Skip to main content

Advertisement

SpringerLink
Log in

Effects of hyaluronic acid on the bone healing after lateral osteotomy: an experimental animal model

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objective

Postoperative comfort of the patients undergoing rhinoplasty might be poor because of edema and ecchymosis caused by lateral osteotomy. In this animal experiment, we aimed at performing a quantitative assessment of effects of hyaluronic acid usage on healing process of lateral osteotomy.

Methods

Fourteen New Zealand rabbits with a weight of 2000–2500 kg and an age of 8–12 weeks were included. Under anesthesia, nasal dorsums were exposed with midline incision and lateral osteotomies on both sides were performed using a 2 mm chisel. A hyaluronic acid-based mesh (Hyalonect®) (1 × 1 cm) was embedded on the left osteotomy areas of all rabbits. Right osteotomy areas were left blank as control group. Collagen density and capillary development were quantitatively compared.

Results

Convergence of fracture lines was observed in 6 (60%) of 10 samples from Hyalonect® group, while was observed in 4 (40%) of 10 samples from control group. Although a higher rate of convergence was seen in the Hyalonect® group (60% vs 40%), the difference was not statistically significant (p = 0.5). Median collagen score was 2 (1–3) in the Hyalonect® group and 1 (1–2) in the control group. Median capillary count value was 4 (1–23) in the Hyalonect® group and 3 (1–17) in the control group. Both collagen score and capillary count values were significantly greater in the in the Hyalonect® group compared with the control group (p = 0.023 and p = 0.019, respectively).

Conclusion

The effects of hyaluronic acid-based meshes on the bone healing process of the lateral osteotomy area might be investigated furthermore, on more comprehensive studies, as a material facilitating collagen organization and capillary development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Bektas G, Cinpolat A, Rizvanovic Z (2020) Nasal filling in plastic surgery practice: primary nasal filling, nasal filling for post-rhinoplasty defects, rhinoplasty after hyaluronidase injection in dissatisfied nasal filling patients. Aesthetic Plast Surg 44(6):2208–2218. https://doi.org/10.1007/s00266-020-01895-9

    Article  PubMed  Google Scholar 

  2. Bertossi D, Malchiodi L, Albanese M, Nocini R, Nocini P (2020) Nonsurgical rhinoplasty with the novel hyaluronic acid filler VYC-25L: results using a nasal grid approach. Aesthet Surg J. https://doi.org/10.1093/asj/sjaa196

    Article  Google Scholar 

  3. Kassir R, Venkataram A, Malek A, Rao D (2020) Non-surgical rhinoplasty: the ascending technique and a 14-year retrospective study of 2130 cases. Aesthetic Plast Surg. https://doi.org/10.1007/s00266-020-02048-8

    Article  PubMed  Google Scholar 

  4. Rho NK, Youn CS, Youn SJ, Lee S, Kim HS (2021) A comparison of the safety, efficacy, and longevity of two different hyaluronic acid fillers in filler rhinoplasty: a multicenter study. Dermatol Ther 34(1):e14707. https://doi.org/10.1111/dth.14707

    Article  CAS  PubMed  Google Scholar 

  5. Bian X, Liu H, Sun J, Zhang X, Li N, Chen M (2020) Efficacy of dexamethasone for reducing edema and ecchymosis after rhinoplasty: a systematic review and meta-analysis. Aesthetic Plast Surg 44(5):1672–1684. https://doi.org/10.1007/s00266-020-01743-w

    Article  PubMed  Google Scholar 

  6. Hanci D, Üstün O, Yılmazer AB, Göker AE, Karaketir S, Uyar Y (2020) Evaluation of the efficacy of hilotherapy for postoperative edema, ecchymosis, and pain after rhinoplasty. J Oral Maxillofac Surg 78(9):1628.e1621-1628.e1625. https://doi.org/10.1016/j.joms.2020.03.032

    Article  Google Scholar 

  7. Karimi S, Sadeghi M, Amali A, Saedi B (2020) Effect of photobiomodulation on ecchymosis after rhinoplasty: a randomized single-blind controlled trial. Aesthetic Plast Surg 44(5):1685–1691. https://doi.org/10.1007/s00266-020-01760-9

    Article  PubMed  Google Scholar 

  8. Rostami K, Shahaboddin MA, Niazi F, Karimi Rouzbahani A, Nadri S, Mahmoudvand H (2020) The effect of hirodoid cream on ecchymosis and edema around eyes after rhinoplasty. World J Plast Surg 9(2):128–134. https://doi.org/10.29252/wjps.9.2.128

