Abstract
The dose limit for the skin of the hand is typically converted to a surface of 1 cm2, which means that one needs to measure point doses in different places on the hand. However, the commonly used method of measuring doses on the hand, i.e., using a dosimetric ring including one or several thermoluminescent detectors worn at the base of a finger, is not adequate for manual procedures such as labeling or radiopharmaceutical injection. Consequently, the purpose of this study was to create and conduct a series of computer simulations that, by recreating the actual working conditions, would provide information on the values of ionizing radiation doses received by the most exposed parts of the hands of employees of radiopharmaceutical production facilities, as well as those of nurses during the injection of radiopharmaceuticals. The simulations were carried out using Monte Carlo radiation transport calculations. The Hp(0.07) personal dose equivalent values obtained for the fingertips of the index and middle fingers of nursing staff and chemists were within the range limited by the minimum and maximum Hp(0.07) values obtained as a result of dosimetric measurements carried out in diagnostic and production centers. Only in the case of the nurse’s fingertip, the simulated value of Hp(0.07 slightly exceeded the measured maximum Hp(0.07) value. The comparison of measured and simulated dose values showed that the largest differences in Hp(0.07) values occurred at the thumb tip, and for ring finger and middle finger of some of the nurses investigated.
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Introduction
Nuclear medicine is an interdisciplinary field and, therefore, a rather unusual branch of medicine. For example, a wide range of radionuclides are used, with various physical half-lives, and multiple methods of their preparation are needed. Very often, manual preparation of radiopharmaceuticals means that personnel employed in the field of nuclear medicine can be exposed to extremely high doses of ionizing radiation, especially when it comes to hand exposure. Significant difficulties in assessing the magnitude of this exposure result from the fact that fingertips are the most exposed areas, which is a consequence of the highly non-homogeneous distribution of doses on the skin of the hands and fingers.
Because the dose limit for the skin is converted to 1 cm2 of skin surface, one needs to measure point doses in different places on the hand. The commonly used method of measuring doses on the hand, i.e., using a dosimetric ring containing one or several thermoluminescent detectors worn at the base of a finger, however, is not adequate for manual procedures such as labeling or radiopharmaceutical injection (Martin and Sutton 2015; Wrzesień and Olszewski 2018; Sherbini et al. 2011; Lecchi et al. 2016; Jankowski et al. 2002; Sæther et al. 2005; Smart 2004; Chiesa et al. 1997; Donadille et al. 2005; Vanhavere et al. 2006; Batchelor et al. 1991; Montgomery et al. 1999; Hastings et al. 1997; Wrzesień and Olszewski 2011; Carnicer et al. 2011; Wrzesień et al. 2008, 2016; Kubo and Mauricio 2014). Unfortunately, dosimetric literature data on medical personnel who work with ionizing radiation in nuclear medicine facilities using positron emission tomography (PET) is typically limited to cases, where the exposure of personnel performing 18F-FDG injection procedures to the patient or diagnostic procedures has been analyzed (Leide-Svegborn 2010, 2011; Dalianis et al. 2006; Sandouqa et al. 2011; Antic et al. 2014; Wrzesień and Napolska 2015). When planning radiological protection for employees, it would be worth having at least approximate information about the dose values obtained by the most exposed parts of the hand. To this end, computer simulations can be used to obtain this information.
Currently, there are nine centers in Poland that produce 18F-FDG, and at least 16 medical facilities equipped with PET-CT hybrid devices. Interestingly, recently a group of independent experts expressed the view, after considering the epidemiology of cancer in individual European countries, that there should be 28 centers in Poland, each carrying out approximately 2000 examinations/year (Królicki et al. 2011). Thus, it is expected that the number of such centers will increase in the future, in Poland, highlighting the need for predicting the personnel exposure before it occurs.
Over the past decade, standard diagnostic imaging has increasingly involved procedures that use the PET technique (Królicki et al. 2011; Piciu 2012), which has increased the need for radiopharmaceuticals, especially fluorine-18 in the form of 18F-FDG. In turn, this development has increased the number of staff working in radiopharmaceutical production. However, the increase in the number of the patients diagnosed with 18F-FDG affects the doses received by nurses during the injection.
