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Oxidative stress and antioxidant status in threatened preterm labor

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study was the evaluation of total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and superoxide dismutase (SOD) levels in women with threatened preterm labor (TPL) and also to compare the levels of these oxidative stress biomarkers of TPL pregnancies that had preterm and term deliveries.

Methods

This case–control study was conducted on 46 patients diagnosed with TPL and 47 healthy pregnant women matched for gestational age. Patients with threatened preterm labor were divided into two groups: true preterm birth (TPB) group (n = 16) and false preterm birth (FPB) group (n = 30) groups. Maternal serum SOD, TOS and TAS levels were measured by a spectrophotometric method using a commertial kit. OSI level for each patient was calculated by using the formula: (TOS (μmol·H2O2·equiv/L) × 100)/(TAS (μmol·Trolox·equiv/L)).

Results

The mean TAS levels of the TPB and FPB groups were significantly lower than those of the control group (0.96 ± 0.3 vs 1.36 ± 0.34, p1 < 0.001; 0.97 ± 0.22 vs 1.36 ± 0.34, p2 < 0.001, respectively). The mean SOD, TOS and OSI levels of the TPB and FPB groups were significantly higher than those of the control group (p < 0.001). There was no significant difference between the TPB and FPB groups for any oxidative stress biomarkers.

Conclusion

The maternal serum oxidative stress biomarkers are increased in pregnancies with TPL. However, these are not effective in predicting preterm birth in pregnancies with TPL.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

The authors have not disclosed any funding.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey

    Kübra Hamzaoğlu Canbolat

  2. Department of Obstetrics and Gynecology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Kocamustafapasa, Fatih, 34098, Istanbul, Turkey

    Mahmut Öncül

  3. Department of Perinatalogy, Ümraniye Training and Research Hospital, Istanbul, Turkey

    Ayşegül Özel

  4. Department of Perinatalogy, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey

    Ebru Alıcı Davutoğlu, Didem Kaymak & Rıza Madazlı

  5. Department of Medical Biochemistry, Istinye University Medical Faculty, Istanbul, Turkey

    Huri Bulut

Authors
  1. Kübra Hamzaoğlu Canbolat
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  2. Mahmut Öncül
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  3. Ayşegül Özel
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  4. Ebru Alıcı Davutoğlu
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  5. Didem Kaymak
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  6. Huri Bulut
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  7. Rıza Madazlı
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Contributions

All the authors contributed a lot to this research: K-HC: study design, data collection and writing; MÖ, HB: analysis and writing, AÖ: data collection and writing; E-AD: data collection, analysis and writing; DK: study design, data collection, analysis and writing; RM: study design, data collection, analysis and writing, data interpretation and revision of the draft.

Corresponding author

Correspondence to Kübra Hamzaoğlu Canbolat.

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Hamzaoğlu Canbolat, K., Öncül, M., Özel, A. et al. Oxidative stress and antioxidant status in threatened preterm labor. Arch Gynecol Obstet 309, 1395–1400 (2024). https://doi.org/10.1007/s00404-023-07023-7

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  • DOI: https://doi.org/10.1007/s00404-023-07023-7

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