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Safeguarding genetic information in Drosophila

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Abstract

Eukaryotic cells employ a plethora of conserved proteins and mechanisms to ensure genome integrity. In metazoa, these mechanisms must operate in the context of organism development. This mini-review highlights two emerging features of DNA damage responses in Drosophila: a crosstalk between DNA damage responses and components of the spindle assembly checkpoint, and increasing evidence for the effect of DNA damage on the developmental program at multiple points during the Drosophila life cycle.

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Acknowledgments

I thank the members of my lab for helpful critical comments. The work in the Su Lab is funded by a grant from the NIH (GM87276) to T.T.S.

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  1. MCD Biology, University of Colorado, Boulder, CO, 80309-0347, USA

    Tin Tin Su

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Su, T.T. Safeguarding genetic information in Drosophila . Chromosoma 120, 547–555 (2011). https://doi.org/10.1007/s00412-011-0342-9

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  • DOI: https://doi.org/10.1007/s00412-011-0342-9

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