The analysis carried out as part of the ORAMED project (Vanhavere et al. 2012) regarding the exposure of the hands of nuclear medicine personnel is an important voice in the discussion on radiation protection aspects of this professional group. However, that project focused on manual deoxyglucose labeling procedures using 18F. In contrast, in Poland the labeling process has been automated and manual operations involving fluorodeoxyglucose include only the handling of 18F-FDG activity for the purposes of quality control of the finished products (Wrzesień et al. 2016).
The automation of the production process of the 18F positron marker and the automatic process of labeling deoxyglucose with the produced 18F contribute to the optimization of radiation protection, because both the number of employees and the time of contact with the radioisotope is reduced to the necessary minimum. However, this does not mean the complete elimination of manual procedures that involve the radioisotope. In fact, there are still procedures in the 18F-FDG production process that require manual intervention by an employee, in particular the quality control of the radiopharmaceutical. This is an important production stage, whose speed and effectiveness of implementation determine the release of the prepared product for further stages of production, including radiopharmaceutical injection to the patient. The procedures to be performed as part of the quality control are specified in the European Pharmacopoeia (2017), together with a description of their proper implementation.
All manual procedures carried out by employees responsible for quality control, as well as nurses injecting the radiopharmaceutical, mean working with an open source of ionizing radiation, which is 18F-FDG located in a vial or syringe. This work is the main source of exposure for chemists responsible for the quality control of 18F-FDG, and nurses.
The activity of radiopharmaceutical that is used at the beginning of any quality control procedure or the average 18F-FDG activity (regulated by reference levels) (Atomic Law 2019; COUNCIL DIRECTIVE 2013/59/EURATOM 2013) administered to a single patient, as well as the relatively short physical half-life (110 min) of 18F are the (physical) parameters that affect the dose that the employee’s fingertips receive during the work with 18F.
Currently, simulation methods are used in many fields of science including nuclear medicine and other branches of medicine that use ionizing radiation. The benefits of simulations are especially obvious in cases of inhomogeneous radiation fields, where measurements can be difficult, time consuming or not feasible at all (Becker et al. 2011). As stated by Becker et al., “Different scenarios can be simulated and situations with highest exposures can be revealed” (Becker et al. 2011). Simulations using voxel phantoms or flexible mathematical phantoms are useful tools for studying hand exposure (Becker et al. 2008a, b, 2011, 2014; Blunck et al. 2009, 2011; Becker and Blunck 2011; Figueira et al. 2013).
The purpose of the present study was to perform a series of computer simulations using the GEANT4 library package. By recreating the actual working conditions this allowed to obtain information on the radiation doses that are received by the most exposed parts of the hands of employees of radiopharmaceuticals production centres, as well as by nurses during injection. Information on working conditions and physical parameters affecting the level of recorded doses was obtained by physical measurements, which allowed verification of the dose values obtained by simulation.
Materials and methods
Simulation part
The simulations were carried out using the Monte Carlo method (Andreo 1991; Konefał 2006). For this purpose, the GEANT4 toolkit version 4.10.2 (GEometry ANd Tracking) was used to simulate the interaction of particles with matter (Agostinelli et al. 2003). Individual components of the created computer simulation are presented in the following sections.
Simulation “world”
To create the “world”, the built-in G4Box function was used and a cube with side a = 100 cm was implemented. The world was filled with air using the G4LogicalVolume and G4_AIR functions.
Worker’s hand
The process of creating an employee’s hand was multi-stage and consisted of several steps. The first was the choice of the hand model. For this it was important to realize that dosimetry measurements suggested that the quality control procedure and radiopharmaceutical injection have the greatest impact on the dose to the fingertips of personnel (Wrzesień et al. 2016, 2018; Wrzesień 2018a, b). Taking into account the fact that 70% of employees performing the above-mentioned procedures are women, the dimensions of the female hand model were used to construct the hand model. Hand dimensions (i.e., length, width, thickness, girth and radius of the palms) were selected from the corresponding 95th percentiles. Required data were taken from the atlas of human measures (Gedliczka 2001).
