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Stereoscopic visual evoked potentials in normal subjects and patients with open-angle glaucomas

  • Clinical Investigation
  • Published:
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Abstract

Purpose

To evaluate stereoscopic visual evoked potentials (S-VEP) in normal controls and in patients with glaucomatous optic nerve damage.

Methods

Computer-generated dynamic random-dot stereograms were used to elicit cortical visual evoked potentials using wireless electric liquid crystal shutter glasses. Normal subjects (n=22) and patients with glaucoma (n=22) were investigated using five different disparities from 9 to 40 arc min. Statistical dependency of measurements with different stimulus at identical patients was adjusted for.

Results

Peak times of onset and offset response of S-VEP can be significantly delayed in glaucomas. A general linear regression model confirmed that differences between patients and normals depend on disparity. S-VEP onset shows no significant difference between controls and glaucomas at 9 arc min disparity. At high disparities, however, peak time of the onset response was significantly (p<0.01) delayed in glaucomas when compared with normals (normals: 125.8±13 ms, glaucomas: 148.2±25.6 ms at 40 arc min).

Conclusions

Visual evoked potential elicited by the onset of a random-dot stereogram can be used for objective measurement of stereoacuity in a clinical setting. Differences between controls and glaucomas in high and low disparities could indicate a stereo-specific deficit in glaucoma.

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Acknowledgements

This study was supported by DFG, grant SFB 539. We thank J. Jonas and W. Budde for classification of the optic nerve morphology.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 , Erlangen, Germany

    Antonio Bergua, Folkert K. Horn, Anselm M. Jünemann & Matthias Korth

  2. Institute for Medical Informatics, Biometry and Epidemiology, Benjamin Franklin Medical School, Free University Berlin, Berlin, Germany

    Peter Martus

Authors
  1. Antonio Bergua
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  2. Folkert K. Horn
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  3. Peter Martus
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  4. Anselm M. Jünemann
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  5. Matthias Korth
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Corresponding author

Correspondence to Antonio Bergua.

Additional information

The authors have no commercial interest in the equipment used in this work. This paper was presented at the ARVO 2000 in poster form

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Bergua, A., Horn, F.K., Martus, P. et al. Stereoscopic visual evoked potentials in normal subjects and patients with open-angle glaucomas. Graefe's Arch Clin Exp Ophthalmol 242, 197–203 (2004). https://doi.org/10.1007/s00417-003-0797-3

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  • DOI: https://doi.org/10.1007/s00417-003-0797-3

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