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Tumor volume as a prognostic factor of locally advanced laryngeal cancer

  • Head and Neck
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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 09 January 2021

Abstract

Purpose

The TNM tumor staging system is the most widely used for laryngeal cancer. However, in the same T stage, lesions with different primary tumor volumes (TV) can be found, impacting treatment outcomes.

Methods

145 patients with T3 and T4a laryngeal cancer, according to Union for International Cancer Control, who underwent surgical treatment from 2008 to 2017, were analyzed. TV measurements were collected and compared to different outcomes.

Results

The mean TV was 23.0 ± 16.4 cm3. A cutoff point for TV of 14.2 cm3 was established. Cumulative sample 5-year overall survival (OS) was 62.1%, while 5-years disease-free survival (DFS) was 65.5%. In univariate analysis, TV ≥ 14.2 cm3 was associated with a higher risk of distant metastases (p = 0.045), and worse rates of OS (p = 0.009) and DFS (p = 0.035). In multivariate analysis, TV was not an independent risk factor of worse DFS (p = 0.569) or OS (p = 0.094).

Conclusion

Primary lesion TV showed significant association, in univariate analysis, with worse rates of recurrence and survival in advanced laryngeal cancer undergoing surgical treatment and can be a promising prognostic for these patients.

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Funding

No financial support funds were used in this study.

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Authors and Affiliations

  1. Department of Head and Neck Surgery, Instituto Central, University of Sao Paulo Medical School, 8° andar. Cerqueira César, São Paulo, 05403-000, Brazil

    Natália Martins Magacho de Andrade, Rogério Aparecido Dedivitis & Leandro Luongo Matos

  2. Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil

    Daniel Marin Ramos & Leandro Luongo Matos

  3. Department of Radiology, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil

    Marcio Ricardo Taveira Garcia & Gustavo Gonçalves Conti

  4. Department of Head and Neck Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil

    Luiz Paulo Kowalski

Authors
  1. Natália Martins Magacho de Andrade
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  2. Rogério Aparecido Dedivitis
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  3. Daniel Marin Ramos
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  4. Leandro Luongo Matos
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  5. Marcio Ricardo Taveira Garcia
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  6. Gustavo Gonçalves Conti
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  7. Luiz Paulo Kowalski
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by NA, DR, RD and GC. The first draft of the manuscript was written by NA and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Natália Martins Magacho de Andrade.

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de Andrade, N.M.M., Dedivitis, R.A., Ramos, D.M. et al. Tumor volume as a prognostic factor of locally advanced laryngeal cancer. Eur Arch Otorhinolaryngol 278, 1627–1635 (2021). https://doi.org/10.1007/s00405-020-06438-1

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  • DOI: https://doi.org/10.1007/s00405-020-06438-1

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