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Dominant factors affecting reproductive outcomes of fertility-desiring young women with intrauterine adhesions

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To identify the dominant factors affecting reproductive outcomes of fertility-desiring young women with intrauterine adhesions (IUA) after hysteroscopic adhesiolysis.

Methods

This prospective observational study included 104 cases of women with IUA. Logistic regression analysis was applied to analyze the value of the location and extent of adhesions, the number of previous uterine cavity surgery, menstrual patterns, and second look hysteroscopy time.

Results

In the total 104 patients with IUA, 91 patients (87.5%) had a history of at least one previous uterine cavity surgery. Hypomenorrhoea and amenorrhoea were two most common presenting menstrual abnormalities occurring in 59 (56.7%) and 28 (26.9%) cases, respectively. The clinical pregnancy rate was 60.6% (63/104) and the live birth rate was 39.4% (41/104). Pregnancy rate was higher in patients having mild IUA (81.5%) as compared to moderate (61.3%) or severe type (20.0%) (p < 0.001). The bivariate and binary logistic regression analysis revealed that the location and extent of adhesions were the independent parameters related to the reproductive outcome after hysteroscopic adhesiolysis for fertility-desiring women with IUA (p = 0.011 and p = 0.003, respectively), but not the number of previous uterine cavity surgery, menstrual patterns, and second look hysteroscopy time (p = 0.232, p = 0.239 and p = 0.120, respectively).

Conclusion

The extent and location of IUA are the dominant factors affecting reproductive outcomes, which are possibly regarded as a potential predictor evaluating prognosis of IUA after hysteroscopic adhesiolysis.

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Abbreviations

IUA:

Intrauterine adhesions

IUD:

Intrauterine device

3 W:

3 weeks

1 M:

1 month

3M:

3 months

D&C:

Dilatation & Curettage

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Acknowledgements

This work was supported by a grant from the National Natural Science Foundation of China (Youth Grant, No. 31201118). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author contributions

Conceived and designed the experiments: JYZ XX. Collected the data: JYZ QC. Analyzed the data: JYZ ZD. Contributed analysis tools: DGC XHL. Wrote the paper: JYZ QC.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 of Xiwu Road, Xi’an, People’s Republic of China

    Jinyan Zhao, Qing Chen, Dongge Cai, Zhao Duan, Xianghong Li & Xiang Xue

Authors
  1. Jinyan Zhao
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  2. Qing Chen
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  3. Dongge Cai
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  4. Zhao Duan
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  5. Xianghong Li
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  6. Xiang Xue
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Corresponding author

Correspondence to Xiang Xue.

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We declare that we have no conflict of interest.

Ethical statement

Medical Ethics Commission approval was obtained before the study. All participants provided their informed consent before their involvement in this study.

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Zhao, J., Chen, Q., Cai, D. et al. Dominant factors affecting reproductive outcomes of fertility-desiring young women with intrauterine adhesions. Arch Gynecol Obstet 295, 923–927 (2017). https://doi.org/10.1007/s00404-017-4314-z

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  • DOI: https://doi.org/10.1007/s00404-017-4314-z

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