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Quantitative assessment of the association between GSTM1 null genotype and laryngeal cancer risk

  • Laryngology
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Abstract

Previous studies investigating the association between glutathione S-transferase M1 (GSTM1) null genotype and laryngeal cancer risk reported controversial results. Thus, a meta-analysis was performed to clarify the effect of GSTM1 null genotype on laryngeal cancer risk. A literature search was performed for all possible studies. We estimated summary odd ratio (OR) with its 95 % confidence interval (95 % CI) to assess the association. Subgroup analyses were performed by ethnicity or the sample size. 24 individual case–control studies involving a total of 2,809 laryngeal cancer cases and 4,478 controls were finally included into this meta-analysis. Meta-analyses of total 24 studies showed the GSTM1 null genotype was significantly associated with increased laryngeal cancer risk (random-effects OR = 1.44, 95 % CI 1.19–1.73, P < 0.001). Subgroup analyses by ethnicity showed that the GSTM1 null genotype was associated with increased laryngeal cancer risk in both Caucasians (fixed-effects OR = 1.17, 95 % CI 1.04–1.33, P = 0.012) and Asians (random-effects OR = 1.89, 95 % CI 1.28–2.77, P = 0.001). Also, subgroup analyses by sample size also further identified this association above. The cumulative meta-analyses showed a trend of more obvious association between GSTM1 null genotype and increased risk of laryngeal cancer as information accumulated by year. Meta-analysis of available data suggests that GSTM1 null genotype contributes to increased laryngeal cancer risk in both Caucasians and East Asians.

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  1. Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xue Fu Road, Harbin, 150081, China

    Hui Xiao, Minghua Li, Linli Tian, Bin Zha, Ming Liu & Hongchao Yao

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  1. Hui Xiao
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  2. Minghua Li
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Correspondence to Hongchao Yao.

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H. Xiao and M. Li contributed equally to this work.

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Xiao, H., Li, M., Tian, L. et al. Quantitative assessment of the association between GSTM1 null genotype and laryngeal cancer risk. Eur Arch Otorhinolaryngol 270, 615–622 (2013). https://doi.org/10.1007/s00405-012-2148-7

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