    Article  PubMed  PubMed Central  Google Scholar 

  9. Tandelilin RT, Sofro ASM, Soesatyo MH, Asmara W (2006) The density of collagen fiber in alveolus mandibular bone of rabbit after augmentation with powder demineralized bone matrix post incisivus extraction. Dent J 39(2):43–47. https://doi.org/10.20473/j.djmkg.v39.i2.p43-47

    Article  Google Scholar 

  10. Locketz GD, Lozada KN, Becker DG (2020) Osteotomies—when, why, and how? Facial Plast Surg 36(1):57–65. https://doi.org/10.1055/s-0040-1701478

    Article  CAS  PubMed  Google Scholar 

  11. Chen WY, Abatangelo G (1999) Functions of hyaluronan in wound repair. Wound Repair Regen 7(2):79–89. https://doi.org/10.1046/j.1524-475x.1999.00079.x

    Article  CAS  PubMed  Google Scholar 

  12. Saliba I, Alzahrani M, Zhu T, Chemtob S (2014) Growth factors expression in hyaluronic acid fat graft myringoplasty. Laryngoscope 124(6):E224-230. https://doi.org/10.1002/lary.24468

    Article  PubMed  Google Scholar 

  13. Güneri EA, Tekin S, Yilmaz O, Ozkara E, Erdağ TK, Ikiz AO, Sarioğlu S, Güneri A (2003) The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of acute traumatic tympanic membrane perforation. Otol Neurotol 24(3):371–376. https://doi.org/10.1097/00129492-200305000-00004

    Article  PubMed  Google Scholar 

  14. Dessy LA, Mazzocchi M, Rizzo MI, Onesti MG, Scuderi G (2013) Scalp reconstruction using dermal induction template: state of the art and personal experience. In Vivo 27(1):153–158

    PubMed  Google Scholar 

  15. Jang CH, Park H, Cho YB, Choi CH (2008) The effect of anti-adhesive packing agents in the middle ear of guinea pig. Int J Pediatr Otorhinolaryngol 72(11):1603–1608. https://doi.org/10.1016/j.ijporl.2008.07.012

    Article  PubMed  Google Scholar 

  16. Simman R, Mari W, Younes S, Wilson M (2018) Use of hyaluronic acid-based biological bilaminar matrix in wound bed preparation: a case series. Eplasty 18:e17

    PubMed  PubMed Central  Google Scholar 

  17. Chareancholvanich K, Pornrattanamaneewong C, Narkbunnam R (2014) Increased cartilage volume after injection of hyaluronic acid in osteoarthritis knee patients who underwent high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 22(6):1415–1423. https://doi.org/10.1007/s00167-013-2735-1

    Article  PubMed  Google Scholar 

  18. Otsuki S, Nakajima M, Lotz M, Kinoshita M (2008) Hyaluronic acid and chondroitin sulfate content of osteoarthritic human knee cartilage: site-specific correlation with weight-bearing force based on femorotibial angle measurement. J Orthop Res 26(9):1194–1198. https://doi.org/10.1002/jor.20571

    Article  PubMed  Google Scholar 

Download references

Funding

This project was funded by the Scientific Research Project Unit of Giresun University.

Author information

Authors and Affiliations

  1. Department of Otolaryngology, Faculty of Medicine, Giresun University, 28200, Giresun, Turkey

    Guven Yildirim

  2. Department of Otolaryngology, Bilkent City Hospital, 06100, Ankara, Turkey

    Kursat Murat Ozcan

  3. Department of Histology and Embryology, Faculty of Medicine, Giresun University, 28200, Giresun, Turkey

    Zuleyha Erisgin

  4. Department of Otolaryngology, Faculty of Medicine, Balikesir University, 10145, Balıkesir, Turkey

    Omer Hizli

  5. Department of Otolaryngology, Giresun Ilhan Ozdemir Research Hospital, 28200, Giresun, Turkey

    Cengiz Sivrikaya

Authors
  1. Guven Yildirim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kursat Murat Ozcan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zuleyha Erisgin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Omer Hizli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Cengiz Sivrikaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Omer Hizli.

Ethics declarations

Conflict of interest

The authors have no conflict of interest to declare.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of local ethical committee of Giresun University for animal experiments (Number: 2017/18).

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yildirim, G., Ozcan, K.M., Erisgin, Z. et al. Effects of hyaluronic acid on the bone healing after lateral osteotomy: an experimental animal model. Eur Arch Otorhinolaryngol 279, 2959–2964 (2022). https://doi.org/10.1007/s00405-021-07096-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-021-07096-7

Keywords

Search

Navigation