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Determination of absolute size of fundus objects

  • Basic Science
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Abstract

Background

Creating multiple beam interference fringes on the retina using the "retina fringe projector" (RFP) provides us with a scale which can be used to determine the absolute size of objects at the fundus.

Methods

The procedure is tested on an model eye, the optical parameters of which are varied in order to simulate different refraction conditions. The RFP was used to determine the size of a known object at the model fundus; the result was then checked against the real value of the object. In a second series of measurements, the RFP fringes were included in fundus photos of 52 patients with varying levels of ametropia, taken at the University Eye Clinic in Jena using the FF450 fundus camera (manufacturer: Carl Zeiss Meditec AG) for diagnostic purposes. The distance between the fringes was determined using both the RFP and the Littmann method.

Results

The differences to the real value of the fundus size of a known object deviated on average by 1 to 2%, and always remained under 3% in the model eye. A very good correlation between RFP and Littmann methods results could be found in the clinical part of the study. The resulting deviations are below 2.5%.

Conclusion

Integration of a RFP in a fundus camera permits measurement of absolute values of the retina, regardless of the type of observation or documentation. Knowing the real size of fundus objects holds a potential in many clinical classification scales of fundus objects such as drusen or vessels, or in optimizing photodynamic therapy spot size measurement.

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Authors and Affiliations

  1. Department of Ophthalmology, University Hospital Jena, Bachstr. 18, 07749 Bachstraße 18, 07740, Jena, Germany

    Jens Dawczynski & Jürgen Strobel

  2. University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, 07743, Jena, Germany

    Michael Gebhardt & Anne-Kathrin Schubert

  3. Carl Zeiss Meditec AG, Göschwitzer Str. 51-52, 07745, Jena, Germany

    Thomas Mohr & Ingo Koschmieder

  4. Department of Experimental Ophthalmology, University Hospital Hamburg, Martinistr. 52, 20246, Hamburg, Germany

    Bernhard Rassow

Authors
  1. Jens Dawczynski
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  2. Michael Gebhardt
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  3. Thomas Mohr
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  4. Ingo Koschmieder
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  5. Bernhard Rassow
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  6. Anne-Kathrin Schubert
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  7. Jürgen Strobel
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Corresponding author

Correspondence to Jens Dawczynski.

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Conflict of interest

None of the authors has any financial interest in any product or method mentioned in the text.

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Dawczynski, J., Gebhardt, M., Mohr, T. et al. Determination of absolute size of fundus objects. Graefes Arch Clin Exp Ophthalmol 249, 381–387 (2011). https://doi.org/10.1007/s00417-010-1498-3

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  • DOI: https://doi.org/10.1007/s00417-010-1498-3

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