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Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to assess the performance of Narrow Band Imaging (NBI) added to White Light (WL) in the delineation of laryngopharyngeal superficial cancer spread during office-based transnasal flexible endoscopy.

Methods

This bi-centric prospective study was conducted between October 2014 and December 2017. We included consecutive patients with laryngopharyngeal malignant tumors. Transnasal flexible endoscopy was performed by two endoscopists who were blinded to each other's assessments and who examined each patient independently. The first endoscopist only performed a WL examination, while the second endoscopist carried out both WL and NBI. The extent of tumor involvement was reported based on predefined anatomical sub-units. Biopsies in NBI + /WL− sub-units were subsequently performed during panendoscopy.

Results

Eighty-four patients were included in the study. A total of 72 NBI + /WL− sub-units were sampled in 38 patients, and 37 of the biopsies were positive (51.4%): 16 for invasive carcinoma, 17 for high-grade dysplasia/carcinoma in situ and 4 for low-grade dysplasia. Ultimately, 26.2% of patients had at least one positive biopsy in an NBI + /WL− sub-unit and, therefore, a better tumor delineation. The clinical T stage was upgraded in 4.8% of cases examined.

Conclusion

Adding NBI to WL imaging during transnasal flexible endoscopy in patients presenting with laryngopharyngeal pre-malignant or malignant lesions improves the delineation of superficial cancer spread, thereby leading to better adapted treatments.

Clinicaltrials.gov registration number: NCT02035735.

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Data availability

The corresponding authors declares to be able to disclose all the data regarding this study.

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Acknowledgements

The authors thank the “Direction de la Recherche et de l’Innovation” of the Toulouse University Hospital for their financial and linguistic support.

Funding

The authors received institutional support from the “Direction de la Recherche et de l’Innovation” of the Toulouse University Hospital through an “Appel d’Offre Local”.

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Authors and Affiliations

  1. Department of ENT-Head and Neck Surgery, University Cancer Institute Toulouse and Toulouse University Hospital, Hôpital Larrey, 24 Chemin de Pouvourville, 31059, Toulouse, France

    Emilien Chabrillac, Gaël Espinasse, Guillaume De Bonnecaze & Sébastien Vergez

  2. Department of Surgery, University Cancer Institute Toulouse-Oncopole, 1 Avenue Irène Joliot-Curie, 31059, Toulouse, France

    Gaël Espinasse, Agnès Dupret-Bories & Sébastien Vergez

  3. Department of Epidemiology, Toulouse University Hospital, USMR, 37 Allées Jules Guesde, 31073, Toulouse, France

    Benoît Lepage

  4. Department of Pathology, University Cancer Institute Toulouse and Toulouse University Hospital, 1 Avenue Irène Joliot-Curie, 31059, Toulouse, France

    Emmanuelle Uro-Coste

Authors
  1. Emilien Chabrillac
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  2. Gaël Espinasse
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  3. Benoît Lepage
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  4. Emmanuelle Uro-Coste
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  5. Agnès Dupret-Bories
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  6. Guillaume De Bonnecaze
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  7. Sébastien Vergez
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Corresponding author

Correspondence to Emilien Chabrillac.

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The authors have no conflicts of interest to declare.

Ethics approval (include appropriate approvals or waivers)

Our study protocol was approved by the research ethics committee (n° 1-13-46) and by the institutional review board of each participating institution.

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All patients gave their written informed consent to participate in this research.

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All authors participated and gave their consent to the publication of this study.

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Chabrillac, E., Espinasse, G., Lepage, B. et al. Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study. Eur Arch Otorhinolaryngol 278, 1491–1497 (2021). https://doi.org/10.1007/s00405-020-06499-2

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  • DOI: https://doi.org/10.1007/s00405-020-06499-2

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