Based on this a mathematical hand model was created using geometric solids. The pastern was represented by a cuboid with the dimensions of a = 3.2 cm, b = 8.8 cm, and c = 11.7 cm (Gedliczka 2001). Individual fingers were built using the G4ElipticalTube function. Each of the fingers was composed of two phalanges. Pasterns and phalanges were uniformly filled with G4_SKIN_ICRP material from the embedded material database available in the GEANT4 package.
Syringe model
Quality control and radiopharmaceutical injection procedures are typically performed manually using a syringe. The activity accumulated in the syringe during manual operations, as well as the time needed to perform the appropriate procedure, determine the exposure of the hand to ionizing radiation, which is minimized by the use of an appropriate syringe cover. In the simulations a 9 mm tungsten shield was used. Figure 1 shows the developed syringe model and the dominant hand.
The syringe was modeled in the form of a hollow cylinder with an internal diameter of 10 mm (which simulates the inside of syringe), an external diameter of 29 mm (simulating the syringe shield), and a length of 100 mm. The plunger of the syringe was covered with a filled roller, 9 mm thick. Both the shield and roller were filled homogeneously with tungsten. The cylinder simulating the syringe plunger was filled homogeneously with air.
18F radionuclide simulation in a syringe
Fluor-18 was created using the G4ParticleDefinition class. The 18F isotope was defined using corresponding mass and atomic numbers. The first atom was generated in the center of the syringe, and the next ones were created in a random position in relation to the originally created atom. Considering the processes of 18F decay, which involves creation of a positron with electron annihilation, and interaction of γ radiation with matter, required the use of various GEANT4 libraries: G4EmStandardPsychics, G4DecayPhysics and G4RadioactiveDecayPhysics. The neutrino resulting from the decay of the β+ atom 18F was eliminated from further processes, because it does not contribute to dose. This shortened the computer time needed for the simulation.
The 18F activity is determined by specifying the initial number of nuclei that undergo radioactive decay over time. In the present study, a typical average working time with an open source of radiation of 120 s was assumed, as well as an average activity with which the workers typically work of 300 MBq.
Simulation of doses
In principle, the simulations provided absorbed doses to the hand. At first, the simulations were carried out dozens of times for each of the given number of 18F nuclei of 100, 1000, 10,000, etc., respectively. The obtained values of absorbed doses for a given finger were averaged, and then the functional dependence of the absorbed dose and the number of 18F nuclei used in the simulation was plotted. Finally, the slope of this functional dependence was calculated for each finger considering that 3.6 × 1010 fluorine 18F nuclei correspond to an activity of 300 MBq. These slope values obtained (which provided absorbed dose to each finger per Bq of 18F activity) were used to calculate absorbed doses to each finger of the dominant hand, for any given radiopharmaceutical activity. Statistical uncertainties were smaller than the symbols shown in Fig. 2.
Comparison of measured with simulated doses required the conversion of the absorbed dose value into a personal dose equivalent Hp(0.07) value [because dosemeters used for those dose measurements are typically calibrated in terms of Hp(0.07)]. For this purpose, the radiation quality factor Q(L) = 1 for gamma radiation was used.
Dosimetric measurements
To validate the results of the Monte Carlo simulations, Hp(0.07) was measured in three PET-CT diagnostic facilities and in two facilities producing 18F-FDG radiopharmaceutical. Diagnostic centers are identified here as PET along with a number representing a certain facility. These facilities had also provided the data used in the present simulations, such as the activity of the radiopharmaceutical, the length of time an employee is typically exposed to 18F, and the technical data regarding the syringe. The measurements included highly sensitive MCP-N (LiF: Mg, Cu, P) thermoluminescence detectors manufactured by Radcard (Kraków, Poland). The detectors were calibrated in accordance with ISO 4037-3 (ISO 2019) as described in (Wrzesień et al. 2016, 2018; Wrzesień 2018a, b; Wrzesień and Napolska 2015). In total, 22 workers were included in the dosimetry measurements, including four physicists, nine chemists and nine nurses. The detectors were placed at 12 points of the palm side of both hands, namely on the fingertip of the thumb, index finger, middle finger, middle finger and small finger, and additionally at the base of the middle finger.
