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Long-term stability of results following surgery for obstructive sleep apnea (OSA)

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A Correction to this article was published on 23 June 2021

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Abstract

Purpose

Although upper airway surgery in selected patients with obstructive sleep apnea (OSA) has been shown to be beneficial, its long-term effects have been questioned. The main objective was to evaluate whether results following surgery remain stable over time, both in objective and subjective terms. As a secondary aim, such stability was also measured in relation with the type of surgery performed.

Methods

This work constitutes a retrospective study of OSA adult patients subjected to the following surgical procedures: different types of pharyngoplasties, tongue-base surgery, partial epiglottectomy or hyoid suspension. Those who exclusively underwent tonsillectomy or nasal surgery were excluded. Before surgery, a sleep study, and an assessment of the patients’ sleepiness and quality of life were performed, which were repeated at 8, 34, and 48 months after surgery. A total of 153 patients was included.

Results

Following surgery, the apnea–hypopnea index decreased from 34.84/h to 14.54/h and did not vary more than one point in subsequent controls (p = 0.01). The oxygen desaturation index changed from 31.02/h to 14.0/h and remained stable in the second (15.34/h) and third (11.43/h) controls (p = 0.01). Parameters measuring sleepiness and well-being demonstrated the maintenance of long-term benefits. New pharyngoplasties were observed to be more stable than classic pharyngoplasties in the long term (p = 0.04). Single-level surgeries were found to be more stable than multilevel surgeries, although a statistically significant difference was not observed (p = 0.07).

Conclusion

The benefits obtained remained stable in the long term. In our sample, modern pharyngoplasty techniques showed superiority over the classic ones regarding long-term stability.

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References

  1. Sommer UJ, Heiser C, Gahleitner C et al (2016) Tonsillectomy with uvulopalatopharyngoplasty in obstructive sleep apnea. Dtsch Arzteblatt Int 113:1–8. https://doi.org/10.3238/arztebl.2016.0001

    Article  Google Scholar 

  2. Vicini C, Meccariello G, Montevecchi F et al (2020) Effectiveness of barbed repositioning pharyngoplasty for the treatment of obstructive sleep apnea (OSA): a prospective randomized trial. Sleep Breath Schlaf Atm 24:687–694. https://doi.org/10.1007/s11325-019-01956-7

    Article  Google Scholar 

  3. Senchak AJ, McKinlay AJ, Acevedo J et al (2015) The effect of tonsillectomy alone in adult obstructive sleep apnea. Otolaryngol-Head Neck Surg 152:969–973. https://doi.org/10.1177/0194599815575721

    Article  PubMed  Google Scholar 

  4. Holmlund T, Franklin KA, Levring Jäghagen E et al (2016) Tonsillectomy in adults with obstructive sleep apnea. Laryngoscope 126:2859–2862. https://doi.org/10.1002/lary.26038

    Article  PubMed  Google Scholar 

  5. MacKay S, Carney AS, Catcheside PG et al (2020) Effect of multilevel upper airway surgery vs medical management on the apnea-hypopnea index and patient-reported daytime sleepiness among patients with moderate or severe obstructive sleep apnea: the SAMS randomized clinical trial. JAMA 324:1168–1179. https://doi.org/10.1001/jama.2020.14265

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ruiz M, de Apodaca P, Carrasco Llatas M, Valenzuela Gras M, Dalmau Galofre J (2020) Improving surgical results in velopharyngeal surgery: our experience in the last decade. Acta Otorrinolaringol Esp 71:197–203. https://doi.org/10.1016/j.otorri.2019.06.001

    Article  Google Scholar 

  7. Sher AE, Schechtman KB, Piccirillo JF (1996) The efficacy of surgical modifications of the upper airway in adults with obstructive sleep apnea syndrome. Sleep 19:156–177. https://doi.org/10.1093/sleep/19.2.156

    Article  CAS  PubMed  Google Scholar 

  8. Zinchuk AV, Gentry MJ, Concato J, Yaggi HK (2017) Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches. Sleep Med Rev 35:113–123. https://doi.org/10.1016/j.smrv.2016.10.002

