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Functional changes following combined intravitreal bevacizumab and photodynamic therapy for polypoidal choroidal vasculopathy

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To assess the functional changes of retina in patients affected by polypoidal choroidal vasculopathy (PCV) after combined intravitreal bevacizumab and photodynamic therapy (PDT) by means of contrast sensitivity (CS) test and color vision test.

Methods

Twelve eyes of 12 patients were included in the study. The CS and color vision were measured and compared before the combined treatment and 1, 3 and 6 months after the treatment.

Results

The patients had an improvement in CS over pre-treatment values at the all of the five spatial frequencies. And the differences at 1.5 cycle per degree (cpd) at 1 and 3 months after treatment (p = 0.04 and 0.007 respectively) were statistically significant. The mean square root of total error score for color vision of the FM 100-hue test decreased after treatment and the change was significant at 3 and 6 months after treatment (p < 0.001 and 0.011 respectively).

Conclusions

Combined intravitreal bevacizumab and PDT can improve the CS at low spatial frequency and color vision in patients affected by PCV, although the significant increases of CS were no longer found at 6-month follow-up.

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References

  1. Yannuzzi LA, Ciardella A, Spaide RF, Rabb M, Freund KB, Orlock DA (1997) The expanding clinical spectrum of idiopathic polypoidal choroidal vasculopathy. Arch Ophthalmol 115:478–485

    CAS  PubMed  Google Scholar 

  2. Yannuzzi LA, Sorenson J, Spaide RF, Lipson B (1990) Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina 10:1–8

    Article  CAS  PubMed  Google Scholar 

  3. Kurashige Y, Otani A, Sasahara M, Yodoi Y, Tamura H, Tsujikawa A, Yoshimura N (2008) Two-year results of photodynamic therapy for polypoidal choroidal vasculopathy. Am J Ophthalmol 146:513–519

    Article  PubMed  Google Scholar 

  4. Lee SY, Kim JG, Joe SG, Chung H, Yoon YH (2008) The therapeutic effects of bevacizumab in patients with polypoidal choroidal vasculopathy. Korean J Ophthalmol 22:92–99

    Article  PubMed  Google Scholar 

  5. Lai TY, Chan WM, Liu DT, Luk FO, Lam DS (2008) Intravitreal bevacizumab (Avastin) with or without photodynamic therapy for the treatment of polypoidal choroidal vasculopathy. Br J Ophthalmol 92:661–666

    Article  CAS  PubMed  Google Scholar 

  6. Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Oshima Y, Kamei M, Tano Y (2008) Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy. Br J Ophthalmol 92:70–73

    Article  CAS  PubMed  Google Scholar 

  7. Mauget-Faysse M, Quaranta-El Maftouhi M, De La Marnierre E, Leys A (2006) Photodynamic therapy with verteporfin in the treatment of exudative idiopathic polypoidal choroidal vasculopathy. Eur J Ophthalmol 16:695–704

    CAS  PubMed  Google Scholar 

  8. Quaranta M, Mauget-Faysse M, Coscas G (2002) Exudative idiopathic polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin. Am J Ophthalmol 134:277–280

    Article  PubMed  Google Scholar 

  9. Stifter E, Sacu S, Thaler A, Weghaupt H (2006) Contrast acuity in cataracts of different morphology and association to self-reported visual function. Invest Ophthalmol Vis Sci 47:5412–5422

    Article  PubMed  Google Scholar 

  10. Scott IU, Feuer WJ, Jacko JA (2002) Impact of visual function on computer task accuracy and reaction time in a cohort of patients with age-related macular degeneration. Am J Ophthalmol 133:350–357

    Article  PubMed  Google Scholar 

  11. Bansback N, Czoski-Murray C, Carlton J, Lewis G, Hughes L, Espallargues M, Brand C, Brazier J (2007) Determinants of health related quality of life and health state utility in patients with age related macular degeneration: the association of contrast sensitivity and visual acuity. Qual Life Res 16:533–543

    Article  CAS  PubMed  Google Scholar 

  12. Moorthy RS, Lyon AT, Rabb MF, Spaide RF, Yannuzzi LA, Jampol LM (1998) Idiopathic polypoidal choroidal vasculopathy of the macula. Ophthalmology 105:1380–1385

    Article  CAS  PubMed  Google Scholar 

  13. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group (1999) Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials—TAP report. Arch Ophthalmol 117:1329–1345

    Google Scholar 

  14. Kinnear PR (1970) Proposals for scoring and assessing the 100-Hue test. Vis Res 10:423–433

    Article  CAS  PubMed  Google Scholar 

  15. Tatar O, Kaiserling E, Adam A, Gelisken F, Shinoda K, Volker M, Lafaut BA, Bartz-Schmidt KU, Grisanti S (2006) Consequences of verteporfin photodynamic therapy on choroidal neovascular membranes. Arch Ophthalmol 124:815–823