Results
Figure 2 shows an example for the thumb of the relationship between the absorbed dose value and the number of 18F nuclei used in the simulation.
Analysis of the results obtained showed that for each of the modeled fingers, there exists a linear relationship between the number of atoms of the 18F radionuclide for which the simulations were carried out, and the value of the absorbed dose obtained. The R2 coefficients for the curves, determined for each of the fingers, were typically 0.99.
From these curves the slopes were obtained, for each of the five fingers.
Table 1 presents the values of these slopes for each of the fingers modeled in the simulation using the GEANT4 toolkit. These slope values allowed, taking into account the actual activity of the radiopharmaceutical, to calculate the value of absorbed doses for each of the five fingers of the dominant hand. The obtained results are presented in Table 1.
Discussion
To validate the dose values obtained by the MC simulations, results of dosimetric measurements obtained for one of the nurses from the PET I centre, for two nurses from the PET II centre, and for a chemist performing the quality control procedure at the RPC I centre were used. For these measurements, procedures selected during which the 18F activity in the employee’s syringe was about 300 MBq. Table 2 presents personal dose equivalent Hp(0.07) values obtained by dosimetric measurements and computer simulations. The results presented in Table 2 lead to the following conclusions.
The simulations allow correct identification of the most exposed fingertips of the dominant hand of nurses injecting 18F-FDG and chemists performing radiopharmaceutical quality control. The Hp(0.07) values obtained by simulation of the fingertips of index and middle fingers of nurses and chemists are within the limited range of minimum and maximum values obtained as a result of the dose measurements. Only in the case of the nurse’s ring fingertip, the Hp(0.07) value obtained in the simulation slightly exceeds the maximum Hp(0.07) value measured at PET II. The largest differences between measured and simulated Hp(0.07) values were obtained for the thumb, for the ring finger of the nurse at PET I, and for the middle finger of the nurse at PET II.
In the case of the thumb, the observed difference between measured and simulated values can be explained by the change in position of the syringe plunger during the radiopharmaceutical injection procedure. The thumb presses on the plunger, forcing the radiopharmaceutical in the syringe into the patient’s vein. Note that in the simulation it was assumed that the piston of the syringe is stationary.
The second critical feature of computer model that affects the simulated results is the design of the syringe shield. For the GEANT4 simulations, both the body of the syringe and the part, where the plunger is located was assumed to be shielded. The implemented shield was a small cylinder filled with tungsten with a diameter corresponding to the diameter of the syringe, and with a thickness of several millimeters. The application of this shield resulted in the protection of the thumb against gamma radiation emitted from the side of the syringe piston. Such kind of are not used in production and diagnostic facilities. The results of the computer simulations can also be compared with dosimetric data published by other researchers. Table 3 summarizes the results of measurements regarding normalized values of Hp(0.07) obtained during handling of 18F-FDG.
Conclusions
The simulations performed for assessment of the exposure of the dominant hand of nursing staff in PET centers and chemists in radiopharmaceutical production centers correctly predicted exposure to ionizing radiation resulting from the handling of a syringe containing 18F. Created based on the atlas of human measures, the mathematical hand model turned out to be a sufficient tool to assess exposure in the cases described in the present work. The personal dose equivalent Hp(0.07) values to fingertips of employees obtained by application of the developed Monte Carlo method are mostly consistent with the results of dosimetric measurements carried out in PET diagnostic facilities and radiopharmaceuticals production centers. The actual dose values derived from these measurements, which depend on the radiopharmaceutical activity and the time needed to perform the required manual activities, proved valuable information about the doses for the most exposed parts of the employees’ hand.
