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Changes in trends over time for the specific contribution of different risk factors for pre-eclampsia

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The prevalence of risk factors for pre-eclampsia has changed over time; however, little is known regarding how these changes have altered the specific contribution of each risk factor. We aim to identify trends in the contribution of different risk factors throughout different time intervals.

Methods

We compared the prevalence and odds-ratio of different known risk factors for pre-eclampsia occurring in three equal population groups from 1988 to 2014. Data was retrieved from our medical center's perinatal database. A multivariable logistic regression model was employed to identify independent risk factors for pre-eclampsia. We evaluated changes in risk factors and their specific contribution to the occurrence of pre-eclampsia over time and a comparison of the prevalence and odds-ratios of chosen risk factors between the three time periods was performed.

Results

295,946 pregnancies met the inclusion criteria; of those, 16,246 (5.5%) were complicated with pre-eclampsia with the incidence increasing from 8 to 11%. Chronic hypertension, systemic lupus erythematosus, pre-gestational diabetes mellitus, twin pregnancy, advanced maternal age and fertility treatments were found to be the strongest independent risk factors. While rates of twin pregnancies and pre-gestational diabetes mellitus have demonstrated a linear increase, fertility treatments demonstrated a linear decrease. Chronic hypertension and systemic lupus erythematosus resulted in a mixed trend.

Conclusion

In our study, not only did the rates of different risk factors for pre-eclampsia change over the study period, the specific contribution of each risk factor for the occurrence of pre-eclampsia changed as well. Developing a better understanding of these trends might aid in our ability to predict this major complication and to improve maternal and fetal outcomes.

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Acknowledgements

We thank the women which participated in our study.

Funding

We did not receive any funding for this manuscript.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Yohai Shraga, Gali Pariente, Yael Baumfeld, Shayna Miodownik & Adi Y. Weintraub

  2. Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Affiliated with the Hebrew University Medical School of Jerusalem, 12 Bayit street, 91031, Jerusalem, Israel

    Reut Rotem

Authors
  1. Yohai Shraga
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  2. Gali Pariente
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  3. Reut Rotem
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  4. Yael Baumfeld
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  5. Shayna Miodownik
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  6. Adi Y. Weintraub
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Contributions

I declare that I participated in manuscript writing, data management and project development, and that I have seen and approved the final version. I have no following conflicts of interest: YS. I declare that I participated in manuscript writing, data management and project development and that I have seen and approved the final version. I have no following conflicts of interest: GP. I declare that I participated the project development, manuscript editing, and that I have seen and approved the final version. I have no following conflicts of interest: AW. I declare that I participated in protocol development, data analysis and manuscript editing, and that I have seen and approved the final version. I have no following conflicts of interest: RR. I declare that I participated in protocol development, data analysis and manuscript editing, and that I have seen and approved the final version. I have no following conflicts of interest: YB. I declare that I participated in the manuscript editing, and that I have seen and approved the final version. I have no following conflicts of interest: SM.

Corresponding author

Correspondence to Reut Rotem.

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Conflict of interest

We declare that we have no conflict of interest.

Ethical approval

The study was approved by the Institutional Review Board in accordance with the Helsinki declaration (Protocol number SOR- 18- 0104).

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Informed consent was obtained from all individual participants included in the study.

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Shraga, Y., Pariente, G., Rotem, R. et al. Changes in trends over time for the specific contribution of different risk factors for pre-eclampsia. Arch Gynecol Obstet 302, 977–982 (2020). https://doi.org/10.1007/s00404-020-05693-1

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  • DOI: https://doi.org/10.1007/s00404-020-05693-1

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