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Effects of intrauterine device use on attack frequency and severity ın woman of reproductive age with familial Mediterranean fever

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Aim

Familial Mediterranean fever (FMF) is the most common inherited autoinflammatory disease in the world. There are known triggers to initiate an FMF attack, yet potential effects of intrauterine devices (IUD) in women of reproductive age have not been evaluated before.

Method

Consecutive female patients with FMF who ever used IUD over the age of 18 were enrolled. Female patients with FMF were sub grouped according to the type of IUD they use. FMF attack frequency, severity, duration, presence of dysmenorrhea, severity of dysmenorrhea, having attacks during menstruation before and after IUD use were questioned. Demographic and clinical data were collected from hospital database.

Results

When all patients with IUD use were evaluated, it was found that the frequency of attacks increased after IUD insertion at 3rd and 12th months (median [min–max] attack frequency at 3rd month, 1 (0–3) vs 1 (0–6), p = 0.002, median [min–max] attack frequency at 12th month, 2 (0–12) vs 3.5 (0–18), p = 0.028). Attack severity measured by VAS pain was also significantly increased. Attack duration and menstrual pain was similar before and after IUD use. Attack frequency at 3rd and 12th months, attack severity and menstrual pain was all increased significantly in Cu-IUD users, whereas none of these parameters deteriorated in LNG-IUD group.

Conclusion

IUD use, especially Cu-IUD, may increase the frequency and severity of attacks in female patients with FMF. Clinicians may benefit from considering LGN-IUD if IUDs are preferred as contraception in women of childbearing age with FMF.

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Data availability

Data are available from the authors upon request.

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Acknowledgements

This research received no specific grant from any funding agency.

Funding

There is no funding. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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Authors and Affiliations

  1. Department of Rheumatology, Ankara Gaziler Physical Therapy and Rehabilitation Training and Research Hospital, Ankara, 06800, Turkey

    Bahar Özdemir Ulusoy

  2. Department of Rheumatology, Ankara City Hospital, Ankara, Turkey

    Serdar Can Güven, Hakan Babaoğlu, Berkan Armağan, Esra Kayacan Erdoğan, Yüksel Maraş, Kevser Orhan, Rezan Koçak Ulucaköy, Ebru Atalar & Ahmet Omma

  3. Division of Perinatology, Department of Gynecology and Obstetrics, Ankara Etlik City Hospital, Ankara, Turkey

    Can Ozan Ulusoy

  4. Division of Rheumatology, Department of Internal Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey

    İsmail Doğan, Orhan Küçükşahin & Şükran Erten

Authors
  1. Bahar Özdemir Ulusoy
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  2. Serdar Can Güven
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Contributions

ÖUB: protocol development, data collection and management, manuscript writing, SCG: protocol development, data analysis, manuscript editing, HB: data analysis, manuscript writing, COU: data analysis, manuscript writing, BA: data collection and management, EKE: data collection and management, YM:data collection and management, İD: data collection and management, KO: data collection and management, RKU: data collection and management, EA: data collection and management, AO: protocol development, manuscript editing, OK: protocol development, manuscript editing, ŞE: protocol development, manuscript editing.

Corresponding author

Correspondence to Bahar Özdemir Ulusoy.

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No potential conflict of interest was reported by the author(s).

Ethical approval

The study was approved by the Ankara City Hospital Ethics Committee (number: E1-22-3032) and was performed according to the principles of the Declaration of Helsinki.

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Özdemir Ulusoy, B., Güven, S.C., Babaoğlu, H. et al. Effects of intrauterine device use on attack frequency and severity ın woman of reproductive age with familial Mediterranean fever. Arch Gynecol Obstet 309, 2041–2046 (2024). https://doi.org/10.1007/s00404-024-07413-5

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