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A Comparative Study of the Oxidative Profile in Graves’ Disease, Hashimoto’s Thyroiditis, and Papillary Thyroid Cancer

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Abstract

The aim of this study was to evaluate and compare the oxidative profiles of three thyroid disorders: Graves’ disease (GD), Hashimoto thyroiditis (HT), and papillary thyroid cancer (PTC). Malondialdehyde levels (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were examined in the plasma of 52 patients (29 untreated HT, 16 untreated GD, and 7 PTC who underwent surgical therapy). Results were compared with those of 30 healthy controls and among the three groups of patients. The GD, HT, and PTC patients exhibited increased plasma MDA levels and SOD activities compared with the controls (p < 0.05, p < 0.05, and p < 0.001, respectively). CAT activities significantly increased only for the PTC and HT patients (p < 0.001 and p < 0.05, respectively), whereas GPx activities significantly decreased only in the GD and PTC (p < 0.05 and p < 0.01, respectively). The comparison among the three groups of patients has shown increased MDA level and SOD activity for the PTC patients as compared to the GD patients (p < 0.01 and p < 0.001, respectively). Compared with HT, PTC patients exhibited significant higher MDA level, SOD, and CAT activities and a significant lower GPx activity (p < 0.01, p < 0.001, p < 0.05, and p < 0.05, respectively). No significant discrepancies were noted between the GD and HT patients. Our results have clearly shown an oxidative profile that is highly disturbed for the PTC patients as compared to those of autoimmune disorders. Future studies are needed to determine whether or not the oxidative stress has a prognostic value in this pathology.

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Abbreviations

CAT:

Catalase

FT4:

Free thyroxin

FT3:

Free tri-iodothyronin

GPx:

Glutathione peroxidase

GSH:

Glutathione

GD:

Grave’s disease

HT:

Hashimoto thyroiditis

PTC:

Papillary thyroid cancer

MDA:

Malondialdehyde

SOD:

Superoxide dismutase

TBARs:

Thiobarbituric acid reactive species

TPO:

Thyroperoxidase

TG:

Thyroglobulin

T4:

Thyroxin

T3:

Tri-iodothyronin

ROS:

Reactive oxygen species

TSH:

Thyroid-stimulating hormone

Anti-TPO:

Antibody anti-thyroperoxidase

Anti-TG:

Antibody anti-thyroglobulin

TSH-R:

Thyroid-stimulating hormone receptor

TSH:

Thyroid-stimulating hormone

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Authors and Affiliations

  1. Unité de Biotechnologie et Pathologies, Institut Supérieur de Biotechnologie de Sfax, route de Soukra km4, B.P.261, 3038, Sfax, Tunisia

    Saloua Lassoued, Malek Mseddi & Hamadi Attia

  2. Service d’endocrinologie interne et externe, CHU Hedi Chaker, Sfax, Tunisia

    Fatma Mnif & Mohamed Abid

  3. Service de médecine nucléaire, CHU Habib Bourguiba, Sfax, Tunisia

    Fadhel Guermazi

  4. Laboratoire d’immunologie CHU Habib Bourguiba, Sfax, Tunisia

    Hatem Masmoudi

  5. Unité de Physiologie Animale, Faculté des Sciences de Sfax, Sfax, Tunisia

    Abdelfatteh El Feki

Authors
  1. Saloua Lassoued
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  2. Malek Mseddi
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  3. Fatma Mnif
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  4. Mohamed Abid
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  5. Fadhel Guermazi
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  6. Hatem Masmoudi
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  7. Abdelfatteh El Feki
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  8. Hamadi Attia
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Corresponding author

Correspondence to Saloua Lassoued.

Additional information

Saloua Lassoued and Malek Mseddi have equally contributed in this paper.

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Lassoued, S., Mseddi, M., Mnif, F. et al. A Comparative Study of the Oxidative Profile in Graves’ Disease, Hashimoto’s Thyroiditis, and Papillary Thyroid Cancer. Biol Trace Elem Res 138, 107–115 (2010). https://doi.org/10.1007/s12011-010-8625-1

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  • DOI: https://doi.org/10.1007/s12011-010-8625-1

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