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Endothelial nitric oxide synthase/soluble guanylate cyclase system in human nasal polyps

  • Rhinology
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European Archives of Oto-Rhino-Laryngology and Head & Neck Aims and scope Submit manuscript

Abstract

The aim of our study was to analyze the level of expression of the endothelial nitric oxide synthase (eNOS)/soluble guanylate cyclase (sGC) system in nasal polyps and control nasal mucosae. The study was performed in polyps from 15 patients and nasal mucosae from 11 subjects operated on the nasal septum (control group). The expression of endothelial nitric oxide synthase (eNOS) and soluble guanylate cyclase (sGC) was determined in nasal mucosae. Western blot analysis demonstrated that eNOS protein was overexpressed in the nasal polyps with respect to control nasal mucosae. Immunohistochemistry also demonstrated that the vascular endothelium of nasal polyps contained higher amounts of eNOS protein than control nasal mucosae. Moreover, the β1 subunit of sGC was also overexpressed in the nasal polyps, which was associated with an increased content of cyclic GMP in the nasal polyps with respect to nasal control mucosae. In human nasal polyposis, there is an overexpression of the eNOS/sGC system. Further studies are needed to assess whether this overexpression is involved in the genesis of nasal polyposis.

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Acknowledgements

This work was supported by a grant from Bayer Laboratores. S. Alonso-Orgaz is a fellow of Fundación Conchita Rábago de Fundación Jiménez Díaz. C. Carrasco is a fellow of Fondo de Investigaciones Sanitarias de la Seguridad Social (PI 020347).

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Fundación Jiménez Díaz, Madrid, Spain

    Paloma Escobar, Francisco J Márquez, José Fortes & Carlos Cenjor

  2. Cardiovascular Institute, Hospital Clínico San Carlos, 28040, Madrid, Spain

    Carolina Carrasco, Sergio Alonso-Orgaz & Antonio López-Farré

Authors
  1. Paloma Escobar
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  2. Francisco J Márquez
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  3. Carolina Carrasco
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  4. Sergio Alonso-Orgaz
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  5. José Fortes
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  6. Carlos Cenjor
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  7. Antonio López-Farré
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Corresponding author

Correspondence to Antonio López-Farré.

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Escobar, P., Márquez, F.J., Carrasco, C. et al. Endothelial nitric oxide synthase/soluble guanylate cyclase system in human nasal polyps. Eur Arch Otorhinolaryngol 262, 512–516 (2005). https://doi.org/10.1007/s00405-004-0857-2

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  • DOI: https://doi.org/10.1007/s00405-004-0857-2

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