Skip to main content
SpringerLink
Log in

Diagnostic significance of peripheral blood indices for eosinophilic chronic rhinosinusitis in Chinese adults

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objective

Eosinophilic chronic rhinosinusitis (eCRS) is a refractory subtype of CRS. This study aimed to compare the differences in clinical features and peripheral blood indices between eCRS and non-eCRS Chinese patients and identify the predictive factors for eCRS.

Methods

In this study, a total of 1352 patients with CRS were enrolled and divided into eCRS and non-eCRS groups based on the degree of eosinophilic infiltration in histopathology, and their demographic and clinical characteristics, as well as peripheral blood indices, were compared. Logistic regression analysis was used to identify the factors associated with eCRS, and the optimal cut-off values of predictors were determined using subject working curves.

Results

As compared to those in the non-eCRS group patients, the proportion of males, age, proportion of smokers, peripheral blood eosinophil count, and erythrocyte count were significantly higher, while the peripheral blood neutrophil count, platelet count, neutrophil/lymphocyte count ratio (NLR), platelet/lymphocyte count ratio (PLR), and neutrophil × platelet/lymphocyte count ratio (SII index) were significantly lower in the eCRS group patients. Logistic regression analysis showed that age, peripheral blood neutrophil count, eosinophil count, and platelet count were independent predictors of eCRS, and eosinophil count > 2.05 × 108/L could be used as a diagnostic marker for eCRS with a sensitivity and specificity of 87.1% and 78.3%, respectively.

Conclusions

There were significant differences in the clinical features of eCRS and non-eCRS patients. Peripheral blood eosinophil count could early and more accurately predict eCRS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Data availability

The data are available from the corresponding author on reasonable request.

References

  1. Fokkens WJ, Lund VJ, Hopkins C et al (2020) European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 58(Suppl S29):1–464. https://doi.org/10.4193/Rhin20.600

    Article  PubMed  Google Scholar 

  2. Hong SJ, Lee JK, Lee HS et al (2014) Availability of preoperative systemic steroids on endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis. Yonsei Med J 55(6):1683–1690. https://doi.org/10.3349/ymj.2014.55.6.1683

    Article  PubMed  PubMed Central  Google Scholar 

  3. Brescia G, Barion U, Zanotti C et al (2017) The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis. Int Forum Allergy Rhinol 7(3):261–267. https://doi.org/10.1002/alr.21885

    Article  PubMed  Google Scholar 

  4. Zhang Z, Li G, Yu L et al (2023) Causal relationships between potential risk factors and chronic rhinosinusitis: a bidirectional two-sample Mendelian randomization study. Eur Arch Otorhinolaryngol 280(6):2785–2793. https://doi.org/10.1007/s00405-022-07798-6

    Article  PubMed  Google Scholar 

  5. Orlandi RR, Kingdom TT, Smith TL et al (2021) International consensus statement on allergy and rhinology: rhinosinusitis 2021. Int Forum Allergy Rhinol 11(3):213–739. https://doi.org/10.1002/alr.22741

    Article  PubMed  Google Scholar 

  6. Kim DH, Kim SW, Basurrah MA et al (2022) Clinical and laboratory features of various criteria of eosinophilic chronic rhinosinusitis: a systematic review and meta-analysis. Clin Exp Otorhinolaryngol 15(3):230–246. https://doi.org/10.21053/ceo.2022.00052

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Christensen DN, Franks ZG, McCrary HC et al (2018) A systematic review of the association between cigarette smoke exposure and chronic rhinosinusitis. Otolaryngol Head Neck Surg 158(5):801–816. https://doi.org/10.1177/0194599818757697

    Article  PubMed  Google Scholar 

  8. Sedaghat AR, Kuan EC, Scadding GK (2022) Epidemiology of chronic rhinosinusitis: prevalence and risk factors. J Allergy Clin Immunol Pract 10(6):1395–1403. https://doi.org/10.1016/j.jaip.2022.01.016

    Article  PubMed  Google Scholar 

  9. Krzeski A, Galewicz A, Chmielewski R et al (2011) Influence of cigarette smoking on endoscopic sinus surgery long-term outcomes. Rhinology 49(5):577–582. https://doi.org/10.4193/Rhino.10.038

    Article  PubMed  Google Scholar 

  10. Fujieda S, Imoto Y, Kato Y et al (2019) Eosinophilic chronic rhinosinusitis. Allergol Int 68(4):403–412. https://doi.org/10.1016/j.alit.2019.07.002

    Article  CAS  PubMed  Google Scholar 

  11. Zhang N, Van Zele T, Perez-Novo C et al (2008) Different types of t-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol 122(5):961–968. https://doi.org/10.1016/j.jaci.2008.07.008

