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The impact of tamoxifen treatment on voice parameters in premenopausal women with breast cancer

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Abstract

Objective

The study aims to investigate the estrogen-agonistic effects of tamoxifen on voice parameters in premenopausal women diagnosed with breast cancer.

Methods

A total of 108 premenopausal women were included, segmented into distinct treatment groups and a control group. Objective sound analysis was conducted using robust statistical methods, employing SPSS 25.0 for data analysis.

Results

The study identified a statistically significant reduction in Jitter values across all treatment groups compared to the control group. No significant changes were observed in other voice quality parameters such as F0, Shimmer, NHR, and HNR.

Conclusions

The findings suggest that tamoxifen may have an estrogen-agonistic effect on voice quality, thereby potentially influencing future treatment protocols. This research fills a critical void in existing literature and sets the stage for more comprehensive studies that consider affects of hormonal therapies to voice.

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Data availability

Data available on request from the authors.

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Funding

None declared.

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Authors and Affiliations

  1. Department of Medical Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana, Turkey

    Serdar Ata, Mahmut Büyükşimşek, Timuçin Çil & Berna Bozkurt Duman

  2. Department of Otorhinolaryngology, Adana City Training and Research Hospital, University of Health Sciences, Adana, Turkey

    Nur Yücel Ekici

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  1. Serdar Ata
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  2. Nur Yücel Ekici
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Correspondence to Serdar Ata.

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The authors declare no conflict of interest.

Ethical approval

The protocol of this prospective study was approved by the Health Sciences University Adana City Training and Research Hospital Clinical Research Ethics Committee (Approval No./Date: 2634/2023).

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Ata, S., Ekici, N.Y., Büyükşimşek, M. et al. The impact of tamoxifen treatment on voice parameters in premenopausal women with breast cancer. Eur Arch Otorhinolaryngol 281, 1025–1030 (2024). https://doi.org/10.1007/s00405-023-08328-8

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  • DOI: https://doi.org/10.1007/s00405-023-08328-8

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