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Association Analysis of Interleukin-17 Gene Polymorphisms with the Risk Susceptibility to Tuberculosis

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Abstract

Background

Recently, many institutions have investigated the associations of interleukin-17 (IL17) polymorphisms with tuberculosis (TB) susceptibility, while those results are inconsistent. The purpose of this meta-analysis is to comprehensively assess whether IL17A rs22275913, IL17F rs763780, and IL17A rs3748067 polymorphisms are correlated with TB risk.

Methods

Electronic bibliographic databases were searched for case–control studies which potentially focused on the relationship between the aforementioned polymorphisms and TB risk on October 15th, 2015. Pooled odds ratios (OR) combined with 95 % confidence intervals (CI) were employed to assess the associations.

Results

There was no significant association of IL-17A rs22275913 polymorphism with susceptibility to TB in Asians or Caucasians. For IL-17A rs3748067 polymorphism, significant associations were observed in Asian (T vs. C: OR 1.461, 95 % CI 1.158–1.844, P = 0.001; TT vs. CC: OR 1.871, 95 % CI 1.140–3.069, P = 0.013; TT/TC vs. CC: OR 1.392 95 % CI 1.062–1.825, P = 0.017; TT vs. TC/CC: OR 1.820, 95 % CI 1.111–2.981, P = 0.017). For IL-17F rs763780, we detected the significant associations under allele contrast, heterozygote, dominant and recessive models (C vs. T: OR 1.571, 95 % CI 1.352–1.824, P = 0.000; CT vs. TT: OR 1.624, 95 % CI 1.346–1.958, P = 0.000; CT/TT vs. TT: OR 1.639, 95 % CI 1.381–1.946, P = 0.000, respectively). The corresponding results were also detected in Asian populations (C vs. T: OR 1.068, 95 % CI 1.380–1.875, P = 0.000; CT vs. TT: OR 1.689, 95 % CI 1.390–2.053, P = 0.000; CT/TT vs. TT: OR 1.695, 95 % CI 1.420–2.023, P = 0.000), while there were no significant associations in Caucasian.

Conclusion

IL-17F rs763780 allele C and IL-17A rs3748067 allele C may be involved in the susceptibility to TB in Asian populations. There were no significant associations between IL-17A rs22275913 polymorphism and risk of TB.

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References

  1. Yuen CM, Weyenga HO, Kim AA, Malika T, Muttai H, Katana A, Nganga L, Cain KP, De Cock KM (2014) Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV–Kenya, 1998–2012. PLoS One 9(6):e99880. doi:10.1371/journal.pone.0099880

    Article  PubMed  PubMed Central  Google Scholar 

  2. World Health Organization (2014) WHO Global Tuberculosis Report 2014

  3. Flynn JL (2004) Immunology of tuberculosis and implications in vaccine development. Tuberculosis (Edinb) 84(1–2):93–101

    Article  Google Scholar 

  4. Ma E, Ren L, Wang W, Takahashi H, Wagatsuma Y, Ren Y, Gao F, Bi L (2015) Demographic and socioeconomic disparity in knowledge about tuberculosis in Inner Mongolia, China. J Epidemiol 25(4):312–320. doi:10.2188/jea.JE20140033

    Article  PubMed  PubMed Central  Google Scholar 

  5. Tomás BA, Pell C, Cavanillas AB, Solvas JG, Pool R, Roura M (2013) Tuberculosis in migrant populations. A systematic review of the qualitative literature. PLoS One 8(12):e82440. doi:10.1371/journal.pone.0082440

    Article  Google Scholar 

  6. Nadjane Batista Lacerda S, de Abreu Cristina, Temoteo R, Monteiro Maria Ribeiro, de Figueiredo T, Tavares Darliane, de Luna F, Nunes Alves, de Sousa M, Carlos de Abreu L, Luiz Affonso Fonseca F (2014) Individual and social vulnerabilities upon acquiring tuberculosis: a literature systematic review. Int Arch Med 7:35. doi:10.1186/1755-7682-7-35

    Article  PubMed  PubMed Central  Google Scholar 

  7. Dou HY, Chen YY, Kou SC, Su IJ (2015) Prevalence of Mycobacterium tuberculosis strain genotypes in Taiwan reveals a close link to ethnic and population migration. J Formos Med Assoc 114(6):484–488. doi:10.1016/j.jfma.2014.07.006

    Article  PubMed  Google Scholar 

  8. Tong X, Chen L, Liu S, Yan Z, Peng S, Zhang Y, Fan H (2015) Polymorphisms in HLA-DRB1 gene and the risk of tuberculosis: a meta-analysis of 31 studies. Lung 193(2):309–318. doi:10.1007/s00408-015-9692-z

    Article  CAS  PubMed  Google Scholar 

  9. Huang QP, Liao N, Zhao H, Chen ML, Xie ZF (2015) Lack of association between the IL1B (−511 and +3954), IL1RN VNTR polymorphisms and tuberculosis risk: a Meta-analysis. Lung. doi:10.1007/s00408-015-9796-5

    Google Scholar 

  10. Li CP, Zhou Y, Xiang X, He M (2015) Relationship of HLA-DRB1 gene polymorphism with susceptibility to pulmonary tuberculosis: updated meta-analysis. Int J Tuberc Lung Dis 19(7):841–849. doi:10.5588/ijtld.14.0521

