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Measurement of retinal nerve fiber layer thickness in optic atrophy eyes of patients with optic neuritis using optical coherence tomography

  • Neuro-ophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Objective

To measure the retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) in optic atrophy eyes of patients with optic neuritis and investigate the correlation between the RNFL thickness and the visual function.

Methods

To compare the RNFL thickness using StratusOCT, three groups of the subjects were enrolled, including 72 patients with optic atrophy with definite demyelinating optic neuritis history (the neuritis group), 47 patients with advanced POAG atrophic neuropathy (the POAG group), and 47 healthy subjects (the control group). The correlation between the RNFL thickness and visual function parameters were investigated in the neuritis group, including the best-corrected visual acuity (BCVA), the visual field mean deviation (MD), pattern standard deviation (PSD), and P100 latency of visual evoked potentials (VEP).

Results

The average RNFL thickness, superior, nasal and inferior thicknesses were significantly thinner in both the neuritis group and the POAG group than those in the control group (p < 0.05), while they were higher in the neuritis group than the POAG group (p < 0.05). The significant correlations were found both between the average RNFL thickness and BCVA (r = 0.35, p < 0.05), MD (r = 0.43, p < 0.05), and PSD (r = 0.39, p < 0.05).

Conclusion

In comparison to the advanced POAG and normal eyes, the RNFL thickness was decreased moderately in the optic atrophy eyes resulting from demyelinating optic neuritis and was quantitatively correlated with the visual function parameters.

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Authors and Affiliations

  1. Department of Ophthalmology, the Forth Affiliated Hospital, China Medical University, 11 Xinhua Road, Heping District, Shenyang, 110005, China

    Xin-Ling Wang, De-Zhao Xia, Jin-Song Zhang & Qi-chang Yan

  2. Key Laboratory of Lens of Liaoning Province, China, 11 Xinhua Road, Heping District, Shenyang, 110005, China

    Xin-Ling Wang, De-Zhao Xia, Jin-Song Zhang & Qi-chang Yan

  3. Department of Medical Image, Liaoning Cancer Hospital & Institute, 44 Xiaoheyan Road, Dadong District, Shenyang, 110042, China

    Tao Yu & Ya-Hong Luo

Authors
  1. Xin-Ling Wang
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  2. Tao Yu
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  3. De-Zhao Xia
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  4. Jin-Song Zhang
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Correspondence to Xin-Ling Wang or Tao Yu.

Additional information

Xin-Ling Wang and Tao Yu contributed equally to this work.

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Wang, XL., Yu, T., Xia, DZ. et al. Measurement of retinal nerve fiber layer thickness in optic atrophy eyes of patients with optic neuritis using optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 248, 1013–1018 (2010). https://doi.org/10.1007/s00417-010-1326-9

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  • DOI: https://doi.org/10.1007/s00417-010-1326-9

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