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SIRT1 as a Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease

  • REVIEW: ROLE OF SIRT1 in COPD
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Abstract

Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by irreversible airflow obstruction and lung function decline. It is well established that COPD represents a major cause of morbidity and mortality globally. Due to the substantial economic and social burdens associated with COPD, it is necessary to discover new targets and develop novel beneficial therapies. Although the pathogenesis of COPD is complex and remains to be robustly elucidated, numerous studies have shown that oxidative stress, inflammatory responses, cell apoptosis, autophagy, and aging are involved in the pathogenesis of COPD. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase belonging to the silent information regulator 2 (Sir2) family. Multiple studies have indicated that SIRT1 plays an important role in oxidative stress, apoptosis, inflammation, autophagy, and cellular senescence, which contributes to the pathogenesis and development of COPD. This review aimed to discuss the functions and mechanisms of SIRT1 in the progression of COPD and concluded that SIRT1 activation might be a potential therapeutic strategy for COPD.

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Acknowledgements

The authors would like to thank all the reviewers who participated in the review, MJEditor (www.mjeditor.com) for providing English editing services during the preparation of this manuscript, and BioRender (BioRender.com) for the Figure 1.

Funding

This work was supported by the National Natural Science Foundation of China [81500036]; Scientific Research Fund of Hunan Provincial Education Department [21B0005]; Hunan Provincial Natural Science Foundation [2022JJ30917]; Undergraduate Education and Teaching Reform Project of Central South University [2021JGB061]; and Postgraduate Education and Teaching Reform Project of Central South University [2021jy156].

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Authors and Affiliations

  1. Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China

    Siqi Li, Qiong Huang & Baimei He

  2. Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China

    Siqi Li, Qiong Huang & Baimei He

  3. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China

    Siqi Li, Qiong Huang & Baimei He

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  1. Siqi Li
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SL contributed to writing of the original draft preparation. QH contributed to writing, reviewing, and editing of the manuscript. BH contributed to supervision and writing, reviewing, and editing of the manuscript.

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Correspondence to Baimei He.

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Li, S., Huang, Q. & He, B. SIRT1 as a Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease. Lung 201, 201–215 (2023). https://doi.org/10.1007/s00408-023-00607-9

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