    Article  PubMed  Google Scholar 

  11. Curtis J, Luo Y, Zenner HL, Cuchet-Lourenco D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nurnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S (2015) Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet 47(5):523–527. doi:10.1038/ng.3248

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ridruechai C, Mahasirimongkol S, Phromjai J, Yanai H, Nishida N, Matsushita I, Ohashi J, Yamada N, Moolphate S, Summanapan S, Chuchottaworn C, Manosuthi W, Kantipong P, Kanitvittaya S, Sawanpanyalert P, Keicho N, Khusmith S, Tokunaga K (2010) Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. Genes Immun 11(5):416–422. doi:10.1038/gene.2010.26

    Article  CAS  PubMed  Google Scholar 

  13. Xu C, Tang P, Ding C, Li C, Chen J, Xu Z, Mao Y, Wu M, Zhao J (2015) Vitamin D receptor gene FOKI polymorphism contributes to increasing the risk of HIV-negative tuberculosis: evidence from a meta-analysis. PLoS One 10(10):e0140634. doi:10.1371/journal.pone.0140634

    Article  PubMed  PubMed Central  Google Scholar 

  14. Wu L, Deng H, Zheng Y, Mansjo M, Zheng X, Hu Y, Xu B (2015) An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population. Int J Infect Dis 38:129–135. doi:10.1016/j.ijid.2015.08.003

    Article  CAS  PubMed  Google Scholar 

  15. Lee YH, Song GG (2015) Associations between tumor necrosis factor-alpha polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis. Genet Mol Res 14(3):8602–8612. doi:10.4238/2015.July.31.8

    Article  CAS  PubMed  Google Scholar 

  16. Shi GC, Zhang LG (2015) Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis. Genet Mol Res 14(3):8526–8531. doi:10.4238/2015.July.28.22

    Article  CAS  PubMed  Google Scholar 

  17. Abhimanyu Bose M, Komal Varma-Basil M (2013) Lack of association between IL17A and IL17F polymorphisms and related serum levels in north Indians with tuberculosis. Gene 529(1):195–198. doi:10.1016/j.gene.2013.06.090

    Article  CAS  PubMed  Google Scholar 

  18. Ocejo-Vinyals JG, de Mateo EP, Hoz MA, Arroyo JL, Aguero R, Ausin F, Farinas MC (2013) The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain. Cytokine 64(1):58–61. doi:10.1016/j.cyto.2013.05.022

    Article  CAS  PubMed  Google Scholar 

  19. Peng R, Yue J, Han M, Zhao Y, Liu L, Liang L (2013) The IL-17F sequence variant is associated with susceptibility to tuberculosis. Gene 515(1):229–232. doi:10.1016/j.gene.2012.11.017

    Article  CAS  PubMed  Google Scholar 

  20. Bulat-Kardum LJ, Etokebe GE, Lederer P, Balen S, Dembic Z (2015) Genetic polymorphisms in the toll-like receptor 10, interleukin (IL)17A and IL17F genes differently affect the risk for tuberculosis in Croatian population. Scand J Immunol 82(1):63–69. doi:10.1111/sji.12300

    Article  CAS  PubMed  Google Scholar 

  21. Du J, Han J, Li X, Zhang Y, Li H, Yang S (2015) StIL-17 gene polymorphisms in the development of pulmonary tuberculosis. Int J Clin Exp Pathol 8(3):3225–3229

    PubMed  PubMed Central  Google Scholar 

  22. Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603–605. doi:10.1007/s10654-010-9491-z

    Article  PubMed  Google Scholar 

  23. Zou W, Restifo NP (2010) T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol 10(4):248–256. doi:10.1038/nri2742

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Curtis MM, Way SS (2009) Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 126(2):177–185. doi:10.1111/j.1365-2567.2008.03017.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Ye P, Garvey PB, Zhang P, Nelson S, Bagby G, Summer WR, Schwarzenberger P, Shellito JE, Kolls JK (2001) Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol 25(3):335–340. doi:10.1165/ajrcmb.25.3.4424

    Article  CAS  PubMed  Google Scholar 

  26. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM (2007) IL-23 and IL-17 in the establishment of protective pulmonary CD4+T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8(4):369–377. doi:10.1038/ni1449

    Article  CAS  PubMed  Google Scholar 

  27. Peng M, Wang Z, Yao C, Jiang L, Jin Q, Wang J, Li B (2008) Interleukin 17-producing [gamma][delta] T cells increased in patients with active pulmonary tuberculosis. Cell Mol Immunol 5(3):203–208

    Article  PubMed  PubMed Central  Google Scholar 

  28. Isaakidis P, Casas EC, Das M, Tseretopoulou X, Ntzani EE, Ford N (2015) Treatment outcomes for HIV and MDR-TB co-infected adults and children: systematic review and meta-analysis. Int J Tuberc Lung Dis 19(8):969–978. doi:10.5588/ijtld.15.0123

    Article  CAS  PubMed  Google Scholar 

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    Authors and Affiliations

    1. Department of Orthopaedics, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, People’s Republic of China

      Jian Zhao & Ming Li

    2. Department of Anesthesiology, Affiliated Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China

      Cen Wen

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    1. Jian Zhao
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    Correspondence to Ming Li.

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    Jian Zhao and Cen Wen have contributed equally to this work.

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    Zhao, J., Wen, C. & Li, M. Association Analysis of Interleukin-17 Gene Polymorphisms with the Risk Susceptibility to Tuberculosis. Lung 194, 459–467 (2016). https://doi.org/10.1007/s00408-016-9860-9

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