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Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children

  • Head and Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 20 October 2021

Abstract

Introduction

In this study we aimed to compare the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children.

Materials and methods

In this randomized double-blind clinical trial study 60 children with ASA = I–II aged 5–12 years undergoing tonsillectomy were involved. The first group received bupivacaine at a dose of 0.1 mg/kg that was injected into the bed and the anterior crease of each tonsil. The second group was given intravenous acetaminophen at a dose of 12.5 mg/kg. The patient’s pain score at 10, 30, 60 min after his/her admission to recovery room and 120, 240 and 360 min after the surgery was recorded using CHEOPS. Patient’s sedation score, nausea or vomiting, the time of the first request for analgesia and the time of starting oral feeding were recorded and analyzed too.

Results

There was no significant differences in mean age (p value = 0.44), gender (p value = 0.79), weight (p value = 0.36), height (p value = 0.17), anesthesia duration (p.value = 0.85) and surgery duration (p.value = 0.73) between two groups. Postoperative pain was significantly less in the bupivacaine group at 240 and 360 min after the surgery. The mean sedation score was higher in the bupivacaine group but not significantly. There was no significant difference between groups regarding the nausea and vomiting, the first analgesics request time and the start time of oral feeding.

Conclusion

According to the results of the present study, since administration of peritonsillar bupivacaine compared to acetaminophen had a better effect on managing postoperative pain and improving sedation and also since no complications were reported; therefore, peritonsillar infiltration with bupivacaine is suggested for pediatric tonsillectomy.

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Authors and Affiliations

  1. Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Habibollah Hosseini, Maryam Shariatmadari & Vida Ayatollahi

  2. Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Sedighe Vaziribozorg & Mojtaba Meybodian

Authors
  1. Habibollah Hosseini
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  2. Maryam Shariatmadari
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  3. Vida Ayatollahi
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  4. Sedighe Vaziribozorg
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  5. Mojtaba Meybodian
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Corresponding author

Correspondence to Mojtaba Meybodian.

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Authors have no conflicts of interest.

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Study protocol was in accordance with the latest Declaration of Helsinki for medical research involving human subjects and was approved by the local ethics committee.

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Informed consent was obtained from all participants of the study.

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Hosseini, H., Shariatmadari, M., Ayatollahi, V. et al. Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children. Eur Arch Otorhinolaryngol 279, 2599–2602 (2022). https://doi.org/10.1007/s00405-021-07049-0

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  • DOI: https://doi.org/10.1007/s00405-021-07049-0

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