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Changes in endometrial receptivity in women with Asherman’s syndrome undergoing hysteroscopic adhesiolysis

  • Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

To determine whether there is any improvement in the endometrial receptivity in infertile women with Asherman’s syndrome undergoing hysteroscopic adhesiolysis.

Materials and methods

This was a prospective observational clinical analysis of 40 infertile patients who underwent hysteroscopic adhesiolysis for Asherman’s syndrome in a tertiary level hospital. Endometrial thickness and blood flow impedance of the uterine spiral artery by transvaginal color pulsed Doppler ultrasound was measured post-menstrual on day 2/3 and post-menstrual on day 21 pre- and post-hysteroscopic adhesiolysis or at a randomly chosen time in patients with amenorrhea.

Results

The age of the patients was 18–36 years (mean 29.2 years). The mean duration of infertility was 6.9 years. There were 27 (67.5 %) women with primary infertility and 13 (32.5 %) had secondary infertility. 22 (55 %) women had had genital tuberculosis in the past. A significant improvement in the endometrial thickness was observed on day 2 (p < 0.0001) and day 21 (p < 0.0001) 3 months post-adhesiolysis. The spiral artery RI was statistically significant (p < 0.04) on day 2 pre-adhesiolysis compared to post-adhesiolysis.

Conclusions

A significant improvement in the endometrial thickness was observed post-adhesiolysis. A high blood flow impedance of spiral artery perhaps impairs growth of the endometrium making it unsuitable for successful implantation.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, 3076, 3rd Floor, Teaching Block, New Delhi, 110 029, India

    Neena Malhotra, Anupama Bahadur & Suneeta Mittal

  2. Department of Statistics, All India Institute of Medical Sciences, New Delhi, India

    Mani Kalaivani

Authors
  1. Neena Malhotra
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  2. Anupama Bahadur
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  3. Mani Kalaivani
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  4. Suneeta Mittal
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Correspondence to Anupama Bahadur.

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Malhotra, N., Bahadur, A., Kalaivani, M. et al. Changes in endometrial receptivity in women with Asherman’s syndrome undergoing hysteroscopic adhesiolysis. Arch Gynecol Obstet 286, 525–530 (2012). https://doi.org/10.1007/s00404-012-2336-0

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  • DOI: https://doi.org/10.1007/s00404-012-2336-0

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