Abstract
Asthma and atopy have a complex background that may result from the interaction of genes and the environment. Interleukin (IL)-10 is known to play various roles in immune-regulating and anti-inflammatory responses. The aim of this study was to evaluate the possible effect of the IL-10 promoter polymorphisms on susceptibility to childhood asthma. We recruited 333 patients with atopic asthma, 55 with nonatopic asthma, and 248 normal controls. We performed a genetic association study of three genetic polymorphisms (IL-10 –1082A>G, IL-10 –819T>C, and IL-10 –592A>C) of the IL-10 promoter. There was no difference between atopic asthma, nonatopic asthma, and normal controls with respect to allele, genotype, or haplotype frequencies of these IL-10 polymorphisms. However, the −1082A>G polymorphism and ATA haplotype in the IL-10 promoter gene were associated with airway hyper responsiveness (AHR) and the –819T>C, –592A>C, and ATA and ACC haplotypes were also shown to be related to serum eosinophil cationic protein (ECP). Our results suggest that the polymorphisms within the IL-10 promoter may have a disease-modifying effect in the asthmatic airway.
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Acknowledgments
This study was supported by a faculty research grant from Yonsei University College of Medicine for 2010 (6-2010-0064), and the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2009-0075056 and 2011-0001173).
Disclosure
K. W. Kim, Y.-J. Lee, J. Baek, M. H. Sohn, and K.-E. Kim have no conflicts of interests or financial ties to disclose.
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Kim, K.W., Lee, K.E., Hong, J.Y. et al. Involvement of IL-10 Gene Promoter Polymorphisms in the Susceptibility for Childhood Asthma. Lung 189, 417–423 (2011). https://doi.org/10.1007/s00408-011-9312-5
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DOI: https://doi.org/10.1007/s00408-011-9312-5