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The effects of tocolysis on neonatal septic death in women with PPROM: a retrospective cohort study

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

In women with preterm premature rupture of membranes (PPROM), particularly those with suspected chorioamnionitis, the benefit of tocolysis on neonatal outcome remains unclear. Our purpose was to evaluate the effect of tocolysis on neonatal septic death in women with PPROM with and without chorioamnionitis.

Methods

A retrospective cohort study was used to address our study objective. We created a cohort consisting of all live births between 24 and 32 weeks’ gestation that were registered in the Linked Birth and Infant Death data files (2009–2013) from the United States. Multivariate logistic regression was used to evaluate the effect of tocolysis on neonatal septic death at 7 and 28 days in births with and without chorioamnionitis.

Results

Of the 46,968 births that met our inclusion criteria, tocolysis was administered to 6264 (13.3%). Tocolysis was more commonly prescribed to Caucasians, smokers, in multiple birth pregnancies, and to women with a history of preterm births. Tocolysis was not significantly associated with neonatal septic death at 7 days (OR 0.66, 95% CI 0.39–1.13) or at 28 days (OR 0.85, 95% CI 0.60–1.19). This was consistent in pregnancies with and without chorioamnionitis. Furthermore, tocolysis was associated with a reduced risk of neonatal septic death at 7 days when administered between 24 and 27 weeks’ gestation (OR 0.44, 95% CI 0.22–0.88).

Conclusions

In the setting of PPROM, tocolysis does not appear to increase the risk of neonatal septic death at 7 and 28 days. Therefore, consideration should be given to its administration if clinically indicated.

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Funding

No funding was received for this study. AC was a recipient of a McGill University Robert Courey Research Bursary. This was personal funding.

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Authors and Affiliations

  1. Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, QC, Canada

    Ariel Chackowicz, Nicholas Czuzoj-Shulman & Haim Arie Abenhaim

  2. Department of Obstetrics and Gynecology and Epidemiology, Jewish General Hospital, McGill University, 5790 Cote-des-Neiges, H412, Montreal, QC, H3T 1E2, Canada

    Haim Arie Abenhaim

Authors
  1. Ariel Chackowicz
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  2. Nicholas Czuzoj-Shulman
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  3. Haim Arie Abenhaim
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Contributions

AC: Contributed to study design; interpretation of data; drafting of manuscript. NC-S: Data management; data analysis; revision of manuscript. HAA: Conception and design; acquisition of data; supervision; interpretation of data; critical revision of manuscript for important intellectual content.

Corresponding author

Correspondence to Haim Arie Abenhaim.

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Conflict of interest

The authors report no conflict of interest. We had full control of all primary data and we agree to allow the Journal to review these data, if requested.

Ethical approval

This study used exclusively publicly available data; hence, according to the Tri-Council Policy statement (2010), institutional review board approval was not required.

Informed consent

This study used exclusively publicly available data; hence, we did not personally obtain informed consent from study subjects. This would be the responsibility of the Agency for Healthcare Research and Quality (AHRQ), who sponsors the National Inpatient Sample.

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Chackowicz, A., Czuzoj-Shulman, N. & Abenhaim, H.A. The effects of tocolysis on neonatal septic death in women with PPROM: a retrospective cohort study. Arch Gynecol Obstet 298, 897–902 (2018). https://doi.org/10.1007/s00404-018-4871-9

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  • DOI: https://doi.org/10.1007/s00404-018-4871-9

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