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Oxidative stress values of tumor core, edge, and healthy thyroid tissue in thyroid masses

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Abstract

Purpose

Reactive oxygen radicals play an important role in tumor formation, progression, and invasion. In this study, the aim was to investigate the relationship between the oxidative stress values of tumor core, edge, and healthy thyroid tissue in thyroid tumors.

Methods

A total of 51 patients with thyroid tumor, 24-malignant, and 27-benign, were included in this study. Samples, measuring 5 × 5 × 5 mm, were taken from the tumor core, edge, and healthy thyroid tissue of the participants. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were examined. The oxidative stress values of core, edge, and healthy thyroid tissue of all tumors (n = 51) were compared according to the localization. The participants were divided into two groups as malignant (Group 1: Differentiated thyroid cancers) and benign (Group 2: Multinodular goiter). The groups were compared according to tissue localizations.

Results

The TOS value of tumor edge was significantly higher than the values of tumor core and healthy thyroid tissue. The OSI value of tumor edge was significantly higher than the values of tumor core and healthy thyroid tissue. There was no significant difference between Group 1 and Group 2 in terms of TAS, TOS, and OSI values of tumor core. The OSI values in tumor edge and healthy thyroid tissue were significantly higher in Group 1 than in Group 2. There was no significant difference between the groups in terms of TAS and TOS values of tumor edge and healthy thyroid tissue.

Conclusion

The oxidative stress values of tumor edge were significantly higher than the tumor core and healthy thyroid tissue values. The oxidative stress values of tumor edge and healthy thyroid tissue were significantly higher in malignant thyroid tumors compared to benign thyroid tumors.

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References

  1. Cabanillas ME, McFadden DG, Durante C (2016) Thyroid cancer. Lancet 388(10061):2783–2795

    Article  CAS  Google Scholar 

  2. Senthil N, Manoharan S (2004) Lipid peroxidation and antioxidants status in patients with papillary thyroid carcinoma in India. Asia Pac J ClinNutr 13:391–395

    CAS  Google Scholar 

  3. Wang D, Feng JF, Zeng P, Yang YH, Luo J, Yang YW (2011) Total oxidant/antioxidant status in sera of patients with thyroid cancers. Endocr Relat Cancer 18(6):773–782

    Article  CAS  Google Scholar 

  4. Genestra M (2007) Oxyl radicals, redox-sensitive signalling cascades, and antioxidants. Cell Signal 19(9):1807–1819

    Article  CAS  Google Scholar 

  5. Pizzino G, Irrera N, Cucinotta M et al (2017) Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev 2017:8416763

    PubMed  PubMed Central  Google Scholar 

  6. Uttara B, Singh AV, Zamboni P, Mahajan RT (2009) Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. CurrNeuropharmacol 7:65–74

    CAS  Google Scholar 

  7. Erdamar H, Demirci H, Yaman H et al (2008) The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med 46(7):1004–1010

    Article  CAS  Google Scholar 

  8. Karbownik-Lewińska M, Kokoszko-Bilska A (2012) Oxidative damage to macromolecules in the thyroid—experimental evidence. Thyroid Res 5(1):25

    Article  Google Scholar 

  9. Abiaka C, Al-Awadi F, Al-Sayer H et al (2001) Serum antioxidant and cholesterol levels in patients with different types of cancer. J Clin Lab Anal 15:324–330

    Article  CAS  Google Scholar 

  10. Akinci M, Kosova F, Cetin B et al (2008) Oxidant/antioxidant balance in patients with thyroid cancer. Acta CirurgicaBrasileira 23:551–554

    Google Scholar 

  11. Laatikainen LE, Castellone MD, Hebrant A et al (2010) Extracellular superoxide dismutase is a thyroid differentiation marker downregulated in cancer. Endocr Relat Cancer 17:785–796

    Article  CAS  Google Scholar 

  12. Lassoued S, Mseddi M, Mnif F et al (2010) A comparative study of the oxidative profile in Graves’ disease, Hashimoto’s thyroiditis, and papillary thyroid cancer. Biol Trace Elem Res 138:107–115

    Article  CAS  Google Scholar 

  13. Erdamar H, Cimen B, Gulcemal H et al (2010) Increased lipid peroxidation and impaired enzymatic antioxidant defense mechanism in thyroid tissue with multinodular goiter and papillary carcinoma. Clin Biochem 43:650–654

    Article  CAS  Google Scholar 

  14. Liu B, Kuang A, Huang R et al (2010) Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial. J Nucl Med 51:618–623

    Article  CAS  Google Scholar 

  15. Young O, Crotty T, O’Connell R, O’Sullivan J, Curran AJ (2010) Levels of oxidative damage and lipid peroxidation in thyroid neoplasia. Head Neck 32:750–756

    PubMed  Google Scholar 

  16. Stanley JA, Neelamohan R, Suthagar E et al (2016) Lipid peroxidation and antioxidants status in human malignant and non-malignant thyroid tumours. Hum ExpToxicol 35(6):585–597

