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Narrow Band Imaging Technology: Role in the Detection of Recurrent Laryngeal and Hypopharyngeal Cancers Post-radiotherapy

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Abstract

To assess the diagnostic accuracy of NBI endoscopy for the diagnosis of early recurrent laryngeal and hypopharyngeal cancers after radiotherapy. The study was conducted over a period of two and a half years from June 2019 to February 2022 and included 123 post-RT patients with laryngeal and hypopharyngeal cancers. The patients were planned for endoscopy with white light and narrow-band imaging. The biopsy was carried out in NBI suspected lesions and sent for histopathological examination. The pathologist was blinded to the outcome of NBI and WLE results to eliminate observer bias. The age group most commonly affected in our study was 40–50 years. Out of the 123 patients, 106 were males and 17 were females. The overall Sensitivity, Specificity, Positive predictive value and Negative predictive value of NBI for malignant lesions were 90.6%, 99%, 95.2% and 98% respectively. NBI Technology is a first-rate diagnostic tool that can help in diagnosing early recurrent cancer lesions, especially after RT, in which the recurrence is otherwise difficult to differentiate from post-radiotherapy oedema. This technology can significantly reduce the rates of failure to detect cancers in early stages.

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References

  1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T et al (2008) Cancer statistics. CA A Cancer J Clin 58:71–96

    Article  Google Scholar 

  2. Blitz AM, Aygun N (2008) Radiologic evaluation of larynx cancer. Otolaryngol Clin North Am 41:697–713

    Article  PubMed  Google Scholar 

  3. Mannelli G, Cecconi L, Gallo O (2016) Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis. Crit Rev Oncol Hematol 106:64–90

    Article  PubMed  Google Scholar 

  4. Little SG, Rice TW, Bybel B, Mason DP, Murthy GW, Falk LA et al (2007) Is FDG-PET indicated for superficial esophageal cancer? Eur J Cardiothorac Surg 31:791–796

    Article  PubMed  Google Scholar 

  5. Miyata H, Doki Y, Yasuda T, Yamasaki M, Higuchu I, Makari Y et al (2008) Evaluation of clinical significance of 18F-fluorodeoxyglucose positron emission tomography in superficial squamous cell carcinomas of the thoracic esophagus. Dis Esophagus Off J Int Soc Dis Esophagus 21:144–150

    Article  CAS  Google Scholar 

  6. Fielding D, Agnew J, Wright D, Hodge R (2010) Autofluorescence improves pretreatment mucosal assessment in head and neck cancer patients. Otolaryngol Head Neck Surg 142(3 Suppl 1):20–26

    Google Scholar 

  7. Hughes OR, Stone N, Kraft M, Arens C, Birchall MA (2010) Optical and molecular techniques to identify tumor margins within the larynx. Head Neck 32(11):1544–1553

    Article  PubMed  Google Scholar 

  8. Muto M, Nakane M, Katada C, Sano Y, Ohtsu A, Esumi H, Ebihara S, Yoshida S (2004) Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites. Cancer 101(6):1375–1381

    Article  PubMed  Google Scholar 

  9. Sano Y, Kobayashi M, Hamamoto Y et al (2001) New diagnostic method based on color imaging using narrowband imaging (NBI) endoscopy system for gastrointestinal tract. Gastrointestinal Endoscop 53(5):AB125

    Google Scholar 

  10. Gono K, Obi T, Yamaguchi M, Ohyama N, Machida H, Sano Y (2004) Appearance of enhanced tissue features in narrow-band endoscopic imaging. J Biomed Opt 9:568–577

    Article  PubMed  Google Scholar 

  11. Rennemo E et al (2008) Impact of second primary tumors on survival in head and neck cancer: an analysis of 2,063 cases. Laryngoscope 118(8):1350–1356

    Article  PubMed  Google Scholar 

  12. Cooper JS (1995) Late effects of radiation therapy in the head and neck region. Int J Radiat Oncol Biol Phys 31(5):1141–1164

    Article  CAS  PubMed  Google Scholar 

  13. Sharma S, Sharma MC, Sarkar C (2005) Morphology of angiogenesis in human cancer: a conceptual overview, histo-prognostic perspective and significance of neoangiogenesis. Histopathology 46(5):481–489

    Article  CAS  PubMed  Google Scholar 

  14. Lukes P, Zabrodsky M, Plzak J, Chovanec M, Betka J, Foltynova E, Betka J (2013) Narrow band imaging (NBI)-endoscopic method for detection of head and neck cancer. endoscopy. Somchai Amornyotin. IntechOpen

