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Matrix metalloproteinase 7 is associated with clinical and pathological characteristics of salivary adenoid cystic carcinomas

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Abstract

Objectives

The aim of this study was to investigate the relationship between matrix metalloproteinase-7 (MMP-7) expression and the clinical and pathological characteristics of salivary adenoid cystic carcinomas (SACC) of the palatal minor salivary gland.

Methods

In this study, 58 samples of SACC and 10 samples of normal salivary gland tissue were examined. Immunohistochemistry was used to detect MMP-7 and vascular endothelial growth factor A (VEGF-A) expression in SACC and normal tissues. The clinical and pathological characteristics of the patients with SACC were collected.

Results

Of the 58 SACC samples, 44 were positive for MMP-7, and the expression rate was 75.9%. No expression was detected in the 10 normal salivary gland tissues. The level of MMP-7 expression in the SACC and normal samples was significantly different. The level of expression of MMP-7 in the SACC samples did not correlate with age, sex or pathological type but did correlate with pathological grade, nerve infiltration and clinical stage. There was a positive correlation between VEGF-A and MMP-7 expression.

Conclusions

The SACC samples showed high expression of MMP-7, which was associated with tumour differentiation, invasiveness and clinical stage. The detection of MMP-7 positively correlated with the detection of VEGF-A in SACC.

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Availability of data and materials

All data generated or analyzed during this study are included in this published article.

Abbreviations

MMPs:

Matrix metalloproteinases

MMP-7:

Matrix metalloproteinase-7

ECM:

Extracellular matrix

SACC:

Adenoid cystic carcinoma of the salivary

ACC:

Adenoid cystic carcinoma

VEGF-A:

Vascular endothelial growth factor A

VEGF:

Vascular endothelial growth factor

CTGF:

Connective tissue growth factor

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, First People’s Hospital of Jiujiang City, Jiangxi Province, Jiujiang, 332000, China

    Haitao Liu & Haibo Zhou

  2. Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Nanchang University, No.49 Fuzhou Road, Nanchang, 320049, Jiangxi, China

    Linlin Chen

  3. Department of Pathology, First People’s Hospital of Jiujiang City, Jiangxi Province, Jiujiang, 332000, China

    Chenliang Wang

Authors
  1. Haitao Liu
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  2. Linlin Chen
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  4. Haibo Zhou
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Contributions

Conception and design of study: HL, LC. Acquisition of data: laboratory or clinical: CW, HZ. Analysis of data: HL, HZ. All authors helped drafting of article and/or critical revision. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Linlin Chen.

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Conflict of interest

All of the authors had no any personal, financial, commercial, or academic conflicts of interest separately.

Ethics approval and consent to participate

This study was conducted in accordance with the Declaration of Helsinki and approved by the ethics committee of First People's Hospital of Jiujiang City.

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Liu, H., Chen, L., Wang, C. et al. Matrix metalloproteinase 7 is associated with clinical and pathological characteristics of salivary adenoid cystic carcinomas. Eur Arch Otorhinolaryngol 280, 839–845 (2023). https://doi.org/10.1007/s00405-022-07630-1

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  • DOI: https://doi.org/10.1007/s00405-022-07630-1

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