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Relationship between plasma levels of vasoactive mediators and optic nerve head circulation shown by laser speckle flowgraphy

  • Retinal Disorders
  • Published:
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Abstract

Propose

To evaluate relationships between optic nerve head (ONH) circulation by laser speckle flowgraphy (LSFG), and secretion levels of plasma norepinephrine (NE), plasma renin activity (PRA), plasma aldosterone concentration (PAC), and plasma cortisol.

Method

Forty subjects were included in the study. The mean blur rates (MBR) throughout the ONH (MBR–all), in the tissue (MBR–tissue), and in vessels (MBR–vessel) were analyzed. In 29 subjects the following parameters were evaluated: plasma NE and ONH circulation in the evening and morning (Δ plasma NE, Δ MBR–all, –tissue, –vessel, and Δ area ratio of blood stream).

Results

Plasma NE was significantly correlated with MBR–all (r = 0.39, P = 0.01) and MBR–vessel (r = 0.51, P = 0.0008). Plasma cortisol was significantly correlated with MBR–vessel (r =0.35, P = 0.03). The PRA (r = 0.31, P = 0.05) and PAC (r = 0.31, P = 0.05) tended to correlate with MBR–vessel. The multiple regression analysis revealed that plasma NE, PAC, and ocular perfusion pressure (OPP) were identified as factors contributing independently to the MBR–vessel (plasma NE: standard regression = 0.48, t-value = 3.12, P = 0.004; PAC: 0.43, 3.10, 0.04; OPP: 0.58, 2.34, 0.03, r = 0.71). Positive correlations between Δ plasma NE and Δ MBR–all (r = 0.46, P = 0.01), Δ MBR–tissue (0.38, 0.04), Δ MBR–vessel (0.41, 0.03), and Δ area ratio of blood stream (0.38, 0.04) were observed.

Conclusion

Our results clarified that the measurements of ONH circulation by LSFG is reflecting the plasma secretion levels of vasoactive mediators.

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Acknowledgments

The authors have no proprietary or financial interest in any aspect of this report.

Funding

No funding was received for this research.

Conflict of Interest

The authors have no financial conflicts of interest.

Ethical approval

The Institutional Review Board of Toho University Sakura Medical Center approved the study.

Informed consent

We began research after the participants provided informed consent in accordance with the Declaration of Helsinki.

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan

    Tomoaki Shiba, Yuichi Hori & Tadashi Matsumoto

  2. Nakano Eye Clinic of Kyoto Medical Co-operative, 2, Kyoto, Japan

    Tetsuya Sugiyama

  3. Department of Ophthalmology, Toho University Sakura Medical Center, Chiba, Japan

    Takatoshi Maeno

  4. Cardiovascular Center, Toho University Sakura Medical Center, Chiba, Japan

    Mao Takahashi

Authors
  1. Tomoaki Shiba
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  2. Tetsuya Sugiyama
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  4. Tadashi Matsumoto
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  5. Takatoshi Maeno
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  6. Mao Takahashi
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Correspondence to Tomoaki Shiba.

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Shiba, T., Sugiyama, T., Hori, Y. et al. Relationship between plasma levels of vasoactive mediators and optic nerve head circulation shown by laser speckle flowgraphy. Graefes Arch Clin Exp Ophthalmol 254, 1033–1039 (2016). https://doi.org/10.1007/s00417-015-3145-5

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  • DOI: https://doi.org/10.1007/s00417-015-3145-5

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