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RETRACTED ARTICLE: ATF3 and Extracellular Matrix-Related Genes Associated with the Process of Chronic Obstructive Pulmonary

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This article was retracted on 17 August 2015

Abstract

Introduction

Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide and is proved to be the number three cause of death in globally. The objective of this study was to explore the molecular mechanism of the progression of COPD.

Methods

Using the GSE1650 affymetrix microarray data accessible from Gene Expression Omnibus database, we first identified the differentially expressed genes (DEGs) between 18 COPD samples and 12 normal samples, followed by the GO / KEGG pathway analysis and gene interaction networks analysis of the DEGs. Our study identified 134 DEGs which involved in regulation of immune response, vesicle transport system, growth regulator and extracellular matrix (ECM)-related pathways.

Results

Gene interaction networks analysis showed that the sub-network involved by activating transcription factor-3 (ATF3) was the most significant sub-network in gene interaction networks. Furthermore, the investigation of extracellular matrix-related genes showed that genes like collagen and insulin-like growth factor binding protein could clearly distinguish the COPD and normal control.

Conclusions

The genes regulated by ATF3 transcriptional activator as well as ECM-related genes may play an important role in the process of COPD. Our study provides a comprehensive bioinformatics analysis of genes and pathways which may be involved in the progression of COPD.

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Acknowledgments

We wish to express our warm thanks to all the authors who contributed to the research.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Nanjing Command, PLA, 156 Xihuan Bei Road, Fuzhou, 350025, China

    Jia Ye, De-Ling Liu & Guo-xiang Lai

  2. Department of Anesthesiology, The People’s Hospital of Fujian Province, Fujian University of Traditional Chinese Medicine, Fuzhou, 350004, China

    Li Wen

Authors
  1. Jia Ye
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  2. Li Wen
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  4. Guo-xiang Lai
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Corresponding author

Correspondence to Guo-xiang Lai.

Additional information

Jia Ye and Li Wen should be regarded as co-first authors.

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Ye, J., Wen, L., Liu, DL. et al. RETRACTED ARTICLE: ATF3 and Extracellular Matrix-Related Genes Associated with the Process of Chronic Obstructive Pulmonary. Lung 192, 881–888 (2014). https://doi.org/10.1007/s00408-014-9631-4

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  • DOI: https://doi.org/10.1007/s00408-014-9631-4

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