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Comparison of the effects of platelet-rich plasma and dexamethasone ınjection on scar formation after vocal fold ınjury in rabbits

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objectives

In this study, a histopathological comparison was aimed between platelet-rich plasma (PRP) injection and dexamethasone injection in the prevention of scar formation after vocal fold injury.

Materials and methods

Electrocautery was applied to damage the right and left vocal folds of a total of 12 New Zealand rabbits. PRP obtained from the rabbit’s own blood was injected into the right vocal fold, and dexamethasone was injected into the left vocal fold. After 8 weeks, the experimental animals were euthanized, and the levels of inflammatory cell infiltration, vascularization, collagen, elastin, and hyaluronic acid (HA) were compared in histopathological evaluation.

Results

In statistical comparison of histopathological data obtained; in terms of plasma cell infiltration, vascularization, and edema parameters, statistically significant results were obtained in favor of the PRP group. Although the difference between collagen, elastin and HA, which are critical in vocal fold scar healing, was more positive in favor of PRP, no significant result was revealed in the statistical evaluation.

Conclusions

PRP injection in rabbits with vocal fold damage reveals similar characteristics with dexamethasone injection in preventing scar formation. PRP injection has favorable effects on vascularization, prevention of edema, and number of plasma cells.

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Availability of data and materials

The data sets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Code availability

No code available.

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Funding

This project was supported by Hacettepe University Scientific Research Projects (Grant Number: 18399).

Author information

Authors and Affiliations

  1. Department of Otolaryngology, Dr Nafiz Körez Hospital, Sincan, Ankara, Turkey

    Görkem Dündar

  2. Department of Otolaryngology, Hacettepe University, Sıhhiye, Ankara, Turkey

    Önder Günaydın & Taner Yılmaz

  3. Department of Pathology, Hacettepe University, Sıhhiye, Ankara, Turkey

    Olcay Kurtulan & Gaye Güler Tezel

Authors
  1. Görkem Dündar
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  2. Önder Günaydın
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  3. Taner Yılmaz
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  4. Olcay Kurtulan
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  5. Gaye Güler Tezel
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Contributions

All authors meet the ICMJE authorship criteria. All authors have seen and approved the final version of the manuscript, and contributed significantly to the work. Material preparation and data collection were performed by GD, OG, and TY. The histopathological analysis of the data was performed by OK and GGT. The first draft of the manuscript was written by GD, OG, and TY and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Görkem Dündar.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Our study was carried out on receiving the approval of Hacettepe University Experimental Animals Ethical Board, No. 2019/08-11.

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Dündar, G., Günaydın, Ö., Yılmaz, T. et al. Comparison of the effects of platelet-rich plasma and dexamethasone ınjection on scar formation after vocal fold ınjury in rabbits. Eur Arch Otorhinolaryngol 279, 1405–1411 (2022). https://doi.org/10.1007/s00405-021-07154-0

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  • DOI: https://doi.org/10.1007/s00405-021-07154-0

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