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Association of CD14 gene -159C/T polymorphism with allergic rhinitis risk: a meta-analysis

  • Rhinology
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Abstract

The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to allergic rhinitis (AR), but results were conflicting. The aim of this study is to investigate the association between the CD14-159C/T polymorphism and the risk of AR. All eligible case–control studies published up to July 2013 were identified by searching PubMed, Web of Science and CNKI. Pooled odds ratio with 95 % confidence interval (95 % CI) was used to access the strength of this association in fixed- or random-effects model. A total of seven case–control studies, including 887 cases and 889 controls, were selected. Overall, no significant association between the CD14-159C/T polymorphism and AR risk was found. Besides, stratified analysis with ethnicity and source of control also indicated that no significant association between CD14-159C/T and the risk of AR under all for genetic model was observed. This meta-analysis indicated that the CD14-159C/T polymorphism is not associated with AR risk.

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References

  1. Kay AB (2001) Allergy and allergic diseases. Second of two parts. N Engl J Med 344:109–113

    Article  CAS  PubMed  Google Scholar 

  2. Meltzer EO, Blaiss MS, Derebery MJ et al (2009) Burden of allergic rhinitis: results from the pediatric allergies in America survey. J Allergy Clin Immunol 124:S43–S70

    Article  PubMed  Google Scholar 

  3. Davila I, Mjullol J, Ferrer M et al (2009) Genetic aspects of allergic rhinitis. J Investig Allergol Clin Immunol 19:25–31

    CAS  PubMed  Google Scholar 

  4. Wallace DV, Dykewicz MS, Bernstein DI et al (2008) The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 122:S1–S84

    Article  PubMed  Google Scholar 

  5. Vercelli D (2008) Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 8:169–182

    Article  CAS  PubMed  Google Scholar 

  6. Bunyavanich S, Shargorodsky J, Celedón JC (2011) A meta-analysis of Th2 pathway genetic variants and risk for allergic rhinitis. Pediatr Allergy Immunol 22:378–387

    Article  PubMed Central  PubMed  Google Scholar 

  7. Wang DY (2011) Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population. Asia Pac Allergy 1:152–156

    Article  PubMed Central  Google Scholar 

  8. Ying X, Zhang R, Yu S et al (2012) Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: a meta-analysis based on 1,411 cases and 3,169 controls. Gene 506:179–183

    Article  CAS  PubMed  Google Scholar 

  9. Ying XJ, Zhao SW, Wang GL et al (2013) Association of interleukin-13 SNP rs20541 with allergic rhinitis risk: a meta-analysis. Gene 521:222–226

    Article  CAS  PubMed  Google Scholar 

  10. Ulevitch RJ, Tobias PS (1995) Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 13:437–457

    Article  CAS  PubMed  Google Scholar 

  11. Leung TF, Tang NL, Sung YM et al (2003) The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children. Pediatr Allergy Immunol 14:255–260

    Article  PubMed  Google Scholar 

  12. Han D, She W, Zhang L (2010) Association of the CD14 gene polymorphism C-159T with allergic rhinitis. Am J Rhinol Allergy 24:e1–e3

    Article  PubMed  Google Scholar 

  13. Hu HF (2010) Study on the relationship between polymorphism of CD14 gene and allergic rhinitis in Xinjiang Uygurs and Hans. Xinjiang Yike Daxue, Xinjiang (Article in Chinese)

    Google Scholar 

  14. Kang HJ, Choi YM, Chae SW et al (2006) Polymorphism of the CD14 gene in perennial allergic rhinitis. Int J Pediatr Otorhinolaryngol 70:2081–2085

    Article  PubMed  Google Scholar 

  15. Lu HM, Li ZM, Fang CF et al (2006) The correlation of ACE gene polymorphism and -159C/T polymorphism of CD14 gene promoter with allergic rhinitis. Tianjin Med J 34:860–862 (Article in Chinese)

    CAS  Google Scholar 

  16. Micheal S, Minhas K, Ishaque M et al (2011) Promoter polymorphisms of the CD14 gene are associated with atopy in Pakistani adults. J Investig Allergol Clin Immunol 21:394–397

    CAS  PubMed  Google Scholar 

  17. Sengler C, Haider A, Sommerfeld C et al (2003) Evaluation of the CD14 C-159 T polymorphism in the German multicenter allergy study cohort. Clin Exp Allergy 33:166–169

