Radiation and Environmental Biophysics

, Volume 48, Issue 2, pp 169–179 | Cite as

Screening effects in risk studies of thyroid cancer after the Chernobyl accident

  • Jan Christian Kaiser
  • P. Jacob
  • M. Blettner
  • S. Vavilov
Original Paper

Abstract

In this article scenarios have been developed, which simulate screening effects in ecological and cohort studies of thyroid cancer incidence among Ukrainians, whose thyroids have been exposed to 131I in the aftermath of the Chernobyl accident. If possible, the scenarios were based on directly observed data, such as the population size, dose distributions and thyroid cancer cases. Two scenarios were considered where the screening effect on baseline cases is either equal to or larger than that of radiation-related thyroid cancer cases. For ecological studies in settlements with more than ten measurements of the 131I activity in the human thyroid in May–June 1986, the screening bias appeared small (<19%) for all risk quantities. In the cohort studies, the excess absolute risk per dose was larger by a factor of 4 than in the general population. For an equal screening effect on baseline and radiation-related cancer (Scenario 1) the excess relative risk was about the same as in the general population. However, a differential screening effect (Scenario 2) produced a risk smaller by a factor of 2.5. A comparison with first results of the Ukrainian–US-American cohort study did not give any indication that a differential screening effect has a marked influence on the risk estimates. The differences in the risk estimates from ecological studies and cohort studies were explained by the different screening patterns in the general population and in the much smaller cohort. The present investigations are characterized by dose estimates for many settlements which are very weakly correlated with screening, the confounding variable. The results show that under these conditions ecological studies may provide risk estimates with an acceptable bias.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jan Christian Kaiser
    • 1
  • P. Jacob
    • 1
  • M. Blettner
    • 2
  • S. Vavilov
    • 3
  1. 1.Helmholtz-Zentrum München, German Research Centre for Environmental HealthInstitute of Radiation ProtectionNeuherbergGermany
  2. 2.Institut für Medizinische BiometrieEpidemiologie und Informatik Johannes Gutenberg-Universität MainzMainzGermany
  3. 3.Radiation Protection InstituteAcademy of Technological SciencesKievUkraine

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