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Early changes of vascular lesions and responses to combined photodynamic therapy in patients with polypoidal choroidal vasculopathy

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Abstract

Purpose

To evaluate early changes of vascular lesions and their associations with the early responses to combined photodynamic therapy (PDT) in eyes with polypoidal choroidal vasculopathy (PCV).

Methods

This study evaluated 19 eyes of 19 patients with PCV who underwent PDT combined with anti-vascular endothelial growth factor injections and were followed for 3 months. All subjects were examined 1 week and 1, 2, and 3 months after combined PDT. “Active” cases were defined as recurrence or persistence of serous retinal detachment or subretinal hemorrhage detected within 3 months. Branching vascular networks (BVNs) were evaluated by optical coherence tomography angiography (OCTA) and polyps by indocyanine-green angiography.

Results

In total, 16%, 58%, 84%, and 89% of eyes displayed BVNs 1 week, 1, 2, and 3 months after PDT, respectively. BVNs were detected significantly more often 1 month after PDT in the “active” group than “inactive” group (89% vs. 30%, p = 0.020). There were significantly higher overall proportions of BVNs detected by OCTA in the “active” group than “inactive” group (p = 0.0058).

Conclusion

In most cases, BVNs disappeared once and gradually appeared again within 3 months. Detecting BVNs using OCTA from early phases could be a helpful biomarker to assess the early responses to PDT in eyes with PCV.

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Funding

This study was funded by Japan Society For The Promotion of Science (Grant Number 18K18413). The funding organization had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Kimiko Asano-Shimizu, Shotaro Asano, Hiroshi Murata, Keiko Azuma, Yoko Nomura, Tatsuya Inoue, Asako Ogawa, Ryo Asaoka & Ryo Obata

Authors
  1. Kimiko Asano-Shimizu
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  2. Shotaro Asano
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  3. Hiroshi Murata
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  4. Keiko Azuma
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  7. Asako Ogawa
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Correspondence to Ryo Obata.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Asano-Shimizu, K., Asano, S., Murata, H. et al. Early changes of vascular lesions and responses to combined photodynamic therapy in patients with polypoidal choroidal vasculopathy. Int Ophthalmol 40, 1335–1345 (2020). https://doi.org/10.1007/s10792-020-01299-3

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  • DOI: https://doi.org/10.1007/s10792-020-01299-3

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