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Marital status and survival in laryngeal squamous cell carcinoma patients: a multinomial propensity scores matched study

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objective

To explore the correlation between the marital status and prognosis of patients with laryngeal squamous cell carcinoma (LSCC).

Study design

MPSM was adopted to minimize the maximum standardized average difference of the covariates among the four groups with different marital status.

Setting

Multinomial propensity scores matching (MPSM) based on data from the surveillance, epidemiology, and end results (SEER) database.

Methods

The Kaplan–Meier method and log-rank test were used to compare the survival outcomes of these groups with different marital status.

Results

Totally, 16,981 LSCC patients (median [IQR] age 62 [55–69] years; 829 [76.41%] males) from 2004 to 2016 were included in this study. Among them, 9112 (53.66%) were married, 2708 (15.95%) divorced or separated, 1709 (10.06%) widowed, and 3452 (20.33%) single. After MPSM, the weights make the characteristics of four groups with different marital status sufficient balance. The Kaplan–Meier method and log-rank test showed widowed patients may lead to the highest mortality rate while married patients have a higher survival rate than the other three groups. Single and divorced or separated patients had no significant difference in the survival rate. In addition, multivariate analysis by controlling for confounding factors showed that in male, well-differentiated, and early stage patients, compared with married, unmarried was an independent risk factor for CSS (P < 0.05).

Conclusion

Marital status showed a significant association with the survival status of LSCC patients. Importantly, the outcome of married patients was better, while widowed patients tended to have worse prognosis.

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Acknowledgements

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Author notes

  1. Xiushuai Du and Wenqiang Zhan contributed equally to this work.

Authors and Affiliations

  1. Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environment Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Xueyuan Road No. 1, Minhou County, Fuzhou, 350108, Fujian, People’s Republic of China

    Xiushuai Du, Xiaoqin Li, Shuo Yin, Qingquan Chen, Jialing Huang, Yao Chen & Jin Liu

  2. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China

    Wenqiang Zhan

Authors
  1. Xiushuai Du
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  2. Wenqiang Zhan
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  3. Xiaoqin Li
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  4. Shuo Yin
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  5. Qingquan Chen
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  6. Jialing Huang
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  7. Yao Chen
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  8. Jin Liu
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Contributions

XD: interpretation, drafting, critical revision, and data interpretation; WZ: interpretation and acquisition of data, approval, and accountable; XL: analysis and interpretation of data; SY: data interpretation and critical revision; QC: data interpretation and critical revision; JH: data interpretation; YC: review and revision of the manuscript; JL: conception and design, approval, and accountable; all the authors have read and approved the manuscript.

Corresponding author

Correspondence to Jin Liu.

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Du, X., Zhan, W., Li, X. et al. Marital status and survival in laryngeal squamous cell carcinoma patients: a multinomial propensity scores matched study. Eur Arch Otorhinolaryngol 279, 3005–3011 (2022). https://doi.org/10.1007/s00405-022-07252-7

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  • DOI: https://doi.org/10.1007/s00405-022-07252-7

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