The simulation algorithm created using the GEANT4 toolkit correctly identified the most exposed parts of the hand performing manual operations using a syringe containing 18F-FDG. The use of a ring dosimeter as part of routine measurements provides only partial information about fingertip exposure. In contrast, the use of computer simulations does allow the assessment of fingertip exposure and thus also the planning of radiation protection not only in the context of dose values but also in terms of the number of personnel carrying out manual procedures for radiopharmaceutical quality control and injections. Furthermore, changing the type of radionuclide that is the source of exposure in the simulation allows the method to be used in both conventional nuclear medicine facilities and centers producing short-lived radionuclides. Therefore, it seems reasonable to state that a properly constructed simulation can serve as a tool to support the work of radiological protection inspectors by predicting potential exposure in selected manual procedures and thus optimizing radiation protection before this exposure occurs.
References
Agostinelli S, Allison J, Amako K, Apostolakis J, Araujo H, Arce P, Asai M, Axen D, Banerjee S, Barrand G, Behner F, Bellagamba L, Boudreau J, Broglia L, Brunengo A, Burkhardt H, Chauvie S, Chuma J, Zschiesche D (2003) Geant4—a simulation toolkit. Nucl Instrum Methods Phys Res Sect A Accel Spectrom Detect Assoc Equip 506(3):250–303
Andreo P (1991) Monte Carlo techniques in medical radiation physics. Phys Med Biol 36:861–920
Antic V, Ciraj-Bjelac O, Stankovic J, Arandjic D, Todorovic N, Lucic S (2014) Radiation exposure to nuclear medicine staff involved in PET/CT practice in Serbia. Radiat Prot Dosimetry 162(4):577–585
Atomic Law (2019) Official Journal of 2019, item 1593
Batchelor S, Penfold A, Aric I, Huggins R (1991) Radiation dose to hands in nuclear medicine. Nucl Med Commun 12:439–444
Becker F, Blunck Ch (2011) Investigation of radiation exposure of medical staff: measurements supported by simulations with an articulated hand phantom. Radiat Meas 46:1299–1302
Becker F, Blunck C, Hegenbart L, Heide B, Leone D, Nagels S, Schimmelpfeng J (2008a) Modelling of hand phantoms and optimization of dose measurements in inhomogeneous beta-photon-radiation fields using the MCNP code, ICRP 12
Becker F, Blunck Ch, Hegenbart L, Heide B, Leone D, Nagels S, Schimmelpfeng J (2008b) Modelling of hand phantoms and optimisation of dose measurements in inhomogeneous beta-photon-radiation fields using the MCNP code. In: 12th international congress of the International Radiation Protection Association (IRPA), Buenos Aires, Argentina, October 2008
Becker F, Blunck Ch, Figueira C, Esteves B, Di Maria S, Paulo G, Santos J, Teles P, Vaz P (2011) Radiation exposure of medical staff: application of hand phantoms in experiments and simulations. Safety Engineering “First International Conference on Radiation and Dosimerty in Various Feilds of Research”, UDC 62-784.7 https://doi.org/10.7562/se2012.2.02.08
Becker F, Göpfert F, Figueira C, Blunck Ch (2014) Application of hand phantoms in simulations to determine the radiation exposure of medical Staff. Progr Nucl Sci Technol 4:891–895
Blunck C, Becker F, Hegenbart L, Heide B, Schimmelpfeng J, Urban M (2009) Radiation protection in inhomogeneous beta–gamma fields and modelling of hand phantoms with MCNPX. Radiat Prot Dosim 134:13–22
Blunck Ch, Becker F, Urban M (2011) Simulation of beta radiator handling procedures in nuclear medicine by means of a movable hand phantom. Radiat Prot Dosim 144:497–500
