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Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses

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Abstract

Purpose

Previous evidence implicates CYP1A1 and GSTM1 polymorphisms as risk factors for various cancers. A number of studies have been devoted to the association of CYP1A1 or GSTM1 polymorphism with susceptibility to laryngeal carcinoma, with the results inconsistent and inconclusive. The aim of the present study was to assess the possible associations of laryngeal cancer risk with CYP1A1 genetic variation and GSTM1 null genotype respectively.

Methods

The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications, then the extracted data were further analyzed using systematic meta-analyses.

Results

The results showed that the overall odds ratio (OR) was 1.32 (95% CI = 1.08–1.61) for CYP1A1 Mspl polymorphism. Using subgroup analysis, the pooled ORs were 1.38 (95% CI = 0.98–1.95) in Asians and 1.29 (95% CI = 1.01–1.65) in Caucasians. For CYP1A1 exon7 polymorphism, the overall OR was 1.38 (95% CI = 0.98–1.95). The overall OR was 1.24 (95% CI = 1.03–1.49) for GSTM1 polymorphism and the pooled ORs were 1.36 (95% CI = 0.75–2.48) in Asians, 1.16 (95% CI = 0.94–1.44) in Caucasians and 1.52 (95% CI = 1.05–2.19) in Turkey population.

Conclusions

The data suggest CPY1A1 MspI polymorphism as a risk factor for laryngeal cancer in Caucasians but not in Asians. However, the results suggest a marked correlation of GSTM1 polymorphism with laryngeal cancer risk in Turkey population but not Caucasians and Asians.

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Abbreviations

CYP1A1:

Cytochrome P450 1A1

GSTM1:

Glutathione S-transferase M1

ORs:

Odds ratios

CIs:

Confidence intervals

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Acknowledgments

This work was partially supported by the postgraduate funds of Third Military Medical University (2005256), the National Natural Science Foundation of China (30800506) and Natural Science Foundation of Chongqing (CSTC, 2008BB5124). Moreover, we take this opportunity to thank the anonymous reviewers and editors for their constructive comments that may prove helpful in our future research.

Conflict of interest statement

None.

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Authors and Affiliations

  1. Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038, Chongqing, China

    Wen-Lei Zhuo, Bo Zhu & Zheng-Tang Chen

  2. Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, China

    Yan Wang

  3. Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China

    Xian-Lu Zhuo

  4. College of Food Science and Nutritional Engineering, China Agriculture University, Beijing, China

    Yi Zhu

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  1. Wen-Lei Zhuo
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  2. Yan Wang
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  4. Bo Zhu
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  5. Yi Zhu
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Correspondence to Xian-Lu Zhuo or Zheng-Tang Chen.

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The author Xian-Lu Zhuo works at Guiyang Medical College.

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Zhuo, WL., Wang, Y., Zhuo, XL. et al. Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses. J Cancer Res Clin Oncol 135, 1081–1090 (2009). https://doi.org/10.1007/s00432-009-0548-x

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  • DOI: https://doi.org/10.1007/s00432-009-0548-x

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