    Article  CAS  Google Scholar 

  17. Terzioglu D, Teksoz S, Arikan AE, Uslu E, Yılmaz E, Eren B (2016) Relationship of hemoxygenase1 and prolidase enzyme activity with oxidative stress in papillary thyroid cancer. Hippokratia 20(1):55–59

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Ramli NSF, Mat Junit S, Leong NK, Razali N, Jayapalan JJ, Abdul Aziz A (2017) Analyses of antioxidant status and nucleotide alterations in genes encoding antioxidant enzymes in patients with benign and malignant thyroid disorders. PeerJ 5:e3365

    Article  Google Scholar 

  19. Privat-Maldonado A, Bengtson C, Razzokov J, Smits E, Bogaerts A (2019) Modifying the tumour microenvironment: challenges and future perspectives for anticancer plasma treatments. Cancers (Basel) 11(12):1920

    Article  CAS  Google Scholar 

  20. Zalewska-Ziob M, Adamek B, Kasperczyk J et al (2019) Activity of antioxidant enzymes in the tumor and adjacent noncancerous tissues of non-small-cell lung cancer. Oxid Med Cell Longev 2019:2901840

    Article  Google Scholar 

  21. Gaya-Bover A, Hernández-López R, Alorda-Clara M et al (2020) Antioxidant enzymes change in different non-metastatic stages in tumoral and peritumoral tissues of colorectal cancer. Int J Biochem Cell Biol 120:105698

    Article  CAS  Google Scholar 

  22. Hartree EF (1972) Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal Biochem 48(2):422–427

    Article  CAS  Google Scholar 

  23. Erel O (2005) A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38(12):1103–1111

    Article  CAS  Google Scholar 

  24. Erel O (2004) A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 37(2):112–119

    Article  CAS  Google Scholar 

  25. Maier J, van Steeg H, van Oostrom C et al (2006) Deoxyribonucleic acid damage and spontaneous mutagenesis in the thyroid gland of rats and mice. Endocrinology 147:3391–3397

    Article  CAS  Google Scholar 

  26. Lukosz M, Jakob S, Buchner N, Zschauer TC, Altschmied J, Haendeler J (2010) Nuclear redox signaling. Antioxid Redox Signal 12:713–742

    Article  CAS  Google Scholar 

  27. Holmström KM, Finkel T (2014) Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol 15:411–421

    Article  Google Scholar 

  28. Egeblad M, Nakasone ES, Werb Z (2010) Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 18:884–901

    Article  CAS  Google Scholar 

  29. Chung-man Ho J, Zheng S, Comhair SA, Farver C, Erzurum SC (2001) Differential expression of manganese superoxide dismutase and catalase in lung cancer. Cancer Res 61(23):8578–8585

    CAS  PubMed  Google Scholar 

  30. Santandreu FM, Brell M, Gene AH, Oliver J, Couce ME, Roca P (2008) Differences in mitochondrial function and anti-oxidant systems between regions of human glioma. Cell Physiol Biochem 22:757–768

    Article  CAS  Google Scholar 

  31. Chowdhury FN, Reisinger J, Gomez KE, Chimed TS, Thomas CM, Le PN (2019) Leading edge or tumor core: intratumor cancer stem cell niches in oral cavity squamous cell carcinoma and their association with stem cell function. Oral Oncol 98:118–124

    Article  CAS  Google Scholar 

  32. Guo W, Gao Y, Li N et al (2007) Exosomes: new players in cancer. Oncol Rep 38:665–675

    Article  Google Scholar 

  33. Sedelnikova OA, Redon CE, Dickey JS, Nakamura AJ, Georgakilas AG, Bonner WM (2010) Role of oxidatively induced DNA lesions in human pathogenesis. Mutat Res 704:152–159

    Article  CAS  Google Scholar 

  34. Karger S, Krause K, Engelhardt C et al (2012) Distinct pattern of oxidative DNA damage and DNA repair in follicular thyroid tumours. J MolEndocrinol 48:193–202

    Article  CAS  Google Scholar 

  35. Ameziane El Hassani R, Buffet C, Leboulleux S, Dupuy C (2019) Oxidative stress in thyroid carcinomas: biological and clinical significance. Endocr Relat Cancer 26(3):131–143

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey

    Remzi Dogan, Erol Senturk, Alper Yenigun, Ismail Celik, Fadlullah Aksoy & Orhan Ozturan

  2. Department of Internal Medicine, Bayrampasa State Hospital, Bayrampasa, Istanbul, Turkey

    Elif Ece Dogan

  3. Department of Biochemistry, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey

    Eray Metin Guler

Authors
  1. Remzi Dogan
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  2. Elif Ece Dogan
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  3. Eray Metin Guler
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Correspondence to Remzi Dogan.

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All authors declare that they have no conflict of interest.

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Clinical research for this study was approved by the local ethics committee.

Research involving human participants and/or animals

Human study.

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Dogan, R., Dogan, E.E., Guler, E.M. et al. Oxidative stress values of tumor core, edge, and healthy thyroid tissue in thyroid masses. Eur Arch Otorhinolaryngol 278, 2953–2960 (2021). https://doi.org/10.1007/s00405-020-06422-9

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  • DOI: https://doi.org/10.1007/s00405-020-06422-9

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