Carnicer A, Sans-Merce M, Baechler S, Barth I, Donadille L, Ferrari P, Fulop M, Ginjaume M, Gualdrini G, Krim S, Mariotti M, Ortega X, Rimpler A, Ruiz N, Vanhavere F (2011) Hand exposure in diagnostic nuclear medicine with 18F- and 99mTc-labelled radiopharmaceuticals—results of the ORAMED project. Radiat Meas 46:1277–1282
Chiesa C, De Sanctis V, Crippa F, Schiavini M, Fraigola CE, Bogni A, Pascali C, Decise D, Marchesini R, Bombardieri E (1997) Radiation dose to technicians per nuclear medicine procedure: comparison between technetium: 99m, gallium: 67 and iodine: 131 radiotracers and fluorine: 18 fluorodeoxyglucose. Eur J Nucl Med 24:1380–1389
COUNCIL DIRECTIVE 2013/59/EURATOM (2013) of 5 December 2013 laying down basic safety standards for protection against the dangers arising from exposure to ionising radiation, and repealing Directives 89/618/Euratom, 90/641/Euratom, 96/29/Euratom, 97/43/Euratom and 2003/122/Euratom
Covens P, Berus D, Buls N, Clerinx P, Vanhavere F (2007) Personal dose monitoring in hospitals: global assessment, critical applications and future needs. Radiat Prot Dosim 124:250–258
Dalianis K, Malamitsi J, Gogou L, Pagou M, Efthimiadou R, Andreou J, Louizï A, Georgiou E (2006) Dosimetric evaluation of the staff working in a PET/CT department. Nucl Inst Methods Phys Res A 569:548–550
Donadille L, Bouachri AE, Lahaye T, Trompier F, Wargnies JP (2005) Feasibility study of an activity extremity dosimetry prototype. Radiat Prot Dosim 115:548–552
European Pharmacopoeia (2017), 9th edn. (9.0–9.2.)
Figueira C, Becker F, Blunck C, DiMaria S, Baptista M, Esteves B, Paulo G, Santos J, Teles P, Vaz P (2013) Medical staff extremity dosimetry in CT fluoroscopy: an anthropomorphic hand voxel phantom study. Phys Med Biol 58:5433–5448
Gedliczka A (2001) Atlas of human measures. Centralny Instytut Ochrony Pracy CIOP, Warszawa
Hastings DL, Hilles PG, Jeans SP, Waller ML (1997) An assessment of finger doses received by staff while preparing and injecting radiopharmaceuticals. Nucl Med Commun 18:785–790
International Organization for Standardization (2019) Radiological protection—X and gamma reference radiation for calibrating dosimeters and dose rate meters and for determining their response as a function of photon energy—part 3: calibration of area and personal dosimeters and the measurement of their response as a function of energy and angle of incidence ISO 4037-3 Geneva, Switzerland
Jankowski J, Olszewski J, Kluska K (2002) Distribution of equivalent doses to skin of the hands of nuclear medicine personnel. Radiat Prot Dosim 106:177–180
Konefał A (2006) Monte Carlo simulations using GEANT4. Postępy Fizyki t. 57, ISSN: 0032-5430 (Polish), pp 242–251
Królicki L, Kunikowska J, Kobylecka M, Mączewska J, Fronczewska K (2011) Emission tomography (PET) in diagnosis of oncological diseases. Prog Med Sci 2:104–108
Kubo ALSL, Mauricio CLP (2014) TLD occupational dose distribution study in nuclear medicine. Radiat Meas 71:442–446
Lecchi M, Malaspina S, Del Sole A (2016) Effective and equivalent dose minimization for personnel in PET procedures: how far are we from the goal? Eur J Nucl Med Mol Imaging 43:2279–2282
Leide-Svegborn S (2010) Radiation exposure of patient and the personnel from a PET/CT procedure with 18F-FDG. Radiat Prot Dosim 139:208–213
Leide-Svegborn S (2011) External radiation exposure of personnel in nuclear medicine from 18F, 99mTc and 131I with special reference to fingers, eyes and thyroid. Radiat Prot Dosim 149:196–206