    Article  CAS  PubMed  Google Scholar 

  12. Sivrice ME, Okur E, Yasan H et al (2020) Can the systemic immune inflammation index preoperatively predict nasal polyp subtypes? Eur Arch Otorhinolaryngol 277(11):3045–3050. https://doi.org/10.1007/s00405-020-06174-6

    Article  PubMed  Google Scholar 

  13. Delemarre T, Holtappels G, De Ruyck N et al (2021) A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 147(1):179-188.e172. https://doi.org/10.1016/j.jaci.2020.08.036

    Article  CAS  PubMed  Google Scholar 

  14. Stone RM, Gilliland DG, Klion AD (2004) Platelet-derived growth factor receptor inhibition to treat idiopathic hypereosinophilic syndrome. Semin Oncol 31(2 Suppl 6):12–17. https://doi.org/10.1053/j.seminoncol.2004.03.035

    Article  CAS  PubMed  Google Scholar 

  15. Takabayashi T, Schleimer RP (2020) Formation of nasal polyps: the roles of innate type 2 inflammation and deposition of fibrin. J Allergy Clin Immunol 145(3):740–750. https://doi.org/10.1016/j.jaci.2020.01.027

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Shimizu S, Ogawa T, Takezawa K et al (2015) Tissue factor and tissue factor pathway inhibitor in nasal mucosa and nasal secretions of chronic rhinosinusitis with nasal polyp. Am J Rhinol Allergy 29(4):235–242. https://doi.org/10.2500/ajra.2015.29.4183

    Article  PubMed  Google Scholar 

  17. Rha MS, Jeong Y, Kim J et al (2022) Is obstructive sleep apnea associated with erythrocytosis? A systematic review and meta-analysis. Laryngoscope Investig Otolaryngol 7(2):627–635. https://doi.org/10.1002/lio2.751

    Article  PubMed  PubMed Central  Google Scholar 

  18. Wojan F, Stray-Gundersen S, Nagel MJ et al (1985) (2021) Short exposure to intermittent hypoxia increases erythropoietin levels in healthy individuals. J Appl Physiol 130(6):1955–1960. https://doi.org/10.1152/japplphysiol.00941.2020

    Article  Google Scholar 

  19. Grayson JW, Li W, Ho J et al (2020) Topography of polyp recurrence in eosinophilic chronic rhinosinusitis. Int Forum Allergy Rhinol 10(5):604–609. https://doi.org/10.1002/alr.22529

    Article  PubMed  Google Scholar 

  20. Wang X, Meng Y, Lou H et al (2021) Blood eosinophil count combined with asthma history could predict chronic rhinosinusitis with nasal polyp recurrence. Acta Otolaryngol 141(3):279–285. https://doi.org/10.1080/00016489.2020.1844288

    Article  CAS  PubMed  Google Scholar 

  21. Zhong B, Yuan T, Du J et al (2021) The role of preoperative blood eosinophil counts in distinguishing chronic rhinosinusitis with nasal polyps phenotypes. Int Forum Allergy Rhinol 11(1):16–23. https://doi.org/10.1002/alr.22636

    Article  PubMed  Google Scholar 

  22. Ikeda K, Shiozawa A, Ono N et al (2013) Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil. Laryngoscope 123(11):E1-9. https://doi.org/10.1002/lary.24154

    Article  CAS  PubMed  Google Scholar 

  23. Hu Y, Cao PP, Liang GT et al (2012) Diagnostic significance of blood eosinophil count in eosinophilic chronic rhinosinusitis with nasal polyps in Chinese adults. Laryngoscope 122(3):498–503. https://doi.org/10.1002/lary.22507

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank all the reviewers who participated in the review and MJEditor (www.mjeditor.com) for its linguistic assistance during the preparation of this manuscript.

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by grants from the National Natural Science Foundation of China (81770978), Medicine and Health Science Technology Development Program of Shandong Province (202207010780), Qingdao Natural Science Foundation (23-2-1-199-zyyd-jch), Medicine and Health Science Technology Development Program of Qingdao (2021-WJZD175).

Author information

Author notes

  1. Shunke Li and Zengxiao Zhang have contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Qingdao University, No. 59, Haier Road, Laoshan District, Qingdao, 266003, China

    Shunke Li, Zengxiao Zhang, Lin Wang, Xudong Yan, Yan Jiang & Longgang Yu

Authors
  1. Shunke Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zengxiao Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lin Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xudong Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yan Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Longgang Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yan Jiang or Longgang Yu.

Ethics declarations

Conflict of interest

The authors declare that there is no conflict of interest.

Ethical approval

This study was approved by the Medical Ethics Committee of the Affiliated Hospital of Qingdao University.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, S., Zhang, Z., Wang, L. et al. Diagnostic significance of peripheral blood indices for eosinophilic chronic rhinosinusitis in Chinese adults. Eur Arch Otorhinolaryngol 281, 1337–1345 (2024). https://doi.org/10.1007/s00405-023-08324-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-023-08324-y

Keywords

Search

Navigation