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Potential risk factors of persistent postural-perceptual dizziness: a pilot study

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  • Published:
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Abstract

Background

Persistent postural-perceptual dizziness (PPPD) unifies the main characteristics of chronic subjective dizziness, visual vertigo and related diseases, which is a common chronic disease in neurology. At present, the pathology of PPPD is not fully understood.

Objective

In this single-center retrospective case series review, we aim to investigate the potential risk factors of PPPD.

Methods

Eighty inpatients diagnosed with PPPD were recruited with 81 apparently healthy controls. Patient-specific clinico-radiological data were collected from both groups. Conditions of hypertension, diabetes, smoking, and drinking were derived from medical history. Blood test results were recorded including total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fibrinogen, vitamin B12, folic acid, total cholesterol, triglyceride, and folate level. The subjects were examined by carotid artery CTA and cranial MRI, and the imaging findings of carotid atherosclerosis (CAS), white matter hyperintensities (WMHs) and lacunar infarction (LI) were recorded. Binary logistic regression analysis was used to investigate the difference between the case and control groups. Significance was defined as p value less than 0.05.

Results

The prevalence rate of hypertension in the case group was significantly higher than that in the control group, and the detection rates of CAS, WMHs, and LI in the case group were significantly higher than those in the control group (p < 0.05 for all).

Conclusion

Hypertension, CAS, WMHs, and LI are associated with PPPD, which may be potential risk factors for its development.

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Data availability statement

The data are available from the corresponding author.

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Acknowledgements

The author would like to thank the radiology department for their help.

Funding

This research was funded by Medical Health Science and Technology Project of Zhejiang Provincial Health Commission and Planned Projects of Bureau of Science and Technology of Zhoushan, Grant number 2020ZH065, 2020C31048.

Author information

Authors and Affiliations

  1. Department of Neurology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, 316000, Zhejiang Province, China

    Ling Li, Songbin He & Fangyu Dai

  2. Research Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, UK

    Haipeng Liu

  3. Naval Hospital of Eastern Theater, Zhoushan, 316000, Zhejiang Province, China

    Meilun Pan

Authors
  1. Ling Li
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  2. Songbin He
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  3. Haipeng Liu
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  4. Meilun Pan
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  5. Fangyu Dai
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Contributions

Conceptualization: LL, FD, and SH; methodology: FD and HL; formal analysis and investigation: LL, FD, SH, HL, and MP; writing—original draft preparation: LL and HL; funding acquisition: FD; resources: LL, FD, SH, and MP; supervision: FD, SH, and HL.

Corresponding authors

Correspondence to Haipeng Liu or Fangyu Dai.

Ethics declarations

Conflicts of interest

Corresponding authors declare on behalf of all the authors that there is no conflict of interest.

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Zhoushan Hospital (Date 27 May 2021/ No.20210013).

Informed consent

The clinical and radiological data were retrospectively retrieved from existing datasets. The data were anonymized before analysis. Informed consent form was waived by local ethics committee.

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Li, L., He, S., Liu, H. et al. Potential risk factors of persistent postural-perceptual dizziness: a pilot study. J Neurol 269, 3075–3085 (2022). https://doi.org/10.1007/s00415-021-10899-7

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  • DOI: https://doi.org/10.1007/s00415-021-10899-7

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