    Article  CAS  PubMed  Google Scholar 

  18. Takeuchi K, Suzuki S, Yagawa M et al (2005) A CD14 gene polymorphism is associated with the IgE level for Dermatophagoides pteronyssinus. Acta Otolaryngol 125:966–971

    Article  CAS  PubMed  Google Scholar 

  19. Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127:820–826

    Article  CAS  PubMed  Google Scholar 

  20. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Can Inst 22:719–748

    CAS  Google Scholar 

  21. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

    Article  CAS  PubMed  Google Scholar 

  22. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101

    Article  CAS  PubMed  Google Scholar 

  23. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Baldini M, Lohman IC, Halonen M et al (1999) A polymorphism in the 5’ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 20:976–983

    Article  CAS  PubMed  Google Scholar 

  25. Lazarus R, Vercelli D, Palmer LJ et al (2002) Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol Rev 190:9–25

    Article  CAS  PubMed  Google Scholar 

  26. LeVan TD, Bloom JW, Bailey TJ et al (2001) A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 167:5838–5844

    Article  CAS  PubMed  Google Scholar 

  27. Majello B, De Luca P, Lania L (1997) Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J Biol Chem 272:4021–4026

    Article  CAS  PubMed  Google Scholar 

  28. Gao PS, Mao XQ, Baldini M et al (1999) Serum total IgE levels and CD14 on chromosome 5q31. Clin Genet 56:164–165

    Article  CAS  PubMed  Google Scholar 

  29. Vercelli D, Baldini M, Stern D et al (2001) CD14: a bridge between innate immunity and adaptive IgE responses. J Endotoxin Res 7:45–48

    Article  CAS  PubMed  Google Scholar 

  30. Koppelman GH, Reijmerink NE, Stine CO et al (2001) Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respir Crit Care Med 163:965–969

    Article  CAS  PubMed  Google Scholar 

  31. Buckova D, Holla LI, Schuller M et al (2003) Two CD14 promoter polymorphisms and atopic phenotypes in Czech patients with IgE-mediated allergy. Allergy 58:1023–1026

    Article  CAS  PubMed  Google Scholar 

  32. Zhang Y, Tian C, Zhang J et al (2011) The -159C/T polymorphism in the CD14 gene and the risk of asthma: a meta-analysis. Immunogenetics 63:23–32

    Article  CAS  PubMed  Google Scholar 

  33. Zheng J, Hou T, Gao L et al (2013) Association between CD14 gene polymorphism and periodontitis: a meta-analysis. Crit Rev Eukaryot Gene Expr 23:115–123

    Article  CAS  PubMed  Google Scholar 

  34. Wang Z, Hu J, Fan R et al (2012) Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis. PLoS One 7:e45144

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  35. Zeng T, Zhang CL, Han XY et al (2013) Association between CD14-159C > T polymorphisms and the risk for alcoholic liver disease: a meta-analysis. Eur J Gastroenterol Hepatol. doi:10.1097/MEG.0b013e3283612ff1 PMID: 23587862

    Google Scholar 

  36. Vazgiourakis VM, Zervou MI, Choulaki C et al (2011) A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis. Ann Rheum Dis 70:2184–2190

    Article  CAS  PubMed  Google Scholar 

  37. Areeshi M, Mandal RK, Panda AK et al (2013) CD14-159 C > T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis. PLoS One 8:e64747

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  38. Pu H, Yin J, Wu Y et al (2013) The association between CD14 gene C-260T polymorphism and coronary heart disease risk: a meta-analysis. Mol Biol Rep 40:4001–4008

    Article  CAS  PubMed  Google Scholar 

  39. Banerjee I (2009) CD14 C260T promoter polymorphism and the risk of cerebrovascular diseases: a meta-analysis. J Appl Genet 50:153–157

    Article  CAS  PubMed  Google Scholar 

  40. Zhang HF, Zhong BL, Zhu WL et al (2009) CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis. Genet Med 11:403–408

    Article  CAS  PubMed  Google Scholar 

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Otolaryngology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China

    Yu Xu

  2. Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China

    Jun Wang

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  1. Yu Xu
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  2. Jun Wang
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Correspondence to Yu Xu.

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Xu, Y., Wang, J. Association of CD14 gene -159C/T polymorphism with allergic rhinitis risk: a meta-analysis. Eur Arch Otorhinolaryngol 271, 1601–1607 (2014). https://doi.org/10.1007/s00405-013-2793-5

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  • DOI: https://doi.org/10.1007/s00405-013-2793-5

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