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Anti–müllerian hormone as a predictor for live birth among women undergoing IVF/ICSI in different age groups: an update of systematic review and meta-analysis

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Abstract

Purpose

To update the evidence of anti–müllerian hormone (AMH) as predictive factors for live birth outcome in women undergoing assisted conception and discover the modulating effect of age.

Methods

PubMed, Embase, Medline, and Web of Science were searched for studies published until June 2021. We included studies that measured serum AMH levels and reported the subsequent live birth outcomes. Random effects models and hierarchical summary receiver operating characteristics (HSROC) models were used. The QUADAS–2 checklist was employed to assess the quality of the included studies.

Results

We included 27 studies (27,029 women) investigating the relationship between AMH and live birth outcome after assisted conception. The diagnostic odds ratios (DOR) from random effects models were ruled out due to high heterogeneity. Our findings suggested that AMH was associated with live birth. The DOR was 2.21 (95% CI 1.89–2.59), and 2.49 (95% CI 1.26–4.91) for studies on women with unspecified ovarian reserve and women with low ovarian reserve, respectively. The DOR of those with advanced ages was 2.50 (95% CI 1.87–2.60). For younger women, the DOR was 1.41 (95% CI 0.99–2.02). HSROCs showed that AMH had no predictive ability towards live birth in women with diminished ovarian reserve or younger age. Exclusion of Chinese cohorts lowered the heterogeneity.

Conclusions

This study revealed that AMH had better prediction for live birth in advanced–age women. AMH may have implicative predictive value for assisted conception counseling of couples of advanced ages.

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  1. Ni-jie Li and Qing-yun Yao contributed equally to this work.

Authors and Affiliations

  1. Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, 430030, Hubei, People’s Republic of China

    Ni-jie Li, Qing-yun Yao, Xiao-qiong Yuan, Yong Huang & Yu-Feng Li

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  1. Ni-jie Li
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Contributions

N.J.L. (M.D., Obstetrics and Gynecology, Reproductive medicine): study design, literature searching, data collection, data analysis, manuscript writing. Q.Y.Y. (M.M., Obstetrics and Gynecology, Reproductive medicine): literature searching, data collection, data analysis, manuscript writing. X.Q.Y. (Ph.D., Obstetrics and Gynecology, Reproductive medicine): methodology reviewing, draft revision. Y.H. (M.D., Obstetrics and Gynecology, Reproductive medicine): data analysis, methodology reviewing. Y.F.L. (M.D., Prof., Obstetrics and Gynecology, Reproductive medicine): study design, draft revision.

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Correspondence to Yu-Feng Li.

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Li, Nj., Yao, Qy., Yuan, Xq. et al. Anti–müllerian hormone as a predictor for live birth among women undergoing IVF/ICSI in different age groups: an update of systematic review and meta-analysis. Arch Gynecol Obstet 308, 43–61 (2023). https://doi.org/10.1007/s00404-022-06683-1

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