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Case–control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics

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Abstract

The aim of this study is to investigate possible associations between a set of single-nucleotide polymorphisms (SNPs) within 10 genes with Schizophrenia (SCZ) and response to antipsychotics in Korean in-patients treated with antipsychotics. Two hundred and twenty-one SCZ in-patients and 170 psychiatrically healthy controls were genotyped for 42 SNPs within ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. Rs10042486 within 5HTR1A was associated with both SCZ and clinical improvement on PANSS total scores as well as on PANSS positive and PANSS negative scores. The haplotype analyses focusing on the four, three and two blocks’ haplotypes within 5HTR1A confirmed such findings as well. We did not observe any significant association between the remaining genetic variants under investigation in this study and clinical outcomes. Our preliminary findings suggest that rs10042486 within 5HTR1A promoter region could be associated with SCZ and with clinical improvement on PANSS total, positive and negative scores in Korean patients with SCZ. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

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Acknowledgments

This work was supported by the Institute of Clinical Medicine Research of Bucheon St. Mary’s Hospital, Research Fund, 2011.

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Authors and Affiliations

  1. Department of Biomorphology and Biotechnologies, Division of Biology and Genetics, University of Messina, Messina, Italy

    Concetta Crisafulli

  2. Institute of Psychiatry, University of Bologna, Bologna, Italy

    Alberto Chiesa, Beatrice Balzarro, Costanza Andrisano & Alessandro Serretti

  3. Department of Psychiatry, College of Medicine, Korea University, Ansan, Kyounggi-Do, Republic of Korea

    Changsu Han

  4. Department of Psychiatry, Bucheon St. Mary’s Hospital, The Catholic University of Korea College of Medicine, 2 Sosa-Dong, Wonmi-Gu, Bucheon, Kyounggi-Do, 420-717, Republic of Korea

    Soo-Jung Lee & Chi-Un Pae

  5. Department of Neurology, College of Medicine, Korea University, Ansan, Kyounggi-Do, Republic of Korea

    Moon Ho Park

  6. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA

    Ashwin A. Patkar & Chi-Un Pae

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  1. Concetta Crisafulli
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  2. Alberto Chiesa
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Correspondence to Chi-Un Pae.

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Crisafulli, C., Chiesa, A., Han, C. et al. Case–control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics. Eur Arch Psychiatry Clin Neurosci 262, 199–205 (2012). https://doi.org/10.1007/s00406-011-0278-3

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  • DOI: https://doi.org/10.1007/s00406-011-0278-3

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