Abstract
In view of the controversies surrounding the angiotensin-converting enzyme (ACE)–allergic rhinitis (AR) association, a systematic review and meta-analysis of the ACE genetic association studies of AR was performed in Chinese populations. PubMed, Springer Link, OvidSP, Chinese biomedical database, Chinese national knowledge infrastructure, Chinese VIP and Wanfang databases were searched for related studies. A total of 4 studies including 415 AR patients and 309 controls were involved in this meta-analysis. Overall, significant association was found between ACE I/D polymorphism and AR risk when all studies in Chinese populations pooled into the meta-analysis (allele, OR 1.50, 95 % CI 1.19–1.90; homozygous, OR 2.59, 95 % CI 1.52–4.41, recessive, OR 2.05, 95 % CI 1.27–3.32). In the subgroup analysis by ethnicity, ACE I/D polymorphism was associated with significant elevated risks of AR in Chinese Han under homozygous and recessive models (homozygous, OR 4.36, 95 % CI 1.76–10.82, recessive, OR 2.51, 95 % CI 1.18–5.34). In conclusion, this meta-analysis provides the evidence that ACE I/D polymorphism may contribute to the AR development in Chinese populations and studies with large sample size and wider spectrum of population are warranted to verify this finding.
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References
Calamelli E, Ricci G, Pession A (2012) Recent advances in diagnosis and therapy of allergic rhinitis and asthma in child-hood. Eur Ann Allergy Clin Immunol 44:215–224
Qiu S, Du Y, Duan X et al (2012) B cell immunity in allergic nasal mucosa induces T helper 2 cell differentiation. J Clin Immunol 32:886–895
Small M, Piercy J, Demoly P et al (2013) Burden of illness and quality of life in patients being treated for seasonal allergic rhinitis: a cohort survey. Clin Transl Allergy 3:33
Szilasi M, Gálffy G, Fónay K et al (2012) A survey of the burden of allergic rhinitis in Hungary from a specialist’s perspective. Multidiscip Respir Med 7:49
Bousquet J, Khaltaev N, Cruz AA et al (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2 LEN and AllerGen). Allergy 63:8–160
Bauchau V, Durham SR (2004) Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 24:758–764
Nathan RA, Meltzer EO, Derebery J et al (2008) The prevalence of nasal symptoms attributed to allergies in the United States: findings from the burden of rhinitis in an America survey. Allergy Asthma Proc 29:600–608
Zhang L, Han D, Huang D et al (2009) Prevalence of self-reported allergic rhinitis in eleven major cities in China. Int Arch Allergy Immunol 149:47–57
Zhang YM, Zhang J, Liu SL et al (2013) Prevalence and associated risk factors of allergic rhinitis in preschool children in Beijing. Laryngoscope 123:28–35
Dávila I, Mullol J, Ferrer M et al (2009) Genetic aspects of allergic rhinitis. J Investig Allergol Clin Immunol 19:25–31
Wang QJ, Fan SG, Lu JP et al (2005) Study on the Association between ACE gene polymorphism and allergic rhinitis. J Mod Clin Med Bioeng 11:437–438 (in Chinese)
Lu HM, Li ZM, Fang CF et al (2006) The correlation of ACE gene polymorphism and −159C/T polymorphism of CDl4 gene promoter with allergic rhinitis. Tianjin Med J 34:860–862 (in Chinese)
Ku MS, Lue KH, Li C et al (2006) Association between angiotensin-converting enzyme gene polymorphism and childhood allergic rhinitis in Taiwan. J Microbiol Immunol Infect 39:297–301
Lue KH, Ku MS, Li C et al (2006) ACE gene polymorphism might disclose why some Taiwanese children with allergic rhinitis develop asthma symptoms but others do not. Pediatr Allergy Immunol 17:508–513
Holla L, Vasku A, Znojil V et al (1999) Association of 3 gene polymorphisms with atopic diseases. J Allergy Clin Immunol 103:702–708
Kim JJ, Kim HJ, Lee IK et al (2004) Association between polymorphisms of the angiotensin-converting enzyme and angiotensinogen genes and allergic rhinitis in a Korean population. Ann Otol Rhinol Laryngol 113:97–302
Avis M (1994) Reading research critically. II. An introduction to appraisal: assessing the evidence. J Clin Nurs 3:271–277
Lin H, Lin D, Zheng CQ (2013) Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: Evidence from 1410 subjects. J Renin Angiotensin Aldosterone Syst. doi:10.1177/1470320313502107
Grammatikos AP (2008) The genetic and environmental basis of atopic diseases. Ann Med 40:482–495
de Wang Y (2011) Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population. Asia Pac Allergy 1:152–156
Yu SQ (2003) A review on genetic study for allergic rhinitis. Foreign Med Sci (Section of Otolary Ngology) 27:71–75 (in Chinese)
Brozek JL, Bousquet J, Baena-Cagnani CE et al (2010) Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 126:466–476
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Huang, RF., Dong, P., Zhang, TZ. et al. Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to allergic rhinitis in Chinese populations: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 273, 277–283 (2016). https://doi.org/10.1007/s00405-014-3350-6
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DOI: https://doi.org/10.1007/s00405-014-3350-6