Martin CJ, Sutton DG (2015) Practical radiation protection in healthcare, 2nd edn. Oxford University Press, Oxford
Montgomery A, Anstee DE, Martin CJ, Hilditch TE (1999) Reductions in finger doses for radiopharmaceutical dispensing by a syringe shield and an automatic dose dispenser. Nucl Med Commun 20:189–194
Piciu D (2012) Nuclear Endocrinology. Springer, Berlin. https://doi.org/10.1007/978-3-642-25014-9
Sæther HK, Davidson TM, Widmark A, Wøhin T (2005) Measurements if finger doses in X-ray guided surgery, nuclear medicine and research. Radiat Prot Dosim 113:392–395
Sandouqa AS, Haddadin IM, Abu-Khaled YS (2011) Hand equivalent doses of nuclear medicine staff in Jordan: preliminary experimental studies. Radiat Meas 46:250–253
Sherbini S, Ilas D, Eckerman K, DeCicco J (2011) Correction factors applied to finger dosimetry: a theoretical assessment of appropriate values for use in handling radiopharmaceuticals. Health Phys 101:1–12
Smart R (2004) Task-specific monitoring of nuclear medicine technologists’ radiation exposure. Radiat Prot Dosim 109:201–209
Vanhavere F, Berus D, Buls N, Covens P (2006) The use of extremity dosemeters in a hospital environment. Radiat Prot Dosim 118:190–195
Vanhavere F, Carinou E, Gualdrini G, Clairand I, Sans Merce M, Ginjaume M, Nikodemova D, Jankowski J, Bordy J-M, Rimpler A, WachS, Martin P, Struelens L, Krim S, Koukorava C, Ferrari P, Mariotti F. Fantuzzi E, Donadille L, Itié C, Ruiz N, Carnicer A, Fulop M, Domienik J, Brodecki M, Daures J, Barth I, Bilski P (2012) Optimization of radiation protection of medical staff EURADOS Report 2012–02. Braunschweig
Wrzesień M (2018a) The effect of work system on the hand exposure of workers in 18F-FDG production centres. Australas Phys Eng Sci Med 41:541–548
Wrzesień M (2018b) Simplicity or complexity of the radiopharmaceutical production process in the light of optimization of radiation protection of staff—99mTc versus 18F. Med Pr 69(3):317–327
Wrzesień M, Albiniak Ł (2016) Hand exposure of workers in 18F-FDG production centre. J Radiol Prot 36:N67–N76
Wrzesień M, Napolska K (2015) Investigation of radiation protection of medical staff performing medical diagnostic examinations by using PET/CT technique. J Radiol Prot 35:197–207
Wrzesień M, Olszewski J (2011) Hand exposure of nuclear medicine workers during administration of radioiodine. Radiat Prot Dosim 151:147–152
Wrzesień M, Olszewski J (2018) Wrist dosimeter in nuclear medicine—an alternative for the ring dosimeter? Phys Med 54:117–120
Wrzesień M, Olszewski J, Jankowski J (2008) Hand exposure to ionizing radiation of nuclear medicine workers. Radiat Prot Dosim 130:325–330
Wrzesień M, Napolska K, Olszewski J (2016) Exposure of personnel and public due to using 153sm-labelled EDTMP–QUADRAMET® in nuclear medicine procedures. Radiat Prot Dosim 168:396–400
Wrzesień M, Albiniak Ł, Biegała M (2018) The structure of Hp(0.07) values obtained by the nuclear medicine personnel during 18F-FDG production and injection. Radiat Prot Dosim 184:224–229
Acknowledgements
This research was financially supported by the Ministry of Science and Higher Education of Poland, project number B 1411500000542.02 and B 1611500001135.02.
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Albiniak, Ł., Wrzesień, M. Using Monte Carlo methods for Hp(0.07) values assessment during the handling of 18F-FDG. Radiat Environ Biophys 59, 643–650 (2020). https://doi.org/10.1007/s00411-020-00864-9
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DOI: https://doi.org/10.1007/s00411-020-00864-9