  15. Watanabe A, Taniguchi M, Tsujie H, Hosokawa M, Fujita M, Sasaki S (2009) The value of narrow band imaging for early detection of laryngeal cancer. Eur Arch Oto Rhino Laryngol 266:1017–1023

    Article  Google Scholar 

  16. Bertino G, Cacciola S, Fernandes WB, Fernandes CM, Occhini A, Tinelli C, Benazzo M (2015) Effectiveness of narrow band imaging in the detection of premalignant and malignant lesions of the larynx: validation of a new endoscopic clinical classification. Head Neck 37:215–222

    Article  PubMed  Google Scholar 

  17. Ni XG, He S, Xu ZG, Gao L, Lu N, Yuan Z, Lai SQ, Zhang YM, Yi JL, Wang XL et al (2011) Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging. J Laryngol Otol 125:288–296

    Article  PubMed  Google Scholar 

  18. Watanabe A, Tsujie H, Taniguchi M, Hosokawa M, Fujita M, Sasaki S (2006) Laryngoscopic detection of pharyngeal carcinoma in situ with narrowband imaging. Laryngoscope 116(4):650–654

    Article  PubMed  Google Scholar 

  19. Ganly I, Patel SG, Matsuo J et al (2006) Results of surgical salvage after failure of definitive radiation therapy for early stage squamous cell carcinoma of the glottic larynx. Arch Otolaryngol Head Neck Surg 132(1):59–66

    Article  PubMed  Google Scholar 

  20. Dörr W, Hamilton CS, Boyd T, Reed B, Denham JW (2002) Radiation induced changes in cellularity and proliferation in human oral mucosa. Int J Radiat Oncol Biol Phys 52(4):911–917

    Article  PubMed  Google Scholar 

  21. Zbaren P, Christe A, Caversaccio MD, Stauffer E, Thoeny HC (2007) Pretherapeutic staging of recurrent laryngeal carcinoma: clinical findings and imaging studies compared with histopathology. Otolaryngol Head Neck Surg 137(3):487–491

    Article  PubMed  Google Scholar 

  22. Piazza C, Dessouky O, Peretti G, Cocco D, De Benedetto L, Nicolai P (2008) Narrowband imaging: a new tool for evaluation of head and neck squamous cell carcinomas: review of the literature. Acta Otorhinolaryngol Ital 28(2):49–54

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Kim JW, Roh JL, Kim JS et al (2013) PET/CT surveillance at 3–6 and 12 months for detection of recurrence and second primary cancer in patients with head and neck squamous cell carcinoma. Br J Cancer 109(12):2973–2979

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Kostakoglu L, Fardanesh R, Posner M (2013) Early detection of recurrent disease by FDG-PET/CT leads to management changes in patients with squamous cell cancer of the head and neck. Oncologist 18(10):1108–1117

    Article  PubMed  PubMed Central  Google Scholar 

  25. Lin Y, Watanabe A, Chen W, Lee K, Lee I, Wang W (2010) Narrowband imaging for early detection of malignant tumors and radiation effect after treatment of head and neck cancer. Arch Otolaryngol Head Neck Surg 136(3):234–239

    Article  PubMed  Google Scholar 

  26. Zábrodský M, Lukes P, Lukesova J, Boucek J, Plzák J (2014) The role of narrow band imaging in the detection of recurrent laryngeal and hypopharyngeal cancer after curative radiotherapy. BioMed Res Int. https://doi.org/10.1155/2014/175398

    Article  PubMed  PubMed Central  Google Scholar 

  27. Galli J, Settimi S, Mele DA, Salvati A, Schiavi E, Parrilla C, Paludetti G (2021) Role of narrow band imaging technology in the diagnosis and follow up of laryngeal lesions: assessment of diagnostic accuracy and reliability in a large patient cohort. J Clin Med 10:1224. https://doi.org/10.3390/jcm10061224

    Article  PubMed  PubMed Central  Google Scholar 

  28. Lin C, Zhang S, Lu L, Wang M, Qian X (2020) Diagnostic value and pathological correlation of narrow band imaging classification in laryngeal lesions. Ear Nose Throat J 8:145561320925327

    Google Scholar 

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The author confirms responsibility for study conception and design, data collection, analysis and interpretation of results and manuscript preparation.

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Correspondence to Faizah Ashfah Latief Deva.

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The author declares that she has no financial interest.

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Approval was obtained from the ethics committee of our college. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Deva, F.A.L. Narrow Band Imaging Technology: Role in the Detection of Recurrent Laryngeal and Hypopharyngeal Cancers Post-radiotherapy. Indian J Otolaryngol Head Neck Surg 75, 753–759 (2023). https://doi.org/10.1007/s12070-022-03457-8

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  • DOI: https://doi.org/10.1007/s12070-022-03457-8

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