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The role of systemic immune inflammation index in predicting treatment success in tuboovarian abscesses

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to determine the predictability of the systemic immune inflammation index (SII) on the response to medical treatment in tubo-ovarian abscess (TOA).

Methods

296 patients with TOA in a tertiary center were enrolled in the study. Patients were divided into two groups: Group1 (n  =  165) included patients in whom medical treatment was successful, and Group2 (n  =  131) included patients in whom surgery was required. Demographic, sonographic and laboratory findings were compared between groups. SII was calculated using peripheral blood parameters [SII  =  (platelets ∗ neutrophils)/lymphocytes].

Results

Age, BMI, gravida, parity, smoking and menopausal status, CRP levels of patients were similar in both groups (p  >  0.05). Mass size (4.398 ± 0.306 vs 7.683 ± 0.689, p  <  0.001), white blood cell (WBC) (8685.08 ± 3981.98 vs 9994.35 ± 4468.024, p = 0.008), Hb (12.18 ± 1.65 vs 11.68 ± 1.65, p = 0.010), platelet to lymphocyte ratio (PLR) (151.26 ± 74.83 vs 230.77 ± 140.25, p < 0.001), neutrophil to lymphocyte ratio (NLR) (4.21 ± 3.27 vs 6.07 ± 6.6, p  =  0.003), monocyte to lymphocyte ratio (MLR) (0.300 ± 0.177 vs 0.346 ± 0.203, p = 0.041) and SII (1014.18 ± 781.71 vs 2094.088 ± 2117.58, p < 0.001) were statistically higher in group 2. ROC Analysis was used to determine the predictability of the variables and PLR (AUC = 0.718, p  <  0.001), NLR (AUC = 0.593, p  =  0.593), MLR (AUC = 0.576, p  =  0.024), SII (AUC  =  0.723, p  <  0.001) and size of mass (AUC = 0.670, p  <  0.001) were found to be significant. The SII, size of mass and bilateral involvement of adnexa were found to be the strongest prognostic factors for surgical intervention (OR:1.004 (1.002–1.005), OR:1.018 (1.010–1.027), OR:3.397 (1.338–8.627); p  <  0.001, p  <  0.001, p  =  0.010 resspectively).

Conclusion

SII, size of mass and bilaterality can be used to predict medical treatment success in patients with TOA.

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Data availability

The data supporting the findings of this study are available upon reasonable request from the corresponding author.

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Funding

The authors declared that this study receives no financial support.

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Authors and Affiliations

  1. Department of Gynecologic Oncology, Ankara Etlik Zubeyde Hanım Women’s Health Training and Research Hospital, Ankara, Turkey

    Vakkas Korkmaz

  2. Ankara Etlik Zubeyde Hanım Women’s Health Training and Research Hospital, 06010, Ankara, Turkey

    Caner Kose, Busra Korpe & Yaprak Engin Ustun

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  1. Caner Kose
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  2. Busra Korpe
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Contributions

Surgical and Medical Practices: CK, BK, VK. Concept: VK, YEU. Design: VK, YEU. Data Collection or Processing: CK, BK. Analysis or Interpretation: CK, VK. Literature Search: CK, BK. Writing: CK, BK.

Corresponding author

Correspondence to Caner Kose.

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No conflict of interest is declared by the authors.

Ethical approval

The study design was approved by the instutional research ethics committee (approval number: 06/11).

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Written informed consent was obtained from all participants.

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Written informed consent was obtained from all participants.

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Kose, C., Korpe, B., Korkmaz, V. et al. The role of systemic immune inflammation index in predicting treatment success in tuboovarian abscesses. Arch Gynecol Obstet 308, 1313–1319 (2023). https://doi.org/10.1007/s00404-023-07107-4

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  • DOI: https://doi.org/10.1007/s00404-023-07107-4

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