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Incidence and survival trends in patients with primary tonsillar lymphoma: a large population-based study

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

This study aims to reveal changes in the incidence and prognosis of patients with tonsillar lymphoma on a population level.

Methods

The incidence, clinicopathological, and prognostic data of tonsillar lymphoma patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The Join-point software and R packages were utilized to analyze the annual percentage changes (APCs) and survival outcomes.

Results

The incidence of primary tonsillar lymphoma increased from 0.1204 per 100,000 person-years (95% CI, 0.0680–0.1962) in 1983 to 0.2158 (95% CI, 0.1675–0.2740) in 2015 with an APC of 1.20. When classified by decades, both cancer-specific survival (CSS) and overall survival (OS) improved with time. The 2006–2015 decade showed the highest rate of CSS and OS. Nevertheless, for disease-specific survival (DSS), the difference was not significant between 1996–2005 and 2006–2015 decades. The main cause of mortality among this cohort was heart diseases. Three nomograms were constructed to predict OS, CSS, and DSS for patients with primary tonsillar lymphoma, respectively. Histological subtype made the most contribution to poor prognosis in OS-predicting and CSS-predicting nomograms. While, for DSS, age at diagnosis made the most contribution to poor outcomes.

Conclusions

The incidence of primary tonsillar lymphoma has increased in the past decades. The OS and CSS rates of tonsillar lymphoma improved continuously, while there was no significant improvement in DSS in the past decades. These changes indicated an improved management of tonsillar lymphoma with newer therapeutic agents and the need of multi-disciplinary treatments to offset the future burden of noncancer diseases.

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Data availability

Data were publicly accessible which can be obtained in the SEER database.

Abbreviations

SEER:

The Surveillance, Epidemiology, and End Results (SEER) database

APC:

Annual percentage changes

CSS:

Cancer-specific survival

OS:

Overall survival

DSS:

Disease-specific survival

NHL:

Non-Hodgkin’s lymphoma

HL:

Hodgkin’s lymphoma

CI:

Confidence interval

DLBCL:

Diffuse large B cell lymphoma

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Acknowledgements

Thanks to all patients and authors who have con- tributed to the study.

Funding

No funds, grants, or other support was received.

Author information

Author notes

  1. Yan Liang and Haidong Zhang these authors have contributed equally to this work.

Authors and Affiliations

  1. Department of Hematology and Oncology, Xiangyang NO.1 People’s Hospital, Hubei University of Medcine, Xiangyang City, Hubei Province, China

    Yan Liang

  2. Oncology Department, Xiangyang NO.1 People’s Hospital, Hubei University of Medcine, Xiangyang City, Hubei Province, China

    Haidong Zhang

  3. Department of Medical Insurance and Price, Xiangyang NO.1 People’s Hospital, Hubei University of Medcine, No.15 Jiefang Road, Fancheng District, Xiangyang City, Hubei Province, China

    Yonghong Wu

  4. Digestive System Department, Xiangyang NO.1 People’s Hospital, Hubei University of Medcine, No.15 Jiefang Road, Fancheng District, Xiangyang City, Hubei Province, China

    Min Li

Authors
  1. Yan Liang
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  2. Haidong Zhang
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  3. Yonghong Wu
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  4. Min Li
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Contributions

YL: participated in the conception and design of this project, interpretation of data, and drafting. HZ: collected data and analysis. YW and ML: gave critical revision of the article and final approval of the manuscript to be submitted.

Corresponding authors

Correspondence to Yonghong Wu or Min Li.

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Conflict of interest

The authors declare no conflict of interest. There are no financial conflicts of interest to disclose.

Ethical approval

All data from the SEER database are de-identified prior to publication to the public, so the cases extracted from the SEER database do not contain any personal identifying information and, therefore, no ethical approval is required for this study.

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Liang, Y., Zhang, H., Wu, Y. et al. Incidence and survival trends in patients with primary tonsillar lymphoma: a large population-based study. Eur Arch Otorhinolaryngol 279, 4023–4032 (2022). https://doi.org/10.1007/s00405-022-07363-1

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  • DOI: https://doi.org/10.1007/s00405-022-07363-1

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