    Article  PubMed  Google Scholar 

  9. Lee KC, Chuang S-K, Mehra P (2020) Should multilevel phase I surgical therapy be recommended as treatment for moderate obstructive sleep apnea due to oropharyngeal and hypopharyngeal obstruction? J Oral Maxillofac Surg 78:2282–2288. https://doi.org/10.1016/j.joms.2020.08.005

    Article  PubMed  Google Scholar 

  10. He M, Yin G, Zhan S et al (2019) Long-term efficacy of uvulopalatopharyngoplasty among adult patients with obstructive sleep apnea: a systematic review and meta-analysis. Otolaryngol-Head Neck Surg 161:401–411. https://doi.org/10.1177/0194599819840356

    Article  PubMed  Google Scholar 

  11. Despeghel A-S, Mus L, Dick C et al (2017) Long-term results of a modified expansion sphincter pharyngoplasty for sleep-disordered breathing. Eur Arch Oto-Rhino-Laryngol 274:1665–1670. https://doi.org/10.1007/s00405-016-4395-5

    Article  Google Scholar 

  12. Shimada A, Konno A, Isono S (2000) Long-term result after UPPP for OSAS by evaluation of nocturnal oxygenation. Nihon Rinsho Jpn J Clin Med 58:1681–1684

    CAS  Google Scholar 

  13. Meoli AL, Casey KR, Clark RW et al (2001) Hypopnea in sleep-disordered breathing in adults. Sleep 24:469–470

    CAS  PubMed  Google Scholar 

  14. Iber C, Ancoli-Israel S, Cheson AL Jr, Quan SF (2007) The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, 1st edn. American Academy of Sleep Medicine, Westchester

    Google Scholar 

  15. Berry RB, Budhiraja R, Gottlieb DJ et al (2012) Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine. J Clin Sleep Med 8:597–619. https://doi.org/10.5664/jcsm.2172

    Article  PubMed  PubMed Central  Google Scholar 

  16. Friedman M, Tanyeri H, La Rosa M et al (1999) Clinical predictors of obstructive sleep apnea. Laryngoscope 109:1901–1907. https://doi.org/10.1097/00005537-199912000-00002

    Article  CAS  PubMed  Google Scholar 

  17. Esteller E, Carrasco M, Díaz-Herrera MÁ et al (2019) Clinical practice guideline recommendations on examination of the upper airway for adults with suspected obstructive sleep apnoea-hypopnoea syndrome. Acta Otorrinolaringol Esp 70:364–372. https://doi.org/10.1016/j.otorri.2018.06.008

    Article  Google Scholar 

  18. Carrasco Llatas M, Ruiz M, de Apodaca P, Baptista Jardín P et al (2020) Drug-induced sleep endoscopy. Acta Otorrinolaringol Esp 71:316–320. https://doi.org/10.1016/j.otorri.2019.02.007

    Article  Google Scholar 

  19. Fujita S, Conway W, Zorick F, Roth T (1981) Surgical correction of anatomic azbnormalities in obstructive sleep apnea syndrome: uvulopalatopharyngoplasty. Otolaryngol-Head Neck Surg 89:923–934. https://doi.org/10.1177/019459988108900609

    Article  CAS  PubMed  Google Scholar 

  20. Cahali MB (2003) Lateral pharyngoplasty: a new treatment for obstructive sleep apnea hypopnea syndrome. Laryngoscope 113:1961–1968. https://doi.org/10.1097/00005537-200311000-00020

    Article  PubMed  Google Scholar 

  21. Pang KP, Woodson BT (2007) Expansion sphincter pharyngoplasty: a new technique for the treatment of obstructive sleep apnea. Otolaryngol-Head Neck Surg 137:110–114. https://doi.org/10.1016/j.otohns.2007.03.014

