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Cyclooxygenase 1 and 2 expressions in the human thyroid gland

  • Head and Neck Oncology
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Abstract

We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

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Authors and Affiliations

  1. Department of Otolaryngology and Head and Neck Surgery, Korea University College of Medicine, Guro Hospital, 97 Gurodong-gil Guro-gu, 152-703, Seoul, Korea

    Heung-Man Lee, Seung-Kuk Baek, Soon-Young Kwon, Kwang-Yoon Jung, Sung-Won Chae, Soon-Jae Hwang & Jeong-Soo Woo

  2. Department of Preventive Medicine, Korea University College of Medicine, Guro Hospital, Seoul, Korea

    June-Young Lee

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  1. Heung-Man Lee
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  2. Seung-Kuk Baek
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  7. Jeong-Soo Woo
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Correspondence to Jeong-Soo Woo.

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Lee, HM., Baek, SK., Kwon, SY. et al. Cyclooxygenase 1 and 2 expressions in the human thyroid gland. Eur Arch Otorhinolaryngol 263, 199–204 (2006). https://doi.org/10.1007/s00405-005-0999-x

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  • DOI: https://doi.org/10.1007/s00405-005-0999-x

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