative administration of the suspension.

Results

The anatomical success rate of LSI in patients with and without postoperative administration of rebamipide ophthalmic suspension was 90.1 and 69.2 %, respectively. A comparison of these success rates showed statistical significance, in that the rate of treatment success was higher in PANDO patients who underwent LSI with postoperative administration of the suspension [odds ratio (OR), 3.37; P < 0.05].

Conclusions

The findings of this study show that postoperative administration of rebamipide ophthalmic suspension increases the rate of anatomical success in patients who undergo LSI for the treatment of PANDO.

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Authors and Affiliations

  1. Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan

    Masashi Mimura, Mari Ueki, Hidehiro Oku & Tsunehiko Ikeda

  2. Department of Ophthalmology, Osaka Kaisei Hospital, Osaka, Japan

    Masashi Mimura & Bunpei Sato

Authors
  1. Masashi Mimura
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  2. Mari Ueki
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  3. Hidehiro Oku
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  4. Bunpei Sato
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  5. Tsunehiko Ikeda
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Corresponding author

Correspondence to Masashi Mimura.

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No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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For this type of study, formal consent is not required.

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Mimura, M., Ueki, M., Oku, H. et al. Effect of rebamipide ophthalmic suspension on the success of lacrimal stent intubation. Graefes Arch Clin Exp Ophthalmol 254, 385–389 (2016). https://doi.org/10.1007/s00417-015-3190-0

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  • DOI: https://doi.org/10.1007/s00417-015-3190-0

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