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Biocompatibility testing of novel multifunctional polymeric biomaterials for tissue engineering applications in head and neck surgery: an overview

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Abstract

Biomaterial research and tissue engineering are rapidly growing scientific fields that need an interdisciplinary approach where clinicians should be included from the onset. Biocompatibility testing in vitro and in vivo comprise the agarose-overlay test, the MTT test, direct cell seeding tests and the chorioallantoic membrane test for angiogenic effects, among others. Molecular biology techniques such as real-time polymerase chain reaction and microarray technology facilitate the investigation of tissue integration into biomaterials on a cellular and molecular level. The physicochemical characterization of biomaterials is conducted using such methods as X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Excellent biocompatibility and biofunctionality were demonstrated for a series of recently developed multifunctional biodegradable, polymeric biomaterials both in vitro and in vivo. Novel, multifunctional polymeric biomaterials offer a highly specific adjustment to the physiological, anatomical and surgical requirements and can thereby facilitate new therapeutic options in head and neck surgery.

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Acknowledgements

This work was supported by grants from the Deutsche Forschungsgemeinschaft (RI 1057/1-1) to Dorothee Rickert and from BMBF BioFuture (0311867) to Andreas Lendlein.

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Authors and Affiliations

  1. Department of Otolaryngology and Head and Neck Surgery, University of Ulm, Prittwitzstr. 43, 89075, Ulm, Germany

    Dorothee Rickert

  2. Central Institute for Biomedical Engineering, Department for Biomaterials, University of Ulm, Ulm, Germany

    Ilka Peters & Ralf-Peter Franke

  3. Forschungszentrum Karlsruhe, Institute of Biological Interface, Karlsruhe, Germany

    Ralf-Peter Franke

  4. GKSS Forschungszentrum Geestacht GmbH, Institute of Chemistry, Teltow, Germany

    Andreas Lendlein

  5. Department of Surgery and The Vascular Biology Program, Harvard Medical School Children’s Hospital, Boston, MA, USA

    Marsha A. Moses

Authors
  1. Dorothee Rickert
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  2. Andreas Lendlein
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  3. Ilka Peters
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  4. Marsha A. Moses
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  5. Ralf-Peter Franke
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Correspondence to Dorothee Rickert.

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Rickert, D., Lendlein, A., Peters, I. et al. Biocompatibility testing of novel multifunctional polymeric biomaterials for tissue engineering applications in head and neck surgery: an overview. Eur Arch Otorhinolaryngol 263, 215–222 (2006). https://doi.org/10.1007/s00405-005-0950-1

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  • DOI: https://doi.org/10.1007/s00405-005-0950-1

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