    Article  PubMed  Google Scholar 

  22. Carrasco Llatas M, Valenzuela Gras M, Ruiz M, de Apodaca P, Dalmau Galofre J (2020) Modified reposition pharyngoplasty for OSAS treatment: how we do it and our results. Acta Otorrinolaringol Esp. https://doi.org/10.1016/j.otorri.2020.02.010

    Article  Google Scholar 

  23. Woodson BT, Laohasiriwong S (2012) Lingual tonsillectomy and midline posterior glossectomy for obstructive sleep apnea. Oper Tech Otolaryngol-Head Neck Surg 23:155–161

    Article  Google Scholar 

  24. Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14:540–545. https://doi.org/10.1093/sleep/14.6.540

    Article  CAS  PubMed  Google Scholar 

  25. Spanish Group of Breathing Sleep Disorders, Masa JF, Jiménez A et al (2011) Visual analogical well-being scale for sleep apnea patients validity and responsiveness a test for clinical practice. Sleep Breath Schlaf Atm 15:549–559. https://doi.org/10.1007/s11325-010-0399-3

    Article  Google Scholar 

  26. Browaldh N, Bring J, Friberg D (2018) SKUP3: 6 and 24 months follow-up of changes in respiration and sleepiness after modified UPPP. Laryngoscope 128:1238–1244. https://doi.org/10.1002/lary.26835

    Article  PubMed  Google Scholar 

  27. Browaldh N, Friberg D, Svanborg E, Nerfeldt P (2011) 15-year efficacy of uvulopalatopharyngoplasty based on objective and subjective data. Acta Otolaryngol (Stockh) 131:1303–1310. https://doi.org/10.3109/00016489.2011.616912

    Article  Google Scholar 

  28. Friberg D, Sundman J, Browaldh N (2020) Long-term evaluation of satisfaction and side effects after modified uvulopalatopharyngoplasty. Laryngoscope 130:263–268. https://doi.org/10.1002/lary.27917

    Article  PubMed  Google Scholar 

  29. Durán J, Esnaola S, Rubio R, Iztueta A (2001) Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am J Respir Crit Care Med 163:685–689. https://doi.org/10.1164/ajrccm.163.3.2005065

    Article  PubMed  Google Scholar 

  30. Lin J, Suurna M (2018) Sleep apnea and sleep-disordered breathing. Otolaryngol Clin North Am 51:827–833. https://doi.org/10.1016/j.otc.2018.03.009

    Article  PubMed  Google Scholar 

  31. Costantino A, Rinaldi V, Moffa A et al (2020) Hypoglossal nerve stimulation long-term clinical outcomes: a systematic review and meta-analysis. Sleep Breath Schlaf Atm 24:399–411. https://doi.org/10.1007/s11325-019-01923-2

    Article  Google Scholar 

  32. Iannella G, Magliulo G, Montevecchi F et al (2019) Lingual tonsil lymphatic tissue regrowth in patients undergoing transoral robotic surgery. Laryngoscope 129:2652–2657. https://doi.org/10.1002/lary.27775

    Article  PubMed  Google Scholar 

  33. Mansukhani MP, Kolla BP, Wang Z, Morgenthaler TI (2019) Effect of varying definitions of hypopnea on the diagnosis and clinical outcomes of sleep-disordered breathing: a systematic review and meta-analysis. J Clin Sleep Med 15:687–696. https://doi.org/10.5664/jcsm.7750

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Marina Carrasco-Llatas.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethics approval for retrospective studies

This work fits the compliance with Ethical Standards. The competent authority’s ethics committee approved this study, and informed consent was obtained before surgery from all patients included in this work. Approval code: CEim 82/19.

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This article is part of the Topical Collection on sleep apnea syndrome. Guest Editors: Manuele Casale, Rinaldi Vittorio.

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Martínez-Ruíz de Apodaca, P., Carrasco-Llatas, M., Matarredona-Quiles, S. et al. Long-term stability of results following surgery for obstructive sleep apnea (OSA). Eur Arch Otorhinolaryngol 279, 373–380 (2022). https://doi.org/10.1007/s00405-021-06781-x

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