    Article  CAS  PubMed  Google Scholar 

  16. Tatar O, Adam A, Shinoda K, Stalmans P, Eckardt C, Luke M, Bartz-Schmidt KU, Grisanti S (2006) Expression of VEGF and PEDF in choroidal neovascular membranes following verteporfin photodynamic therapy. Am J Ophthalmol 142:95–104

    Article  CAS  PubMed  Google Scholar 

  17. Meyer CH, Lapolice DJ, Fekrat S (2005) Functional changes after photodynamic therapy with verteporfin. Am J Ophthalmol 139:214–215

    Article  PubMed  Google Scholar 

  18. Kumar A, Gopalakrishnan K, Sinha S (2008) Combination photodynamic therapy and intravitreal ranibizumab in neovascular AMD in a north Indian population: a pilot study. Retina 28:1132–1137

    Article  PubMed  Google Scholar 

  19. Azad RV, Khan MA, Chanana B, Azad S (2008) Intravitreal bevacizumab for subfoveal choroidal neovascularization secondary to age-related macular degeneration in an Indian population. Jpn J Ophthalmol 52:52–56

    Article  CAS  PubMed  Google Scholar 

  20. Ziemssen F, Luke M, Bartz-Schmidt KU, Gelisken F (2008) Time-dependent effects on contrast sensitivity, near and distance acuity: difference in functional parameters? (Prospective, randomized pilot trial of photodynamic therapy versus full macular translocation). Graefes Arch Clin Exp Ophthalmol 246:653–659

    Article  PubMed  Google Scholar 

  21. Chaudhary V, Mao A, Hooper PL, Sheidow TG (2007) Triamcinolone acetonide as adjunctive treatment to verteporfin in neovascular age-related macular degeneration: a prospective randomized trial. Ophthalmology 114:2183–2189

    Article  PubMed  Google Scholar 

  22. Rocha KM, Soriano ES, Chalita MR, Yamada AC, Bottos K, Bottos J, Morimoto L, Nose W (2006) Wavefront analysis and contrast sensitivity of aspheric and spherical intraocular lenses: a randomized prospective study. Am J Ophthalmol 142:750–756

    Article  PubMed  Google Scholar 

  23. Owsley C, Sloane ME (1987) Contrast sensitivity, acuity, and the perception of ‘real-world’ targets. Br J Ophthalmol 71:791–796

    Article  CAS  PubMed  Google Scholar 

  24. Marmor MF, Gawande A (1988) Effect of visual blur on contrast sensitivity. Clinical implications. Ophthalmology 95:139–143

    CAS  PubMed  Google Scholar 

  25. Sjostrand J (1979) Contrast sensitivity in macular disease using a small-field and a large-field TV-system. Acta Ophthalmol (Copenh) 57:832–846

    Article  CAS  Google Scholar 

  26. Hyvarinen L, Laurinen P, Rovamo J (1983) Contrast sensitivity in evaluation of visual impairment due to macular degeneration and optic nerve lesions. Acta Ophthalmologica 61:161–170

    Article  CAS  PubMed  Google Scholar 

  27. Mitra S (1985) Spatial contrast sensitivity in macular disorder. Doc Ophthalmol 59:247–267

    Article  CAS  PubMed  Google Scholar 

  28. Ziemssen F, Luke M, Messias A, Beutel J, Tatar O, Zrenner E, Bartz-Schmidt KU (2008) Safety monitoring in bevacizumab (Avastin) treatment: retinal function assessed by psychophysical (visual fields, colour vision) and electrophysiological (ERG/EOG) tests in two subgroups of patients. Int Ophthalmol 28:101–109

    Article  PubMed  Google Scholar 

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Acknowledgements

This study was supported by the National Basic Research Program of China (Grant No. 2007CB512206).

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Authors and Affiliations

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, 510060, People’s Republic of China

    Chengguo Zuo, Feng Wen, Jiaqing Li, Yan Liu, Shixian Long, Shizhou Huang & Meng Li

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  1. Chengguo Zuo
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  2. Feng Wen
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  3. Jiaqing Li
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  4. Yan Liu
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  5. Shixian Long
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  6. Shizhou Huang
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  7. Meng Li
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Correspondence to Feng Wen.

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Zuo, C., Wen, F., Li, J. et al. Functional changes following combined intravitreal bevacizumab and photodynamic therapy for polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol 248, 191–196 (2010). https://doi.org/10.1007/s00417-009-1210-7

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  • DOI: https://doi.org/10.1007/s00417-009-1210-7

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