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Polymorphisms in HLA-DRB1 Gene and the Risk of Tuberculosis: A Meta-analysis of 31 Studies

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Abstract

Purpose

The HLA-DRB1 gene polymorphisms have been implicated in susceptibility to tuberculosis (TB). However, a large number of studies have reported inconclusive results. This study was conducted to investigate the relationship of HLA-DRB1 gene polymorphisms and TB risk by a meta-analysis.

Methods

A search was performed in Embase, PubMed, Wanfang Database, and China National Knowledge Internet (CNKI) up to Jul 30, 2014. Odds ratio (OR) and 95 % confidence interval (95 % CI) were used to assess the association. Statistical analyses were calculated by STATA 11.0 software.

Results

All 31 articles involving 3,416 cases and 4,515 controls were identified. The pooled results indicated a significant association between HLA-DRB1*04 (OR 1.22, 95 % CI 1.00–1.48, P = 0.048), *09 (OR 1.50, 95 % CI 1.08–2.08, P = 0.016), *10 (OR 1.23, 95 % CI 1.01–1.49, P = 0.035), *11 (OR 0.72, 95 % CI 0.53–0.99, P = 0.044), *15 (OR 1.40, 95 % CI 1.14–1.73, P = 0.001), and *16 (OR 1.33, 95 % CI 1.08–1.63, P = 0.007) gene polymorphisms and TB risk. In addition, the results also show no significant association between HLA-DRB1*01 (P = 0.748), *03 (P = 0.947), *07 (P = 0.966), *08 (P = 0.440), *12 (P = 0.288), *13 (P = 0.241), and *14 (P = 0.551) gene polymorphisms and TB risk.

Conclusions

This study suggested that the HLA-DRB1*04, *09, *10, *15, and *16 gene polymorphisms may contribute to the risk of TB, especially in the East Asian. But the HLA-DRB1*11 gene polymorphism may be a protective factor for TB risk. Unfortunately, there is no significant association between the HLA-DRB1*01, *03, *07, *08, *12, *13, and *14 gene polymorphisms and TB risk.

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Acknowledgments

This work was supported by Science and Technology Bureau of Sichuan Province Grant (2012JY0013).

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China

    Xiang Tong, Sitong Liu, Zhipeng Yan, Shifeng Peng & Hong Fan

  2. West China Hospital/West China Medical School, Sichuan University, Chengdu, 610041, Sichuan, China

    Lingmin Chen

  3. The Periodical Press of West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China

    Yonggang Zhang

Authors
  1. Xiang Tong
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  2. Lingmin Chen
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  3. Sitong Liu
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  4. Zhipeng Yan
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  6. Yonggang Zhang
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  7. Hong Fan
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Correspondence to Yonggang Zhang or Hong Fan.

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Tong, X., Chen, L., Liu, S. et al. Polymorphisms in HLA-DRB1 Gene and the Risk of Tuberculosis: A Meta-analysis of 31 Studies. Lung 193, 309–318 (2015). https://doi.org/10.1007/s00408-015-9692-z

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  • DOI: https://doi.org/10.1007/s00408-015-9692-z

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