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Association between zinc level and the risk of preeclampsia: a meta-analysis

Archives of Gynecology and Obstetrics volume 293, pages 377–382 (2016)Cite this article

Abstract

Background

Epidemiological studies evaluating the association between zinc level and the risk of preeclampsia have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence for them.

Methods

Pertinent studies were identified by a search in PubMed and Web of Knowledge up to April 2015. Standardized mean difference (SMD) was performed to combine the results. Random-effect model was used. Publication bias was estimated using Egger’s regression asymmetry test.

Results

Thirteen articles (11 case–control studies and 2 cross-sectional studies) involving 445 preeclampsia cases and 568 healthy controls were included in this meta-analysis. Our pooled results suggested that preeclampsia patients had a lower zinc level as compared with healthy, pregnant controls (summary SMD = −0.61, 95 % CI = −0.74, −0.48, I 2 = 88.5 %). The association was also significant in Asia (SMD = −0.73, 95 % CI = −0.88, −0.58), but not in Europe. No publication biases were found.

Conclusions

Our analysis indicated that zinc level in preeclampsia patients was significantly lower than that of healthy, pregnant women, especially among the Asian population.

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Authors and Affiliations

  1. Department of Prenatal Diagnosis Center, Nantong Maternity and Child Health Hospital, Nantong, Jiangsu, 226006, People’s Republic of China

    Qingwen Zhu, Lingli Zhang, Xiaobo Chen, Jun Zhou & Jiangyue Liu

  2. President’s Office, Nantong Maternity and Child Health Hospital, No. 399, Century Avenue, Nantong, Jiangsu, 226006, People’s Republic of China

    Jianhua Chen

Authors
  1. Qingwen Zhu
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  2. Lingli Zhang
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  3. Xiaobo Chen
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  4. Jun Zhou
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  5. Jiangyue Liu
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  6. Jianhua Chen
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Correspondence to Jianhua Chen.

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Zhu, Q., Zhang, L., Chen, X. et al. Association between zinc level and the risk of preeclampsia: a meta-analysis. Arch Gynecol Obstet 293, 377–382 (2016). https://doi.org/10.1007/s00404-015-3883-y

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  • DOI: https://doi.org/10.1007/s00404-015-3883-y

Keywords

  • Zinc level
  • Preeclampsia
  • Meta-analysis